Staff Scientist, Genentech
Pathology
Andrey S. Shaw
Andrey S. Shaw works in the field of Pathology. He researched medicine at Columbia University College of Physicians & Surgeons. Columbia University College of Physicians & Surgeons is one of the top medical schools in the US. Columbia University College of Physicians & Surgeons is ranked 8 in research and 52 in primary care medicine He has 1 awards "Investigator". Andrey Shaw is a published doctor as well. He has 101 publications published. The latest was: A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
Publications
- Real-Time Analysis of Calcium Signals during the Early Phase of T Cell Activation Using a Genetically Encoded Calcium Biosensor.
- Kinase regulation by hydrophobic spine assembly in cancer.
- Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease.
- Neonatal Fc Receptor Promotes Immune Complex-Mediated Glomerular Disease.
- Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL.
- CD2-Associated Protein Regulates Plasmacytoid Dendritic Cell Migration, but Is Dispensable for Their Development and Cytokine Production.
- Albuminuria associated with CD2AP knockout mice is primarily due to dysfunction of the renal degradation pathway processing of filtered albumin.
- Pseudokinases from a structural perspective.
- Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers.
- Imaging murine NALT following intranasal immunization with flagellin-modified circumsporozoite protein malaria vaccines.
- Heterogeneous distribution of natural zinc isotopes in mice.
- Kinase suppressor of ras 1 is not required for the generation of regulatory and memory T cells.
- CD2AP links cortactin and capping protein at the cell periphery to facilitate formation of lamellipodia.
- RAE1? Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition.
- CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival.
- Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis.
- Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF.
- Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR- but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity st...
- Understanding the structure and function of the immunological synapse.
- Immunology. CAR'ing for the skin.
- The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.
- Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice.
- KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.
- TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes.
- The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization.
- Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin.
- New roles revealed for T cells and DCs in glomerulonephritis.
- KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs.
- The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse.
- IL-12 enhances CTL synapse formation and induces self-reactivity.
- The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage.
- Regulated movement of CD4 in and out of the immunological synapse.
- CD45 down-regulates Lck-mediated CD44 signaling and modulates actin rearrangement in T cells.
- The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.
- Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
- How T cells 'find' the right dendritic cell.
- Podocytes use FcRn to clear IgG from the glomerular basement membrane.
- Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse.
- Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism.
- Scaffold proteins confer diverse regulatory properties to protein kinase cascades.
- The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.
- The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis.
- Lipid rafts: now you see them, now you don't.
- Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulat...
- Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics.
- Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier.
- Identification of a novel inhibitory actin-capping protein binding motif in CD2-associated protein.
- Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.
- The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence.
- Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation.
- Live Cell Imaging of ERK and MEK: simple binding equilibrium explains the regulated nucleocytoplasmic distribution of ERK.
- T-cell activation and immunologic synapse.
- A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis.
- Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155).
- The immunological synapse balances T cell receptor signaling and degradation.
- In silico models for cellular and molecular immunology: successes, promises and challenges.
- Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling.
- CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility.
- Slick signaling.
- Inhibitory smads and tgf-Beta signaling in glomerular cells.
- Cutting edge: quantitative imaging of raft accumulation in the immunological synapse.
- Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation.
- Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo.
- Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation.
- Regulation of Lck activity by CD4 and CD28 in the immunological synapse.
- T cell receptor signaling precedes immunological synapse formation.
- Role of NKG2D in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance.
- Nanoscale protein architecture of the kidney glomerular basement membrane.
- Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection.
- Scaffold proteins and immune-cell signalling.
- Glomerular expression of transforming growth factor-beta (TGF-beta) isoforms in mice lacking CD2-associated protein.
- MAPK p38 alpha is dispensable for lymphocyte development and proliferation.
- CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency.
- Association of CD2AP with dynamic actin on vesicles in podocytes.
- Getting downstream without a Raft.
- The c-SMAC: sorting it all out (or in).
- Scaffolds, adaptors and linkers of TCR signaling: theory and practice.
- The immunological synapse and CD28-CD80 interactions.
- CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.
- CD28 and the tyrosine kinase lck stimulate mitogen-activated protein kinase activity in T cells via inhibition of the small G protein Rap1.
- Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins.
- Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy.
- 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity.
- A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.
- Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.
- Kissing cousins: immunological and neurological synapses.
- CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.
- Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.
- The immunological synapse.
- Congenital nephrotic syndrome in mice lacking CD2-associated protein.
- Environmental control of immunological synapse formation and duration.
- Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL.
- Coordinate regulation of T cell activation by CD2 and CD28.
- T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.
- CD2AP/CIN85 balance determines receptor tyrosine kinase signaling response in podocytes.
- Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase.
- Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.
- CD2-associated protein and the kidney.
- Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation.
- Making the T cell receptor go the distance: a topological view of T cell activation.
Schools
Columbia University College of Physicians And Surgeons
Doctors Specialties
- General Surgery
- Pathology
Accepted Insurances
Awards
- Investigator
Education
-
Yale University School of Medicine -
Yale-New Haven Hospital -
Columbia University College of Physicians & Surgeons
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