Professor of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA
Pathology
Dr. Benhur Lee, MD
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Dr. Benhur Lee is an expert in the field of Pathology. He researched medicine at Yale University School of Medicine. Yale University School of Medicine is one of the top medical schools in the US. Yale University School of Medicine is ranked 7/57 in Research/PrimaryCare. He over the years received 20 awards: "International Advisory Board Member", "Research featured in Scientific American, "Bad Wraps on Viruses"", "Subject Matter Expert for Bioterrorism Threat Risk Assessment", "Dolph Adams Award", "Mentored Clinical Scientist Development Award (K08)", "Culpepper Biomedical Research Scholar", "Career Development Award", "Measey Foundation Research Fellowship for Clinicians", "Leonard Berwick Residency Teaching Award", "Alpha Omega Alpha", "William U. Gardner Thesis Prize", "Farr Scholar", "Howard Hughes Medical Student Training Fellowship", "Gina Finzi Memorial Student Summer Fellowship", "Magna Cum Laude Award", "Redwood Prize", "Sourisseau Prize", "Chamberlain Award", "Bolton Memorial Award" and "Phi Beta Kappa". Benhur has written publications. He has 67 publications published with PubMed. The lastest publication is: 'Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential.'
Publications
- Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential.
- Effects of singlet oxygen generated by a broad-spectrum viral fusion inhibitor on membrane nanoarchitecture.
- Evidence for Ubiquitin-Regulated Nuclear and Subnuclear Trafficking among Paramyxovirinae Matrix Proteins.
- Efficient reverse genetics reveals genetic determinants of budding and fusogenic differences between Nipah and Hendra viruses and enables real-time monitoring of viral...
- Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytia formation in endothelial cells.
- Singlet oxygen effects on lipid membranes: implications for the mechanism of action of broad-spectrum viral fusion inhibitors.
- Quantification of Entry Phenotypes of Macrophage-Tropic HIV-1 across a Wide Range of CD4 Densities.
- Functional rectification of the newly described African henipavirus fusion glycoprotein (Gh-M74a).
- The Rigid Amphipathic Fusion Inhibitor dUY11 Acts Through Photosensitization of Viruses.
- HIV provides ample PAMPs for innate immune sensing.
- A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion.
- Comparison of Viral Env Proteins From Acute and Chronic Infections of Subtype C Human Immunodeficiency Virus Type 1 Identifies Differences In Glycosylation and CCR5 Ut...
- Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.
- Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol.
- Individual N-glycans added at intervals along the stalk of the Nipah virus G protein prevent fusion, but do not block the interaction with the homologous F protein.
- Henipavirus receptor usage and tropism.
- N-glycans on the Nipah Virus Attachment Glycoprotein Modulate Fusion and Viral Entry as they Protect against Antibody Neutralization.
- Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers.
- HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry.
- Modes of paramyxovirus fusion: a Henipavirus perspective.
- Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry.
- Hendra and nipah infection: pathology, models and potential therapies.
- Interactions of human complement with virus particles containing the Nipah virus glycoproteins.
- Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors.
- The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry.
- HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism.
- Emerging paramyxoviruses: molecular mechanisms and antiviral strategies.
- Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding.
- Positive reinforcement for viruses.
- Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation.
- A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade.
- An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes.
- Redirecting lentiviral vectors pseudotyped with Sindbis virus-derived envelope proteins to DC-SIGN by modification of N-linked glycans of envelope proteins.
- HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cells.
- Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated en...
- A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model.
- A broad-spectrum antiviral targeting entry of enveloped viruses.
- A quantitative affinity-profiling system that reveals distinct CD4/CCR5 usage patterns among human immunodeficiency virus type 1 and simian immunodeficiency virus stra...
- Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4.
- Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling.
- A catalytically and genetically optimized beta-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry charact...
- MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation.
- Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities.
- Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kinetics.
- A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F).
- Evil versus 'eph-ective' use of ephrin-B2.
- Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage.
- Identification of the optimal DC-SIGN binding site on human immunodeficiency virus type 1 gp120.
- Envelope-receptor interactions in Nipah virus pathobiology.
- Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling.
- Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration through extracellular matrix.
- Two key residues in ephrinB3 are critical for its use as an alternative receptor for Nipah virus.
- N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry.
- EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus.
- Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflamm...
- Binding and transfer of human immunodeficiency virus by DC-SIGN+ cells in human rectal mucosa.
- Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection.
- DC-SIGN binds to HIV-1 glycoprotein 120 in a distinct but overlapping fashion compared with ICAM-2 and ICAM-3.
- Sugar and spice: viral envelope-DC-SIGN interactions in HIV pathogenesis.
- Human immunodeficiency virus envelope (gp120) binding to DC-SIGN and primary dendritic cells is carbohydrate dependent but does not involve 2G12 or cyanovirin binding ...
- Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity.
- Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro.
- Microbe-Host Interactions are Positively and Negatively Regulated by Galectin-Glycan Interactions.
- CRISPR/Cas9 Allows Efficient and Complete Knock-In of a Destabilization Domain-Tagged Essential Protein in a Human Cell Line, Allowing Rapid Knockdown of Protein Funct...
- Evidence for henipavirus spillover into human populations in Africa.
- Molecular Composition and Volatility of Organic Aerosol in the Southeastern U.S.: Implications for IEPOX Derived SOA.
Schools
Yale University
Hospital Of The University Of Pennsylvania
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Awards
- International Advisory Board Member
- Research featured in Scientific American, "Bad Wraps on Viruses"
- Subject Matter Expert for Bioterrorism Threat Risk Assessment
- Dolph Adams Award
- Mentored Clinical Scientist Development Award (K08)
- Culpepper Biomedical Research Scholar
- Career Development Award
- Measey Foundation Research Fellowship for Clinicians
- Leonard Berwick Residency Teaching Award
- Alpha Omega Alpha
- William U. Gardner Thesis Prize
- Farr Scholar
- Howard Hughes Medical Student Training Fellowship
- Gina Finzi Memorial Student Summer Fellowship
- Magna Cum Laude Award
- Redwood Prize
- Sourisseau Prize
- Chamberlain Award
- Bolton Memorial Award
- Phi Beta Kappa
Education
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University of Pennsylvania Health System -
Yale University School of Medicine
Hospital
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Ronald Reagan UCLA Medical Center
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