Physician
Internal Medicine
Dr. Benjamin G. Neel, MD
Dr. Benjamin G. Neel is an expert in the field of Internal Medicine. He studied medicine at Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University is ranked 18/49 in Research/PrimaryCare. Benjamin Neel has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.'
Publications
- Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.
- PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.
- Diverse Levels of Sequence Selectivity and Catalytic Efficiency of Protein-Tyrosine Phosphatases.
- Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: Potential role of PPARγ
- Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
- Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.
- Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca(2+) homeostasis.
- Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice.
- Regulation of Signaling at Regions of Cell-Cell Contact by Endoplasmic Reticulum-Bound Protein-Tyrosine Phosphatase 1B.
- Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance.
- TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
- Epithelial Protein-Tyrosine Phosphatase 1B Contributes to the Induction of Mammary Tumors by HER2/Neu But Is Not Essential for Tumor Maintenance.
- Global proteomic assessment of the classical protein-tyrosine phosphatome and "redoxome".
- SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver.
- G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase.
- Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
- Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells.
- Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2.
- Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.
- MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.
- Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer.
- Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2.
- PTP1B regulates Eph receptor function and trafficking.
- Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.
- Regulation of kidney development by Shp2: an unbiased stereological analysis.
- A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
- Tumor-initiating cells are rare in many human tumors.
- Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis.
- Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor...
- Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene.
- Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.
- Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.
- Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
- Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
- Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.
- Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.
- Noonan syndrome/leukemia-associated gain-of-function mutations in SHP-2 phosphatase (PTPN11) enhance cell migration and angiogenesis.
- The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
- Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.
- Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and...
- SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients.
- Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
- Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.
- Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
- B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.
- Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome.
- Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.
- ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.
- Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B.
- Nonreceptor protein-tyrosine phosphatases in immune cell signaling.
- Germline gain-of-function mutations in SOS1 cause Noonan syndrome.
- FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.
- SHP1 phosphatase-dependent T cell inhibition by CEACAM1 adhesion molecule isoforms.
- SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth.
- The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway.
- Neuronal PTP1B regulates body weight, adiposity and leptin action.
- PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects.
- Stops along the RAS pathway in human genetic disease.
- An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival.
- Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
- Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src complex and promote cell migration.
- A role for the scaffolding adapter GAB2 in breast cancer.
- A nomenclature for signal regulatory protein family members.
- Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes.
- Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.
- PTP-1B is an essential positive regulator of platelet integrin signaling.
- Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase.
- Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.
- Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.
- The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death.
- Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.
- Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.
- Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.
- Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia.
- CD22 is a functional ligand for SH2 domain-containing protein-tyrosine phosphatase-1 in primary T cells.
- Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.
- Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does no...
- CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity.
- Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands.
- Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
- Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
- Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.
- Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice.
- SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase.
- Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors.
- Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
- Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.
- SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.
- Increased expression of epidermal growth factor receptor induces sequestration of extracellular signal-related kinases and selective attenuation of specific epidermal ...
- Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.
- Critical role for Gab2 in transformation by BCR/ABL.
- Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling.
- Mathematical models of protein kinase signal transduction.
- PTP1B regulates leptin signal transduction in vivo.
- Imaging sites of receptor dephosphorylation by PTP1B on the surface of the endoplasmic reticulum.
- The role of Shp2 (PTPN11) in cancer.
- A suggested role for mitochondria in Noonan syndrome.
- Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface.
- The tyrosine phosphatase Shp2 (PTPN11) in cancer.
- Tyrosine phosphatase SHP-2 is a mediator of activity-dependent neuronal excitotoxicity.
Schools
Weill Cornell Medical College
Beth Israel Hospital
Doctors Specialties
- Internal Medicine
Accepted Insurances
Education
-
Beth Israel Deaconess Medical Center -
Weill Cornell Medical College of Cornell University
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