King Fahd Professor of Medicine, Oncology, Molecular Biology and Genetics, Professor of Medicine and Oncology, Johns Hopkins University School of Medicine; Chief, Division of Molecular Medicine, Department of Medicine; Director, Center for Epigenetics; Gi
Medical Genetics
Dr. Andrew S. Feinberg, MD
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Andrew Feinberg works in the field of Medical Genetics. He went to Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is one of the top medical schools in the US. Johns Hopkins University School of Medicine has a rank of 3 in research and a 29 in primary care He has 3 awards "Elected Member", "Investigator Alumnus" and "Whos Who in Medicine and Healthcare". Doctor Andrew S. Feinberg, MD is also published. He has 100 publications published. The lastest publication: "Genomic imprinting, DNA methylation, and cancer.'
Publications
- Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for Diabetic phenotypes.
- A comparison of non-integrating reprogramming methods.
- Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.
- A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1.
- GeMes, Clusters of DNA Methylation under Genetic Control, Can Inform Genetic and Epigenetic Analysis of Disease.
- Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine.
- Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays.
- Common DNA methylation alterations in multiple brain regions in autism.
- Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host.
- A third-generation method reveals cell lineage ancestry.
- Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis.
- Higher order chromatin organization in cancer.
- Reversible switching between epigenetic states in honeybee behavioral subcastes.
- Regulated noise in the epigenetic landscape of development and disease.
- Erratum: Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.
- Stem cell differentiation as a renewal-reward process: predictions and validation in the colonic crypt.
- Adaptation of the CHARM DNA methylation platform for the rat genome reveals novel brain region-specific differences.
- A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript.
- Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition.
- Increased methylation variation in epigenetic domains across cancer types.
- Significance analysis and statistical dissection of variably methylated regions.
- Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.
- Epigenomics reveals a functional genome anatomy and a new approach to common disease.
- Personalized epigenomic signatures that are stable over time and covary with body mass index.
- Addition of H19 'loss of methylation testing' for Beckwith-Wiedemann syndrome (BWS) increases the diagnostic yield.
- Comprehensive high-throughput arrays for relative methylation (CHARM).
- Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease.
- Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.
- A species-generalized probabilistic model-based definition of CpG islands.
- Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene.
- Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells.
- The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.
- A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction.
- Overlapping euchromatin/heterochromatin- associated marks are enriched in imprinted gene regions and predict allele-specific modification.
- BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.
- CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region.
- Intra-individual change over time in DNA methylation with familial clustering.
- SNP-specific array-based allele-specific expression analysis.
- DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation.
- Epigenetics at the epicenter of modern medicine.
- Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk.
- DNA methylation signatures within the human brain.
- Epigenetic specificity of loss of imprinting of the IGF2 gene in Wilms tumors.
- The commonality of plasticity underlying multipotent tumor cells and embryonic stem cells.
- Genetics and epigenetics--nature's pen-and-pencil set.
- An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.
- Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells.
- An epigenetic approach to cancer etiology.
- Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk.
- Children with idiopathic hemihypertrophy and beckwith-wiedemann syndrome have different constitutional epigenotypes associated with wilms tumor.
- Cancer epigenetics is no Mickey Mouse.
- Inheritance pattern of Beckwith-Wiedemann syndrome is heterogeneous in 291 families with an affected proband.
- Association of chromosome arm 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.
- Factors associated with preterm delivery in mOthers of children with Beckwith-Wiedemann syndrome: a case cohort study from the BWS registry.
- Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.
- Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients.
- The epigenetics of cancer etiology.
- Microdeletion of LIT1 in familial Beckwith-Wiedemann syndrome.
- Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.
- Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation.
- Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition.
- Epigenetics and assisted reproductive technology: a call for investigation.
- Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors.
- Loss of IGF2 imprinting: a potential marker of colorectal cancer risk.
- Wilms' tumor as a model for cancer biology.
- Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19.
- Epigenetic variability and the evolution of human cancer.
- Epigenetic mechanisms in human disease.
- Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2.
- SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria.
- DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms.
- Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages.
- BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein ...
- A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes.
- Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth Defects.
- Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity.
- Accurate genome-scale percentage DNA methylation estimates from microarray data.
- Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
- Redefining CpG islands using hidden Markov models.
- Genome-scale approaches to the epigenetics of common human disease.
- An integrated epigenetic and genetic approach to common human disease.
- Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA.
- Phenotypic plasticity and the epigenetics of human disease.
- Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1.
- The epigenetic progenitor origin of human cancer.
- The emerging science of epigenomics.
- The history of cancer epigenetics.
- DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
- Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors.
- Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression.
- Loss of imprinting in human cancer.
- Loss of imprinting in hepatoblastoma.
- Epigenetic effects in eukaryotic gene expression.
- A developmental context for multiple genetic alterations in Wilms'' tumor.
- Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann syndrome and various human neoplasia.
- Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour.
- Transcribed dinucleotide repeat polymorphism in the IGF2 gene.
- Simple purification of human chromosomes to homogeneity using muntjac hybrid cells.
- Genomic imprinting, DNA methylation, and cancer.
Schools
State University of New York At Buffalo
Georgia Baptist Hospital
Emory University
Eugene B Gabianelli MD
Procedures Preformed
- Cataract Removal Surgery
- Cornea Transplant
- Removal of Foreign Body from External Eye
Conditions Treated
- Aphakia and Other Disorders of Lens
- Blepharitis
- Cataract
- Corneal Ulcer
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Doctors Specialties
- Ophthalmology
- Medical Genetics
Accepted Insurances
Awards
- Elected Member
- Investigator Alumnus
- Whos Who in Medicine and Healthcare
Education
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Johns Hopkins University -
Johns Hopkins University School of Medicine
Hospital
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Johns Hopkins Hospital
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