Persis, Cyrus and Marlow B. Harrison Professor of Medicine, Massachusetts General Hospital

Rheumatology

Andrew D. Luster, MD practices Rheumatology. He graduated from Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University has a rank of 18 in research and a 49 in primary care He over the years received 1 awards: "Elected Member". Andrew D. Luster, MD is also a published doctor. He has 101 paper published. The most recent paper is: Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.

Publications

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• Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
• Chemokine-mediated immune responses in the female genital tract mucosa.
• The Chemokine System in Innate Immunity.
• Chemokines in Cancer.
• Chemokines and chemokine receptors: positioning cells for host defense and immunity.
• Total Chemical Synthesis and Biological Activities of Glycosylated and Non-Glycosylated Forms of the Chemokines CCL1 and Ser-CCL1.
• The Transcriptional Repressor BLIMP1 Curbs Host Defenses by Suppressing Expression of the Chemokine CCL8.
• CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo.
• BLT Humanized Mice as Model to Study HIV Vaginal Transmission.
• To B or not to B--that is the question for myocardial infarction.
• The Roles of IRF-3 and IRF-7 in Innate Antiviral Immunity against Dengue Virus.
• The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity.
• Identification of human CCR8 as a CCL18 receptor.
• Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4.
• Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation.
• Durable Knockdown and Protection From HIV Transmission in Humanized Mice Treated With Gel-formulated CD4 Aptamer-siRNA Chimeras.
• IL-23 Induces Atopic Dermatitis-Like Inflammation Instead of Psoriasis-Like Inflammation in CCR2-Deficient Mice.
• Recirculating Memory T Cells Are a Unique Subset of CD4+ T Cells with a Distinct Phenotype and Migratory Pattern.
• LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.
• Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling.
• CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4(+) T Helper 1 Cell Differentiation.
• Leukotriene b4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation.
• Chemokine guidance of central memory T cells is critical for antiviral recall responses in lymph nodes.
• HIV-infected T cells are migratory vehicles for viral dissemination.
• Rapid Evolution of HIV-1 to Functional CD8+ T Cell Responses in Humanized BLT Mice.
• Volumetric optical frequency domain imaging of pulmonary pathology with precise correlation to histopathology.
• Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation.
• 18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma.
• Eosinophils are Necessary for Pulmonary Arterial Remodeling in a Mouse Model of Eosinophilic-Inflammation Induced Pulmonary Hypertension.
• Neutrophils cascading their way to inflammation.
• Inhibiting CXCR3-Dependent CD8+ T Cell Trafficking Enhances Tolerance Induction in a Mouse Model of Lung Rejection.
• PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions.
• Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras.
• Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma.
• CXCR3 in T cell function.
• Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells.
• CXCL10 is required to maintain T-cell populations and to control parasite replication during chronic ocular toxoplasmosis.
• IL-17RA Signaling Amplifies Antibody-Induced Arthritis.
• Movement within and movement beyond: synaptotagmin-mediated vesicle fusion during chemotaxis.
• Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury.
• Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis.
• Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
• Integrins limit the Toll.
• Synaptotagmin-mediated vesicle fusion regulates cell migration.
• Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4.
• Natural killer T cells are not the predominant T cell in asthma and likely modulate, not cause, asthma.
• CXCL10 can inhibit endothelial cell proliferation independently of CXCR3.
• The emergence of basophils as antigen-presenting cells in Th2 inflammatory responses.
• Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction.
• Adiponectin deficiency increases allergic airway inflammation and pulmonary vascular remodeling.
• Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.
• Endotoxin augmented antigen-induced Th1 cell trafficking amplifies airway neutrophilic inflammation.
• Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36.
• Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture.
• A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells.
• Contribution of CCR4 and CCR8 to antigen-specific T(H)2 cell trafficking in allergic pulmonary inflammation.
• CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.
• Chapter 18. A chemokine-mediated in vivo T-cell recruitment assay.
• Allergic asthma: a tale of many T cells.
• Orchestrating the orchestrators: chemokines in control of T cell traffic.
• CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.
• Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria.
• Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis.
• Chemokines and their receptors: drug targets in immunity and inflammation.
• The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak.
• T cell trafficking in allergic asthma: the ins and outs.
• Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patien...
• An ectromelia virus protein that interacts with chemokines through their glycosaminoglycan binding domain.
• CXCL10 regulates liver innate immune response against ischemia and reperfusion injury.
• Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphoc...
• Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction.
• Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway.
• Inhibited aortic aneurysm formation in BLT1-deficient mice.
• CCR4-dependent regulatory T cell function in inflammatory bowel disease.
• Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.
• Inhibition of G alpha i2 activation by G alpha i3 in CXCR3-mediated signaling.
• Turning up the heat on HEVs.
• Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity.
• T-bet controls pathogenicity of CTLs in the heart by separable effects on migration and effector activity.
• Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression.
• Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate.
• CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis.
• Invariant natural killer T cells in bronchial asthma.
• Antiangiogenic and antitumor activities of IL-27.
• CARMA1 is critical for the development of allergic airway inflammation in a murine model of asthma.
• CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function.
• CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection.
• Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.
• A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis.
• STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells.
• Role of CXC chemokine receptor 3 pathway in renal ischemic injury.
• The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness.
• The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans.
• Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1.
• Immune cell migration in inflammation: present and future therapeutic targets.
• Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia.
• Toll-like receptor activation in the pathogenesis of systemic lupus erythematosus.
• Pathogenic T-cell recruitment into the airway in human disease.
• Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics.
• Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis.

Schools

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• Weill Cornell Medical College

• Massachusetts General Hospital

• Harvard Med School

Doctors Specialties

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• Infectious Disease Medicine
• Rheumatology

Accepted Insurances

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Awards

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• Elected Member

Education

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• Massachusetts General Hospital
• Weill Cornell Medical College of Cornell University

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