Professor of Medicine, University MD School of Medicine
Endocrinology
Dr. Alan R. Shuldiner, MD
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Doctor Alan R. Shuldiner, MD works in the field of Endocrinology. He studied medicine at Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School has a rank of 1 in research and a 12 in primary care He over the years received 2 awards: "Super Doctor" and "Whos Who in Medicine and Healthcare". Alan Shuldiner is also a published physician. He has 102 paper published. The most recent paper is: Assignment of functional relevance to genes at type 2 diabetes-associated loci through investigation of -cell mass deficits. Alan Shuldiner is registered with Medicare.
Publications
- Assignment of functional relevance to genes at type 2 Diabetes-associated loci through investigation of β-cell mass deficits.
- Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
- Educational Innovations in Clinical Pharmacogenomics.
- Gene Expression Differences Between Offspring of Long-Lived Individuals and Controls in Candidate Longevity Regions: Evidence for PAPSS2 as a Longevity Gene.
- Heritability of complex white matter diffusion traits assessed in a population isolate.
- The common genetic influence over processing speed and white matter microstructure: Evidence from the Old Order Amish and Human Connectome Projects.
- Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogr...
- Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.
- Genetic studies of body mass index yield new insights for obesity biology.
- New genetic loci link adipose and insulin biology to body fat distribution.
- Effect of zinc supplementation on insulin secretion: interaction between zinc and SLC30A8 genoType in Old Order Amish.
- Identification of a variant in KDR associated With serum VEGFR2 and pharmacodynamics of pazopanib.
- ChronoType and seasonality: Morningness is associated with lower seasonal mood and behavior changes in the Old Order Amish.
- Calcified Granulomatous Disease: Occupational Associations and Lack of Familial Aggregation.
- Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
- Null mutation in hormone-sensitive lipase gene and risk of type 2 Diabetes.
- Effectiveness of clopidogrel dose escalation to normalize active metabolite exposure and antiplatelet effects in CYP2C19 poor metabolizers.
- Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response.
- Familial Aggregation of Tobacco Use Behaviors in Amish Men.
- The INFLUENCE of rare Genetic variation in SLC30A8 on Diabetes incidence and beta-cell function.
- Thrombin-induced platelet-fibrin clot strength: Relation to high on-clopidogrel platelet reactivity, genoType, and post-percutaneous coronary intervention outcomes.
- Common variants associated With plasma triglycerides and risk for coronary artery disease.
- Discovery and refinement of loci associated With lipid levels.
- Decreased Bone Mineral Density in Subjects Carrying Familial Defective Apolipoprotein B-100.
- Stroke Genetics Network (SiGN) Study: Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke SubTypes.
- Common Variants in Mendelian Kidney Disease Genes and Their Association With Renal Function.
- The CYP2C19*17 variant is not independently associated With clopidogrel response.
- Candidate Gene Association Study of Coronary Artery Calcification in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort).
- Pharmacogenomics of anti-platelet and anti-coagulation therapy.
- Purine Pathway Implicated in Mechanism of Resistance to Aspirin Therapy: Pharmacometabolomics-Informed Pharmacogenomics.
- Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 GenoType and Clopidogrel Therapy: 2013 Update.
- Seasonality of mood and behavior in the Old Order Amish.
- Pharmacogenomics of anti-platelet therapy: how much evidence is enough for clinical implementation?
- Genetic Variation at NCAN Locus Is Associated With Inflammation and Fibrosis in Non-Alcoholic Fatty Liver Disease in Morbid Obesity.
- The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Overcoming Challenges of Real-World Implementation.
- Loci influencing blood pressure identified using a cardiovascular gene-centric array.
- Genome-wide association analyses identify 18 new loci associated With serum urate concentrations.
- Genetic Variation in PEAR1 is Associated With Platelet Aggregation and Cardiovascular Outcomes.
- Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated om...
- Living the good life? Mortality and hospital utilization patterns in the Old Order Amish.
- Implementing genomic medicine in the clinic: the future is here.
- The ABCG8 G574R Variant, Serum Plant Sterol Levels, and Cardiovascular Disease Risk in the Old Order Amish.
- The functional G143E variant of carboxylesterase 1 is associated With increased clopidogrel active metabolite levels and greater clopidogrel response.
- Comparison of BMI and Physical Activity Between Old Order Amish Children and Non-Amish Children.
- Analysis of the gut microbiota in the old order amish and its relation to the metabolic syndrome.
- Serum alanine aminotransferase is correlated With hematocrit in healthy human subjects.
- Association between bilirubin and cardiovascular disease risk factors: using Mendelian randomization to assess causal inference.
- Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies.
- GenoType-based changes in serum uric acid affect blood pressure.
- Heritability of serum sodium concentration: evidence for sex- and ethnic-specific effects.
- Determinants of Blood Pressure Response to Low-Salt Intake in a Healthy Adult Population.
- A functional haploType in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density.
- PharmGKB summary: very important pharmacogene information for cytochrome P450, family 2, subfamily C, polypeptide 19.
- Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genoType 1.
- Genetic variation near IRS1 associates With reduced adiposity and an impaired metabolic profile.
- Carrying one or two reduced-function CYP2C19 alleles is associated With an increased risk of major adverse cardiovascular events in people undergoing percutaneous coro...
- The relation between CYP2C19 genoType and phenoType in stented patients on maintenance dual antiplatelet therapy.
- Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
- Meta-analysis identifies 13 new loci associated With waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
- Persistent Staphylococcus aureus colonization is not a strongly heritable trait in Amish families.
- Habitual sleep/wake patterns in the old order amish: heritability and association With non-genetic factors.
- Association of the vitamin D metabolism gene CYP24A1 With coronary artery calcification.
- Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.
- Evaluation of A2BP1 as an obesity gene.
- Platelet aggregation pathway.
- Letter by Gurbel et al regarding article, "Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated ...
- Association of single nucleotide polymorphisms on chromosome 9p21.3 With platelet reactivity: a potential mechanism for increased vascular disease.
- Responding to the clopidogrel warning by the US food and drug administration: real life is complicated.
- Functional variants in MBL2 are associated with type 2 Diabetes and pre-Diabetes traits in Pima Indians and the old order Amish.
- A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated With bone mineral density and influences gene expression in vitro.
- Genotyping: one piece of the puzzle to personalize antiplatelet therapy.
- Genetic effects on postprandial variations of inflammatory markers in healthy individuals.
- The CFTR Met 470 allele is associated With lower birth rates in fertile men from a population isolate.
- Genetic loci influencing kidney function and chronic kidney disease.
- New loci associated With kidney function and chronic kidney disease.
- Variable bone fragility associated With an Amish COL1A2 variant and a knock-in mouse model.
- Extent and distribution of linkage disequilibrium in the Old Order Amish.
- A common variant in the telomerase RNA component is associated With short telomere length.
- The worry about clopidogrel "nonresponsiveness": identification and treatment in the post-percutaneous coronary intervention patient.
- Association of cytochrome P450 2C19 genoType with the antiplatelet effect and clinical efficacy of clopidogrel therapy.
- Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and PhenoType Intervention Heart Study).
- Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated With serum MMP-1 levels.
- Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
- NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
- COL4A1 is associated With arterial stiffness by genome-wide association scan.
- Serum 25-hydroxyvitamin d levels are not associated With subclinical vascular disease or C-reactive protein in the old order amish.
- From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.
- A null mutation in human APOC3 confers a favorable plasma Lipid profile and apparent cardioprotection.
- Obesity genes and gene-environment-behavior interactions: recommendations for a way forward.
- Mammographic breast density--evidence for genetic correlations With established breast cancer risk factors.
- The association of podocin R229Q polymorphism With increased albuminuria or reduced estimated GFR in a large population-based sample of US adults.
- The association of coronary artery calcification and carotid artery intima-media thickness With distinct, traditional coronary artery disease risk factors in asymptoma...
- TCF7L2 variants associate With CKD progression and renal function in population-based cohorts.
- Physical activity and the association of common FTO gene variants With body mass index and obesity.
- Association of a common nonsynonymous variant in GLUT9 With serum uric acid levels in old order amish.
- Expression, purification, and initial characterization of human alanine aminotransferase (ALT) isoenzyme 1 and 2 in High-five insect cells.
- Variations in the G6PC2/ABCB11 genomic region are associated With fasting glucose levels.
- Phosphodiesterase 8B gene variants are associated With serum TSH levels and thyroid function.
- Adiponectin levels and genoType: a potential regulator of life span in humans.
- The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and PhenoType Intervention (HAPI) Heart Study.
- Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.
Schools
Harvard Medical School
Colum Presby Hospital
National Institute Health
Conditions Treated
- Diabetes Mellitus, Secondary
- Diabetes Type 1
- Diabetes Type 2
- Diabetes With Renal Manifestations
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Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Super Doctor
- Whos Who in Medicine and Healthcare
Education
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National Institutes of Health Clinical Center -
New York Presbyterian Hospital - Columbia Campus -
Harvard Medical School
Hospital
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University of Maryland Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1851333884 |
| Last Name Of The Provider | SHULDINER |
| First Name Of The Provider | ALAN |
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