Professor of Surgery and Obstetrics University of Pennsylvania, School of Medicine, CHOP
General Surgery
Dr. Alan W. Flake, MD
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Alan Flake is an expert in the field of General Surgery. He attended University of Arkansas for Medical Sciences College of Medicine. University of Arkansas for Medical Sciences College of Medicine has a rank of 83 in research and a 35 in primary care He received 5 awards: "Philadelphia Magazine", "America's Top Doctors", "Fellow (FAAP)", "Super Doctor" and "Fellow (FACS)". Alan Flake is a published doctor and has 101 publications published. The lastest was: 'Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic hernia.'
Publications
- Delayed abdominal closure after congenital diaphragmatic Hernia repair.
- Younger gestational age is associated with increased risk of adverse neurodevelopmental outcome during infancy in congenital diaphragmatic Hernia.
- Experience with Thoracoscopic Repair of Long Gap Esophageal Atresia in Neonates.
- Complete tissue coverage achieved by scaffold-based tissue engineering in the fetal sheep model of Myelomeningocele.
- Effect of single and multiple courses of maternal betamethasone on prenatal congenital lung lesion growth and fetal survival.
- In utero stem cell transplantation and gene therapy: Recent progress and the potential for clinical application.
- Neurodevelopmental outcome at one year of age in congenital diaphragmatic Hernia infants not treated with extracorporeal membrane oxygenation.
- Patient characteristics are important determinants of neurodevelopmental outcome during infancy in giant omphalocele.
- Ex utero intrapartum treatment (EXIT) in the management of cervical lymphatic malformation.
- Thoracoamniotic shunts for the management of fetal lung lesions and pleural effusions: a single-institution review and predictors of survival in 75 cases.
- Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic Hernia.
- Timing of repair of congenital diaphragmatic Hernia in patients supported by extracorporeal membrane oxygenation (ECMO).
- Systemic hypertension in giant omphalocele: An underappreciated association.
- Pulmonary hypertension in giant omphalocele infants.
- Percutaneous minimal-access fetoscopic surgery for myelomeningocele - not so minimal!
- Incidence and factors associated with sensorineural and conductive hearing loss among survivors of congenital diaphragmatic Hernia.
- In Utero Stem Cell and Gene Therapy: Current Status and Future Perspectives.
- Stable long-term mixed hematopoietic chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation.
- The contribution of hiatal hernia to severe gastroEsophageal reflux disease in patients with gastroschisis.
- IN UTERO LUNG GENE TRANSFER USING AAV AND LENTIVIRUS VECTORS IN MICE.
- Open Fetal Surgery for Central Bronchial Atresia.
- Perinatal management of congenital oropharyngeal Tumors: the ex utero intrapartum treatment (EXIT) approach.
- Longitudinal neurodevelopmental and neuromotor outcome in congenital diaphragmatic Hernia patients in the first 3 years of life.
- Fetal surgical intervention: progress and perspectives.
- In utero hematopoietic cell transplantation-recent progress and the potential for clinical application.
- Preschool neurological assessment in congenital diaphragmatic Hernia survivors: Outcome and perinatal factors associated with neurodevelopmental impairment.
- Intra-amniotic Transient Transduction of the Periderm With a Viral Vector Encoding TGFò3 Prevents Cleft Palate in Tgfò3(-/-) Mouse Embryos.
- Maternal-fetal surgery for structural malformations.
- Early Neurodevelopmental Outcome of Infants with High-Risk Fetal Lung Lesions.
- Early delivery as an alternative management strategy for selected high-risk fetal sacrococcygeal teratomas.
- Laparoscopic Hepaticoduodenostomy Versus Open Hepaticoduodenostomy for Reconstruction After Resection of Choledochal Cyst [Formula: see text].
- Genetic therapy for the fetus: a once in a lifetime opportunity.
- Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injury.
- Hepaticoduodenostomy vs hepaticojejunostomy for reconstruction after resection of choledochal cyst.
- Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary Atresia.
- Reproductive outcomes in subsequent pregnancies after a pregnancy complicated by open maternal-fetal surgery (1996-2007).
- Neurodevelopmental outcome of infants with congenital diaphragmatic Hernia prospectively enrolled in an interdisciplinary follow-up program.
- Effect of Kasai procedure on hepatic outcome in Alagille syndrome.
- Robust in vivo transduction of nervous system and neural stem cells by early gestational intra amniotic gene transfer using lentiviral vector.
- Predicting the severity of congenital high airway obstruction syndrome.
- Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling.
- Prenatal diagnosis and postnatal resection of intraabdominal enteric duplications.
- Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development of the eviscerated intestine.
- A tissue engineering approach for prenatal closure of myelomeningocele with gelatin sponges incorporating basic fibroblast growth factor.
- Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome.
- Fetal surgery: progress and perspectives.
- Maternal alloantibodies induce a postnatal immune response that limits engraftment following in utero hematopoietic cell transplantation in mice.
- Prenatal stem cell transplantation and gene therapy.
- Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy.
- Haploidentical in utero hematopoietic cell transplantation improves phenotype and can induce tolerance for postnatal same-donor transplants in the canine leukocyte adh...
- In utero meconium passage in fetuses and newborns with myelomeningocele.
- Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes.
- Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings.
- Fetal tracheal occlusion for severe congenital diaphragmatic Hernia in humans: a morphometric study of lung parenchyma and muscularization of pulmonary arterioles.
- Cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung.
- Apoptotic cell-mediated immunoregulation of dendritic cells does not require iC3b opsonization.
- In utero hematopoietic stem cell transplantation: progress toward clinical application.
- Repair of indirect Inguinal hernias by "laparoscopic joining of the edges".
- Main bronchus occlusion for treatment of congenital diaphragmatic Hernia in fetal lambs.
- Prenatal ultrasonographic gastroIntestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes.
- Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesions.
- Pulmonary vascular malformations.
- In vivo Differentiation Potential of Mesenchymal Stem Cells: Prenatal and Postnatal Model Systems.
- Efficient in vivo targeting of epidermal stem cells by early gestational intraamniotic injection of lentiviral vector driven by the keratin 5 promoter.
- Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic Hernia.
- Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice.
- Enhanced epithelial gap closure and increased angiogenesis in wounds of diabetic mice treated with adult murine bone marrow stromal progenitor cells.
- Murine bone marrow stromal progenitor cells elicit an in vivo cellular and humoral alloimmune response.
- Gene transfer to ocular stem cells by early gestational intraamniotic injection of lentiviral vector.
- Targeted gene transfer to fetal rat lung interstitium by ultrasound-guided intrapulmonary injection.
- Evidence for an immune barrier after in utero hematopoietic-cell transplantation.
- Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningocele.
- CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation.
- Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic Hernia undergoing fetal tracheal occlusion.
- Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal MRI.
- Comparison of outcomes after laparoscopic and open pyloromyotomy at a high-volume pediatric teaching hospital.
- Prenatal glucocorticoids and exogenous surfactant therapy improve respiratory function in lambs with severe diaphragmatic Hernia following fetal tracheal occlusion.
- Successful revision of portoenterostomy in an infant with biliary Atresia.
- Necrotizing enterocolitis in preterm infants--is laparotomy necessary?
- Tracheal occlusion in fetal rats alters expression of mesenchymal nuclear transcription factors without affecting surfactant protein expression.
- Cystic adenomatoid malformation of the lung: review of genetics, prenatal diagnosis, and in utero treatment.
- The regulatory role of stromal microenvironments in fetal hematopoietic ontogeny.
- Severe pulmonary hypoplasia associated with giant cervical teratomas.
- The ex utero intrapartum therapy procedure for high-risk fetal lung lesions.
- Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic Hernia.
- Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmat...
- Reconstitution of hematopoiesis following intrauterine transplantation of stem cells.
- Management of fetal Mediastinal teratoma.
- Surgeons and stem cells: a pragmatic perspective on shifting paradigms.
- Reproductive outcomes after pregnancy complicated by maternal-fetal surgery.
- Heregulin ameliorates the dystrophic phenotype in mdx mice.
- Acute cardiovascular effects of fetal surgery in the human.
- Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma.
- Fetal liver as a source of autologous progenitor cells for perinatal tissue engineering.
- Right congenital diaphragmatic Hernia: Prenatal assessment and outcome.
- Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome.
- The conceptual application of systems theory to stem cell biology: a matter of context.
- Fetal heart development in the nitrofen-induced CDH rat model: the role of mechanical and nonmechanical factors.
- Stem cells in clinical practice.
- Fetal myelomeningocele repair: short-term clinical outcomes.
Schools
University Of Arkansas College Of Medicine
Chldns Hospital Med Center
Procedures Preformed
- Appendectomy, Laparoscopic
- Appendectomy, Open
- Colectomy
- Decortication and Pleurectomy
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Conditions Treated
- Appendicitis
- Empyema
- Esophageal Fistula
- Hidradenitis
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Doctors Specialties
- Pediatric Surgery
- General Surgery
Accepted Insurances
Awards
- Philadelphia Magazine
- America's Top Doctors
- Fellow (FAAP)
- Super Doctor
- Fellow (FACS)
Education
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Cincinnati Children's Hospital Medical Center -
UCSF -
University of Arkansas for Medical Sciences College of Medicine
Hospital
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Hospital of the University of Pennsylvania -
Pennsylvania Hospital
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