Professor of Medicine, Massachusetts General Hospital
Infectious Disease
Dr. Bruce D. Walker, MD
Dr. Bruce D. Walker is an expert in the field of Infectious Disease. He went to medical school at Case Western Reserve University School of Medicine. He received awards:"Elected Member" and "Investigator". Bruce Walker is a published physician. He has 103 publications published. The most current publication "Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16." Doctor Bruce D. Walker, MD accepts all Medicare patients.
Publications
- Immunization of HIV-1-infected Persons with Autologous Dendritic Cells Transfected with mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Cl...
- CXCL13 is a plasma biomarker of germinal center activity.
- Population-level Immune-mediated Adaptation in HIV-1 Polymerase during the North American Epidemic.
- Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Co...
- Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.
- A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.
- The breadth of expandable memory CD8+ T cells inversely correlates with residual viral loads in HIV elite controllers.
- HIV-1 integration landscape during latent and active infection.
- Dysfunctional HIV-Specific CD8(+) T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis.
- HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes.
- Impaired Nef function is associated with early control of HIV-1 viremia.
- Long-term Antiretroviral Treatment Initiated in Primary HIV-1 Infection Affects the Size, Composition and Decay Kinetics of the Reservoir of HIV-1 Infected CD4 T Cells.
- A Cell-Intrinsic Inhibitor of HIV-1 Reverse Transcription in CD4(+) T Cells from Elite Controllers.
- Genotypic and functional impact of HIV-1 adaptation to its host population during the North American epidemic.
- LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection.
- HIV-1 infection impairs regulatory T cell suppressive capacity on a per-cell basis.
- Engineering cellular resistance to HIV.
- Profiling human antibody responses by integrated single-cell analysis.
- HIV-1 persistence in CD4(+) T cells with stem cell-like properties.
- Programming CMV for vaccine vector design.
- Association of HLA-DRB1-restricted CD4(+) T cell responses with HIV immune control.
- Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells.
- Unravelling the mechanisms of durable control of HIV-1.
- Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls.
- Influence of HLA-C expression level on HIV control.
- Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design.
- High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
- Reactivation of Latent HIV-1 by Inhibition of BRD4.
- The T-Cell Response to HIV.
- HIV and HLA Class I: An Evolving Relationship.
- Identification of HIV-1-specific regulatory T cells using HLA class II tetramers.
- Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African Americans.
- TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
- Prospective Monitoring Reveals Dynamic Levels of T Cell Immunity to Mycobacterium Tuberculosis in HIV Infected Individuals.
- Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses.
- Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals.
- Characteristics and Outcomes of Initial Virologic Suppressors during Analytic Treatment Interruption in a Therapeutic HIV-1 gag Vaccine Trial.
- Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.
- Immunogenetics of Spontaneous Control of HIV.
- Differential regulation of TLR pathways in acute and chronic HIV-1 infection.
- CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control.
- Definition of the viral targets of protective HIV-1-specific T cell responses.
- Lack of association between HLA class II alleles and in vitro replication capacities of recombinant viruses encoding HIV-1 subtype C Gag-protease from chronically infe...
- HLA-B*57 micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure and HIV immune control.
- HIV-specific CD4 T cell responses to different viral proteins have discordant associations with viral load and clinical outcome.
- A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis.
- Limited Immunogenicity of HIV CD8+ T-Cell Epitopes in Acute Clade C Virus Infection.
- Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding.
- High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.
- From the Cover: Coordinate linkage of HIV evolution reveals regions of immunological vulnerability.
- Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells.
- Epithelial adhesion molecules can inhibit HIV-1-specific CD8? T-cell functions.
- Impairment of CD1d-Restricted Natural Killer T Cells in Chronic HIV Type 1 Clade C Infection.
- Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection.
- Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression.
- CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21.
- Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.
- Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10.
- CD8(+) T Cell Polyfunctionality Profiles in Progressive and Nonprogressive Pediatric HIV Type 1 Infection.
- Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.
- Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes.
- Reduced replication capacity of NL4-3 recombinant viruses encoding reverse transcriptase-integrase sequences from HIV-1 elite controllers.
- Lack of detectable HIV-1-specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals.
- A Novel Immunodominant CD8+ T Cell Response Restricted by a Common HLA-C Allele Targets a Conserved Region of Gag HIV-1 Clade CRF01_AE Infected Thais.
- Permanent pacing for late-onset atrioventricular block in patients with heart transplantation: a single center experience.
- Moving ahead an HIV vaccine: Use both arms to beat HIV.
- HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function.
- A molecular assay for sensitive detection of pathogen-specific T-cells.
- Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection.
- HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodo...
- Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
- Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.
- Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
- Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
- Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers.
- Impaired replication capacity of acute/early viruses in persons who become HIV controllers.
- Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control.
- Alterations in natural killer cell receptor profiles during HIV type 1 disease progression among chronically infected South African adults.
- IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines.
- CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription.
- Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics.
- Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate.
- HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.
- Functional and genetic analysis of coreceptor usage by dualtropic HIV-1 subtype C isolates.
- Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
- Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters.
- Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.
- Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition.
- IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.
- Left ventricular mechanical assist devices and cardiac device interactions: an observational case series.
- Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.
- Tracking the culprit: HIV-1 evolution and immune selection revealed by single-genome amplification.
- A step ahead on the HIV collaboratory.
- PD-1 and CTLA-4 inhibitory cosignaling pathways in HIV infection and the potential for therapeutic intervention.
- Lack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population.
- The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression.
- HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clustering.
- Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipients.
- Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes.
- HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers.
- Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16.
- Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression.
Schools
Case Western Reserve University School of Medicine
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
- Investigator
Education
-
Massachusetts General Hospital -
Case Western Reserve University School of Medicine
Hospital
-
Massachusetts General Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1770571572 |
| Last Name Of The Provider | WALKER |
| First Name Of The Provider | BRUCE |
| View All |
Similar Doctors
|
Dr. Sybil A. Tasker, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Barbra M. Blair, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Abdul Basit, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Robert Colgrove, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. John A. Brusch, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Stephen Zinner, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. John Tully, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Rebeca M. Plank, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. David M. Davidson, MD |
|
|
Dr. Thomas G. Evans, MD |
|
|
Dr. David P. Del Bello, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Amy E. Colson, MD
This Doctor is OpenDoctor Recommended.
|