Professor, Internal Medicine, University of Texas Medical School, Houston
Nephrology
Bruce Kone practices Nephrology. He graduated from University of Florida College of Medicine. University of Florida College of Medicine has a rank of 43 in research and a 78 in primary care He over the years received 37 awards: "Best Doctors in America", "Marquis Whos Who in the World", "Marquis Whos Who in America", "Deans Excellence Award in Teaching", "Marquis Whos Who in Medicine and Healthcare", "Outstanding Teaching Attending", "Top 10 in the World, 3 events", "Outstanding Specialty Attending", "FIrst Place National Ranking", "Special Recognition", "Member", "National or International Honor in Research", "National or International Honors in Clinical Service", "Elected Inaugural Fellow", "Outstanding Achievements in Research", "Elected to Fellowship", "Faculty Merit Teaching Award", "Advanced to Fellowship", "Established Investigatorship Award", "First", "Young Investigator Travel Award", "Clinical Investigation", "Watson Clinic for outstanding scientific contribution by a medical student", "Clinical Investigator", "Individual National Research Service", "Faculty Research for outstanding research by a medical student", "Honors in Research", "Medical Student Research Fellowship", "Alpha Omega Alpha Honor Medical Society", "Americas Top Physicians", "First Place World Ranking", "Fellow (ASNF)", "Fellow (FAAAS)", "Marquis Whos Who in Science and Engineering", "Fellow (FAHA)", "Fellow (FACP)" and "Fellow (FCP)". Bruce Kone is also a published doctor. He has 101 paper published. The most recent paper is: Molecular approaches to renal physiology and therapeutics. Bruce Kone accepts Medicare payments and is registered with Medicare.gov.
Publications
- Aldosterone Reprograms Promoter Methylation To Regulate αENaC Transcription In Collecting Duct.
- Epigenetics and the control of the collecting duct epithelial sodium channel.
- Sp1 Trans-activates and Is Required for Maximal Aldosterone Induction of the αENaC Gene in Collecting Duct Cells.
- Molecular Regulation of Trypanosoma congolense-Induced Nitric Oxide Production in Macrophages.
- An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the ?ENaC gene.
- Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure Response to hydrochlorothiazide.
- Intestinal ischemic preconditioning after ischemia/reperfusion injury in rat intestine: profiling global gene expression patterns.
- CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells.
- AF17 competes With AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha.
- Sirtuin 1 functionally and physically interacts With disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct.
- 2009 Southern Society For Clinical Investigation presidential address: opportunity knocks.
- Sp1 trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene.
- Narrative review: evolving concepts in potassium homeostasis and Hypokalemia.
- A different perspective on admission decisions.
- Epigenetics and the control of epithelial sodium channel expression in collecting duct.
- Pretreatment With bone morphogenetic protein-7 (BMP-7) mimics ischemia preconditioning following intestinal ischemia/reperfusion injury in the intestine and liver.
- Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha.
- New mechanisms for transcriptional repression of ENaC And iNOS.
- Myelodysplastic syndrome manifesting as Sweet's Syndrome and bronchiolitis obliterative organizing pneumonia.
- NO break-ins at water gate.
- Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner.
- Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene.
- Aldosterone-sensitive repression of ENaCalpha transcription by a histone H3 lysine-79 methyltransferase.
- Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells.
- Src activation of NF-kappaB augments IL-1beta-induced nitric oxide production in mesangial cells.
- Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury.
- Expression profile of a human inducible nitric oxide synthase promoter reporter in transgenic mice during endotoxemia.
- Hypermethylation of the inducible nitric-oxide synthase gene promoter inhibits its transcription.
- Alpha-melanocyte stimulating hormone protects against H2O2-induced inhibition of wound restitution in IEC-6 cells via a Syk kinase- and NF-kappabeta-dependent mechanism.
- CREB trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene.
- Nitric oxide synthesis in the Kidney: isoforms, biosynthesis, and functions in health.
- In vivo expression profile of a H+-K+-ATPase alpha2-subunit promoter-reporter transgene.
- Lipopolysaccharide-induced changes in rat gastric H/K-ATPase expression.
- The STAT3 DNA-binding domain mediates interaction With NF-kappaB p65 and iuducible nitric oxide synthase transrepression in mesangial cells.
- Hypothermia protects against gut ischemia/reperfusion-induced impaired intestinal transit by inducing heme oxygenase-1.
- Delayed administration of alpha-melanocyte-stimulating hormone or combined therapy With BAY 11-7085 protects against gut ischemia-reperfusion injury.
- Protein interactions With nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide.
- Effects of NF-kappa B inhibition on mesenteric ischemia-reperfusion injury.
- Insulin-stimulated cyclic guanosine monophosphate inhibits vascular smooth muscle cell migration by inhibiting Ca/calmodulin-dependent protein kinase II.
- Proteomic analysis of S-nitrosylated proteins in mesangial cells.
- NF-kappaB inhibits transcription of the H(+)-K(+)-ATPase alpha(2)-subunit gene: role of histone deacetylases.
- USF-1 and USF-2 trans-repress IL-1beta-induced iNOS transcription in mesangial cells.
- Histone deacetylases augment cytokine induction of the iNOS gene.
- Intraischemic hypothermia differentially modulates oxidative stress proteins during mesenteric ischemia/reperfusion.
- Alpha-melanocyte-stimulating hormone protects against mesenteric ischemia-reperfusion injury.
- Proteomic analysis reveals novel protein targets of S-nitrosylation in mesangial cells.
- Advances in genetic detection of Kidney disease.
- Structure and regulation of the mDot1 gene, a mouse histone H3 methyltransferase.
- Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting With nuclear factor kappaB.
- Differential induction of PPAR-gamma by luminal glutamine and iNOS by luminal arginine in the rodent postischemic small bowel.
- Protein-protein interactions involving inducible nitric oxide synthase.
- How will gene therapy apply to the Kidney in the 21st century?
- Protein-protein interactions controlling nitric oxide synthases.
- alpha-MSH inhibits induction of C/EBPbeta-DNA binding activity and NOS2 gene transcription in macrophages.
- Sch-28080 depletes intracellular ATP selectively in mIMCD-3 cells.
- Post-injury multiple organ Failure: the role of the gut.
- Specific association of nitric oxide synthase-2 With Rac isoforms in activated murine macrophages.
- Molecular biology of natriuretic peptides and nitric oxide synthases.
- Structure, promoter analysis, and chromosomal localization of the murine H(+)/K(+)-ATPase alpha 2 subunit gene.
- Renal H,K-ATPase: structure, function and regulation.
- Functional expression of the colonic H+,K+-ATPase alpha-subunit. Pharmacologic properties and assembly With X+,K+-ATPase beta-subunits.
- Macrophages and Chronic renal allograft nephropathy.
- Effects of Chronic hypokalemia on renal expression of the "gastric" H(+)-K(+)-ATPase alpha-subunit gene.
- A 'BOLD' new approach to Renal oxygen economy.
- Biosynthesis and homeostatic roles of nitric oxide in the normal Kidney.
- Nitric oxide in renal health and Disease.
- A novel N-terminal splice variant of the rat H+-K+-ATPase alpha2 subunit. Cloning, functional expression, and renal adaptive response to Chronic hypokalemia.
- Molecular approaches to Renal physiology and therapeutics.
- CCAAT/enhancer binding protein-beta trans-activates murine nitric oxide synthase 2 gene in an MTAL cell line.
- Nitric oxide inhibits transcription of the Na+-K+-ATPase alpha1-subunit gene in an MTAL cell line.
- Localization and regulation of nitric oxide synthase isoforms in the Kidney.
- Silver ion (Ag+)-induced increases in cell membrane K+ and Na+ permeability in the Renal proximal tubule: reversal by thiol reagents.
- Cellular pathways of potassium transport in Renal inner medullary collecting duct.
- Coordinated regulation of intracellular K+ in the proximal tubule: Ba2+ blockade down-regulates the Na+,K+-ATPase and up-regulates two K+ permeability pathways.
- Endothelin, a peptide inhibitor of Na(+)-K(+)-ATPase in intact Renaltubular epithelial cells.
- Extracellular Na+ electrode for monitoring net Na+ flux in cell suspensions.
- Early effects of uranyl nitrate on respiration and K+ transport in rabbit proximal tubule.
- Locally formed dopamine inhibits Na+-K+-ATPase activity in rat Renal cortical tubule cells.
- A cell biologist's perspective on sites of Na,K-ATPase regulation.
- Influence of Na+ intake on dopamine-induced inhibition of Renal cortical Na(+)-K(+)-ATPase.
- Mitochondrial injury: an early event in cisplatin toxicity to Renal proximal tubules.
- Modulation of osmolytes in MDCK cells by solutes, inhibitors, and vasopressin.
- Succinate alters respiration, membrane potential, and intracellular K+ in proximal tubule.
- Hypertension and Renal dysfunction in bone marrow transplant recipients.
- Acute renal failure produced by combining cyclosporine and brief renal ischemia in the Munich Wistar rat.
- Acute renal failure following percutaneous transhepatic cholangiography. A retrospective study.
- In situ hybridization localization of mRNA encoding inducible nitric oxide synthase in rat Kidney.
- Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat Kidney.
- Identification of constitutive and inducible forms of nitric oxide synthase in human platelets.
- Cytokines activate inducible nitric oxide synthase gene transcription in inner medullary collecting duct cells.
- Expression and cellular localization of mRNA encoding the "gastric" isoform of H(+)-K(+)-ATPase alpha-subunit in rat Kidney.
- Segmental localization of mRNAs encoding Na(+)-K(+)-ATPase alpha- and beta-subunit isoforms in rat Kidney using RT-PCR.
- Differential expression and cellular distribution of mRNAs encoding alpha- and beta-isoforms of Na(+)-K(+)-ATPase in rat Kidney.
- Differential actions of cisplatin on Renal proximal tubule and inner medullary collecting duct cells.
- Renal blood flow, glomerular filtration rate, and renal morphology in cyclosporine-induced Acute renal failure in Munich-Wistar rats.
- Early renal pathophysiology in an Acute model of cyclosporine nephrotoxicity in rats.
- Renal morphology and function and urine electrolytes in experimental Acute renal failure produced by cyclosporine and ischemia.
- Reflections on use of the Renal biopsy as the "gold standard" in distinguishing transplant rejection from cyclosporine nephrotoxicity.
- Ultrastructure of the thick ascending limb of Henle in the rat Kidney.
- Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line.
Schools
University Of Florida College Of Medicine
Johns Hopkins Hospital
Brigham Womens Hospital
Procedures Preformed
- Hemodialysis
- Peritoneal Dialysis
Conditions Treated
- Acidosis
- Acute Kidney Failure
- Alkalosis
- Amyloidosis
- View All
Doctors Specialties
Accepted Insurances
Awards
- Best Doctors in America
- Marquis’ Who’s Who in the World
- Marquis’ Who’s Who in America
- Dean’s Excellence Award in Teaching
- Marquis’ Who’s Who in Medicine and Healthcare
- Outstanding Teaching Attending
- Top 10 in the World, 3 events
- Outstanding Specialty Attending
- FIrst Place National Ranking
- Special Recognition
- Member
- National or International Honor in Research
- National or International Honors in Clinical Service
- Elected Inaugural Fellow
- Outstanding Achievements in Research
- Elected to Fellowship
- Faculty Merit Teaching Award
- Advanced to Fellowship
- Established Investigatorship Award
- First
- Young Investigator Travel Award
- Clinical Investigation
- Watson Clinic for outstanding scientific contribution by a medical student
- Clinical Investigator
- Individual National Research Service
- Faculty Research for outstanding research by a medical student
- Honors in Research
- Medical Student Research Fellowship
- Alpha Omega Alpha Honor Medical Society
- America’s Top Physicians
- First Place World Ranking
- Fellow (ASNF)
- Fellow (FAAAS)
- Marquis’ Who’s Who in Science and Engineering
- Fellow (FAHA)
- Fellow (FACP)
- Fellow (FCP)
Education
-
Brigham and Women's Hospital
-
Johns Hopkins University
-
University of Florida College of Medicine
Hospital
-
University of Texas M.D. Anderson Cancer Center
Drug Facts
| NPI NUMBER |
|
1568495539 |
| NPPES Provider LastName |
|
KONE |
| NPPES Provider FirstName |
|
BRUCE |
| NPPES Provider ZIPCode |
|
326103003 |
| NPPES Provider State |
|
FL |
| Specialty Description |
|
Nephrology |
| Total Claim Count |
|
1609.0 |
| Distinct Opioid Count |
|
1.0 |
| Opioid Claim Count |
|
100.0 |
| Percent Opioid Claims |
|
6.22 |
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Medicare Facts
| National Provider Identifier [NPI] |
1568495539 |
| Last Name Of The Provider |
KONE |
| First Name Of The Provider |
BRUCE |
| View All |
|
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