Professor, Microbiology, University of Alabama School of Medicine
Internal Medicine
David D. Chaplin
David Chaplin works in the field of Internal Medicine. He graduated from Washington University School of Medicine in St. Louis. He received 2 awards: "Elected Member" and "Investigator Alumnus". David D. Chaplin is a published physician as well. He has 101 publications published. The latest was: Cytokine regulation of secondary lymphoid organ development. He accepts Medicare payments and is registered with Medicare.gov.
Publications
- IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production.
- Subsets of airway myeloid-derived regulatory cells distinguish mild asthma from chronic obstructive pulmonary disease.
- IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis.
- A myeloid cell-binding adenovirus efficiently targets gene transfer to the lung and escapes liver tropism.
- Regulatory role of antigen-induced interleukin-10, produced by CD4(+) T cells, in airway neutrophilia in a murine model for asthma.
- Neutrophils produce IL-17A in a Dectin-1 and IL-23 dependent manner during invasive fungal infection.
- AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils.
- Elevated levels of NO are localized to distal airways in asthma.
- Inhibition of Neutrophil Apoptosis by PAI-1.
- Important role of neutrophils in the late asthmatic response in mice.
- Inhibition of the catalytic function of activation-induced cytidine deaminase (AICDA) promotes apoptosis of germinal center B cells.
- Follicular dendritic cell makes environmental sense.
- Immunology. Tumor immune evasion.
- Overview of the immune response.
- Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity.
- Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae.
- The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function.
- Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells.
- Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology.
- Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.
- Antigen and lipopolysaccharide play synergistic roles in the effector phase of airway inflammation in mice.
- 1. Overview of the human immune response.
- Taking control of follicular dendritic cells.
- Localization of T and B lymphocytes to the white pulp of the spleen is independent of L-, E-, and P-selectin.
- Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node.
- Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function.
- 1. Overview of the immune response.
- Antigen-nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection-induced allergic asthma.
- IgE cross-linking or lipopolysaccharide treatment induces recruitment of Th2 cells to the lung in the absence of specific antigen.
- Nonhematopoietic expression of Janus kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation.
- T helper type 1 cells in asthma: friend or foe?
- Cell cooperation in development of eosinophil-predominant inflammation in airways.
- Regulation of spleen white pulp structure and function by lymphotoxin.
- Molecular Dissection of the Murine IL-1beta Promoter.
- Combination chemotherapy including combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model.
- Multiple mechanisms of action of the benzamides and nicotinamides as sensitizers of radiotherapy: opportunities for drug design.
- Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene.
- Molecular analysis of the murine C4b-binding protein gene. Chromosome assignment and partial gene organization.
- Newly discovered anti-inflammatory properties of the benzamides and nicotinamides.
- Interleukin-1 alpha and beta genes: linkage on chromosome 2 in the mouse.
- Inhibition of lectin-induced lymphocyte activation by diamide and other sulfhydryl reagents.
- The B144-H-2Db interval and the location of a mouse homologue of the human D6S81E locus.
- Nucleotide sequence analysis of murine 21-hydroxylase genes: mutations affecting gene expression.
- Eukaryotic chromosome transfer: linkage of the murine major histocompatibility complex to an inserted dominant selectable marker.
- Molecular map of the murine S region.
- Human complement C3b/C4b receptor (CR1) mRNA polymorphism that correlates with the CR1 allelic molecular weight polymorphism.
- Expression of murine 21-hydroxylase in mouse adrenal glands and in transfected Y1 adrenocortical tumor cells.
- Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man.
- cDNA selection: efficient PCR approach for the selection of cDNAs encoded in large chromosomal DNA fragments.
- Cloning and physical mapping of the HLA class I region spanning the HLA-E-to-HLA-F interval by using yeast artificial chromosomes.
- Targets in cytokine activation.
- Protein phosphorylation in human peripheral blood lymphocytes. Subcellular distribution and partial characterization of adenosine 3'':5''-cyclic monophosphate-dependen...
- [A polymorphic markers for the p75 tumor necrosis factor receptor gene: use for analyzing disease linkage].
- Regulation of the human chorionic gonadotrophin beta subunit genes.
- Early activation events in lectin-stimulated human lymphocytes: evidence that wheat germ agglutinin and mitogenic lectins cause similar early changes in lymphocyte met...
- Protein phosphorylation in human peripheral blood lymphocytes: mitogen-induced increases in protein phosphorylation in intact lymphocytes.
- IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
- Interleukin-1beta promotes repair of the CNS.
- Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice.
- Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.
- Chromosomal localization of five murine HSP70 gene family members: Hsp70-1, Hsp70-2, Hsp70-3, Hsc70t, and Grp78.
- Fluorescent automated sequencing of supercoiled high molecular weight double-stranded DNA.
- Molecular biology and genetics of interleukin-1.
- Compartmentalization of mammalian proteins produced in Escherichia coli.
- Overview of strategies for screening YAC libraries and analyzing YAC clones.
- Analysis of isolated YAC clones.
- Construction of a genomic DNA ''feature map'' by sequencing from nested deletions: application to the HLA class I region.
- Feature mapping of the HLA class I region: localization of the POU5F1 and TCF19 genes.
- A novel Creb family gene telomeric of HLA-DRA in the HLA complex.
- The major histocompatibility complex and autoimmunity.
- Molecular linkage of the HLA-DR, HLA-DQ, and HLA-DO genes in yeast artificial chromosomes.
- A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.
- Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. II. Identification of (tissue) macrophages as the IL-1 producing cells and the effect ...
- Interleukin-1 (IL-1) production in a mouse tissue chamber model of inflammation. I. Development and initial characterisation of the model.
- Regulation of interleukin 1 gene expression by adherence and lipopolysaccharide.
- An NFIL-6 sequence near the transcriptional initiation site is necessary for the lipopolysaccharide induction of murine interleukin-1 beta.
- Isolation and characterization of yeast artificial chromosome clones linking the HLA-B and HLA-C loci.
- Identification of a promoter region in the CG beta gene cluster.
- Genomic organization of mouse Fc gamma receptor genes.
- Regulation of IL-1 gene expression: differential responsiveness of murine macrophage lines.
- Genetic variability at the human tumor necrosis factor loci.
- A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1 beta gene.
- Cytokine regulation of secondary lymphoid organ development.
- Development and maturation of secondary lymphoid tissues.
- Macrophage apoptosis in the absence of active interleukin-1 beta-converting enzyme.
- Anaphylaxis to intravenous furosemide.
- Deletion of C4A genes in patients with systemic lupus erythematosus.
- HLA-linked skin disease: classical HLA genes or novel genes within HLA?
- Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors.
- Genes in one megabase of the HLA class I region.
- Molecular cloning of the murine IL-1 beta converting enzyme cDNA.
- Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.
- Germline organization of the murine T cell receptor beta-chain genes.
- Simultaneous transfer of four functional genes from the HLA class II region into mammalian cells by fusion with yeast spheroplasts carrying an artificial chromosome.
- Release of IL-1 from mononuclear phagocytes.
- Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation.
- Confocal fluorescent intravital microscopy of the murine spleen.
- Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo.
- Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers.
- Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone.
Schools
Washington Center School of Medicine
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
- Investigator Alumnus
Education
-
Washington University School of Medicine in St. Louis
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