Emeritus Faculty at Univ. California, San Diego
Gastroenterology
Dr. Alan F. Hofmann, MD
|
|
Give Review
Alan Hofmann works in the field of Gastroenterology. He studied medicine at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical college. Johns Hopkins University School of Medicine is ranked 3 in research and 29 in primary care medicine He received 3 awards: "Fellow (AGAF)", "Whos Who in Medicine and Healthcare" and "Elected Member". Dr. Alan F. Hofmann is a published doctor as well. He has 68 publications published. The latest was: Bile Acid Chemistry, Biology, and Therapeutics During the Last 80 Years: Historical Aspects.
Publications
- Bile Acid Chemistry, Biology, and Therapeutics During the Last 80 Years: Historical Aspects.
- Development of a simple and accurate HPLC method for measurement of fecal bile acids: validation by GC-MS and LC-MS and application in healthy and cirrhotic patients.
- N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): a novel bile acid profile in Perciform fish.
- Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids.
- The bile acid TGR5 membrane receptor: From basic research to clinical application.
- Ursodeoxycholic acid attenuates colonic epithelial secretory function.
- Genetic Defects In Bile Acid Conjugation Cause Fat-Soluble Vitamin Deficiency.
- A Novel Varanic Acid Epimer - (24R, 25S)-3α,7α,12α,24-Tetrahydroxy-5β-cholestan-27-oic Acid - is a Major Biliary Bile Acid in Two Varanid Lizards and the Gila Mons...
- Identification of S-acyl glutathione conjugates of bile acids in human bile by means of LC/ESI-MS.
- Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-...
- Bile acid sequestrants improve glycemic control in type 2 diabetes: A proposed mechanism implicating glucagon-like peptide 1 release.
- Chemical synthesis of the (25R)- and (25S)-epimers of 3α,7α,12α-trihydroxy-5α-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates.
- Characterization of non-enzymatic acylation of amino or thiol groups of bionucleophiles by the acyl-adenylate or acyl-CoA thioester of cholic acid.
- Synthesis of the 3-sulfates of N-acetylcysteine conjugated bile acids (BA-NACs) and their transient formation from BA-NACs and subsequent hydrolysis by a rat liver cyt...
- Identification of bile acid S-acyl glutathione conjugates in rat bile by liquid chromatography/electrospray ionization-linear ion trap mass spectrometry.
- Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver.
- Hepatobiliary disposition of 3alpha,6alpha,7alpha,12alpha-tetrahydroxy-cholanoyl taurine: a substrate for multiple canalicular transporters.
- COMPLEX EVOLUTION OF BILE SALTS IN BIRDS.
- Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway.
- Bile salts of vertebrates: structural variation and possible evolutionary significance.
- Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release.
- Chemical synthesis of bile acid acyl-adenylates and formation by a rat liver microsomal fraction.
- Chemical synthesis of 3beta-sulfooxy-7beta-hydroxy-24-nor-5-cholenoic acid: an internal standard for mass spectrometric analysis of the abnormal delta5-bile acids occu...
- Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice.
- Bile acids: trying to understand their chemistry and biology with the hope of helping patients.
- A new, major C27 biliary bile acid in the red-winged tinamou (Rhynchotus rufescens):25R-1beta, 3alpha,7alpha-trihydroxy-5beta-cholestan-27-oic acid.
- Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea.
- A facile synthesis of C-24 and C-25 oxysterols by in situ generated ethyl(trifluoromethyl)dioxirane.
- In memoriam: Dr. Herbert Falk (1924-2008).
- The enterohepatic circulation of bile acids in mammals: form and functions.
- Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients.
- Evolution of the bile salt nuclear receptor FXR in vertebrates.
- Cytosol-nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes.
- Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.
- Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15alpha-hydroxylithocholic acid.
- Human cecal bile acids: concentration and spectrum.
- Enhancement of dietary protein digestion by conjugated bile acids.
- Why bile acid glucuronidation is a minor pathway for conjugation of endogenous bile acids in man.
- Regioselective oxyfunctionalization of unactivated carbons in steroids by a model of cytochrome P-450: osmiumporphyrin complex/tert-butyl hydroperoxide system.
- Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships.
- Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by choles...
- Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit.
- Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid.
- Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.
- Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor.
- Nasobiliary drainage for cholestatic pruritus.
- Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione.
- How bile acids confer gut mucosal protection against bacteria.
- Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep.
- 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.
- Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3beta,7beta-dihydroxy-5-cholen-24-oic acid, and related compounds: unusual, major...
- Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptid...
- Novel biotransformation and physiological properties of norursodeoxycholic acid in humans.
- Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis.
- A phylogenetic survey of biliary lipids in vertebrates.
- Helicobacter and cholesterol gallstones: do findings in the mouse apply to man?
- Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump.
- Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity.
- Douglas B. McGill, 1929-2004.
- Chemical synthesis of (22E)-3 alpha,6 beta,7 beta-trihydroxy-5 beta-chol-22-en-24-oic acid and its taurine and glycine conjugates: a major bile acid in the rat.
- Fondaparinux for symptomatic pulmonary embolism.
- Accurate enzymatic measurement of fecal bile acids in patients with malabsorption.
- Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats.
- Conjugated bile acid replacement therapy reduces urinary oxalate excretion in short bowel syndrome.
- Human CYP7A1 deficiency: progress and enigmas.
- Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2.
- Bile Acids: The Good, the Bad, and the Ugly.
Schools
Johns Hopkins University School of Medicine
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Fellow (AGAF)
- Whos Who in Medicine and Healthcare
- Elected Member
Education
-
New York Presbyterian Hospital - Columbia Campus -
Johns Hopkins University School of Medicine
Helpful Reviews
Similar Doctors
|
|
Dr. Douglas A. Politoske, MD
 This Doctor is OpenDoctor Recommended.
|
|
Dr. Heather M. Patton, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Meng M. Hua, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Brett J. Partridge, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Mario M. Chojkier, MD
This Doctor is OpenDoctor Recommended.
 This doctor has more publications
|
|
|
Dr. Pradipta Ghosh, MD |
|
|
Dr. Samuel B. Ho, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Samir Gupta, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Mamie H. Dong, MD |