Regents Professor, Pediatrics, University of Minnesota Medical School
Pediatric Hematology & Oncology
Dr. Bruce R. Blazar, MD
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Doctor Bruce R. Blazar, MD works in the field of Pediatric Hematology & Oncology. He went to medical school at Albany Medical College. He over the years received 1 awards: "Elected Member". Bruce Blazar is a published doctor as well. He has 101 publications published. The latest was: Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation?
Publications
- Circulating T follicular helper cells with increased function during chronic graft-versus-host-disease.
- Impact of Allele-Level HLA Mismatch on Outcomes in Recipients of Double Umbilical Cord Blood Transplantation.
- Preclinical models of acute and chronic graft-versus-host disease: how predictive are they for a successful clinical translation?
- CD56(dim)CD57(+)NKG2C(+) NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT.
- IL-15 Trispecific Killer Engagers (TriKEs) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing In Vivo Expansion, and Enhanced Function.
- In Vitro T-Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination.
- A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A P...
- Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile and clinical effect.
- Inflammasome effects in GvHD.
- Evaluation of TCR Gene Editing achieved by TALENs, CRISPR/Cas9 and megaTAL nucleases.
- GvHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells.
- Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity.
- Strategies to inhibit alloantibody production in alloprimed murine recipients of hematopoietic stem cell grafts.
- A Refined Risk Score for Acute Graft-versus-Host Disease that Predicts Response to Initial Therapy, Survival, and Transplant-Related Mortality.
- Role of Transgene Regulation in Ex Vivo Lentiviral Correction of Artemis Deficiency.
- The IL-33/ST2 axis augments effector T cell responses during acute GVHD.
- B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality.
- Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation.
- Cutting Edge: Identification of Autoreactive CD4+ and CD8+ T Cell Subsets Resistant to PD-1 Pathway Blockade.
- Circulating Angiogenic Factors associated with Response and Survival in Patients with Acute Graft-versus-Host Disease: Results from Blood and Marrow Transplant Clinica...
- Reprint of: B cells in chronic graft-versus-host disease.
- B Cells in Chronic Graft-versus-Host Disease.
- Therapeutic Benefit of Bortezomib on Acute Graft-versus-Host Disease Is Tissue Specific and Is Associated with Interleukin-6 Levels.
- Fanconi Anemia Gene Editing by the CRISPR/Cas9 System.
- A Phase II Study of Bortezomib Plus Prednisone for Initial Therapy of Chronic Graft-versus-Host Disease.
- Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.
- Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.
- Notch Signaling at Later Stages of NK Cell Development Enhances KIR Expression and Functional Maturation.
- Treatment of chronic graft versus host disease with bortezomib.
- sdf1 expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish.
- Increased T follicular helper cells and germinal center B cells are required for chronic GVHD (cGVHD) and bronchiolitis obliterans.
- Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice.
- Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T cell responses through the PD-1/PD-L1 axis.
- Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein.
- Functional NK Cell Repertoires Are Maintained through IL-2Rα and Fas Ligand.
- CD16xCD33 bispecific killer cell engager (BiKE) activates NK cells from MDS patients against primary MDS and MDSC CD33+ targets.
- Prevention of Graft-versus-Host Disease by Adoptive T Regulatory Therapy Is Associated with Active Repression of Peripheral Blood Toll-Like Receptor 5 mRNA Expression.
- Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GvHD.
- Post-Transplantation B Cell Activating Factor and B Cell Recovery before Onset of Chronic Graft-versus-Host Disease.
- Patient-Specific Naturally Gene-Reverted Induced Pluripotent Stem Cells in Recessive Dystrophic Epidermolysis Bullosa.
- Higher therapeutic CsA levels early post transplantation reduces risk of acute GVHD and improves survival.
- Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy.
- DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo.
- Host programmed death ligand-1 is dominant over programmed death ligand-2 expression in regulating graft-versus-host disease lethality.
- Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice.
- Adoptive transfer of umbilical cord blood-derived regulatory T cells and early viral reactivation.
- Influenza infection results in local expansion of memory CD8(+) T cells with antigen-nonspecific phenotype and function.
- Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration.
- Minicircle DNA is Superior to Plasmid DNA in Eliciting Antigen-specific CD8(+) T-cell Responses.
- An inherently bifunctional subset of foxp3(+) T helper cells is controlled by the transcription factor eos.
- TALEN-based Gene Correction for Epidermolysis Bullosa.
- Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease.
- Bone Marrow Stromal and Vascular Smooth Muscle Cells Have Chemosensory Capacity via Bitter Taste Receptor Expression.
- Impact of ABO-mismatch on risk of GVHD after umbilical cord blood transplantation.
- A Phase I Study of Alemtuzumab for Therapy of Steroid-Refractory Chronic Graft-versus-Host Disease.
- Lineage relationships of human IL-22 producing CD56+ ROR?t+ innate lymphoid cells and conventional NK cells.
- A randomized trial of one versus two doses of influenza vaccine after allogeneic transplantation.
- Keratinocytes from Induced Pluripotent Stem Cells in Junctional Epidermolysis Bullosa.
- Bortezomib-based graft-versus-host disease prophylaxis in HLA-mismatched unrelated donor transplantation.
- In Memoriam: Thea Friedman.
- FTY720 Markedly Increases Alloengraftment but Does Not Eliminate Host Anti-Donor T Cells that Cause Graft Rejection on Its Withdrawal.
- Cooking Up Tolerance: Has a New Recipe Been Created?
- Prolonged subcutaneous administration of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced hematologic...
- Contrasting acute graft-versus-host-disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells.
- Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus.
- Factors predicting single-unit predominance after double umbilical cord blood transplantation.
- Nonhuman primate transplant models finally evolve: detailed immunogenetic analysis creates new models and strengthens the old.
- Delineation of antigen-specific and antigen-nonspecific CD8+ memory T-cell responses after cytokine-based cancer immunotherapy.
- Successful Remission Rates and Survival after Lymphodepleting Chemotherapy for Relapsed Hematologic Malignancies Post Allogeneic Hematopoietic Cell Transplant.
- Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes.
- Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans.
- Resurrecting the recalcitrant T-cell.
- Peritransplant palifermin use and lymphocyte recovery after T-cell replete, matched related allogeneic hematopoietic cell transplantation.
- Zebrafish stromal cells have endothelial properties and support hematopoietic cells.
- Oxygen is a Master Regulator of the Immunogenicity of Primary Human Glioma Cells.
- Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?
- Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.
- Synthetic Zinc Finger Nuclease Design and Rapid Assembly.
- IDO in human gut graft-versus-host disease.
- Clinical perspectives for regulatory T cells in transplantation tolerance.
- Physiologic Control of IDO Competence in Splenic Dendritic Cells.
- Evidence for early fibrosis and increased airway resistance in bone marrow transplant recipient mice deficient in MMP12.
- Sleeping Beauty-mediated correction of Fanconi anemia type C.
- PKC-? function at the immunological synapse: prospects for therapeutic targeting.
- Opposing Effects of CD70 Costimulation during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection of Mice.
- Skeletal muscle contractile function and neuromuscular performance in Zmpste24 (-/-) mice, a murine model of human progeria.
- The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo.
- The Programmed Death-1 Ligand 1:B7-1 Pathway Restrains Diabetogenic Effector T Cells In Vivo.
- Stromal cell-derived factor-1 (SDF-1) and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplant.
- Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity.
- Stem Cell Gene Therapy for Fanconi Anemia: Report from the 1st International Fanconi Anemia Gene Therapy Working Group Meeting.
- Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.
- miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1.
- Transplantation of Human Hematopoietic Cells for Extracellular Matrix Protein Deficiency in Epidermolysis Bullosa.
- Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independent of MHC.
- Development of IL-22-producing NK lineage cells from umbilical cord blood hematopoietic stem cells in the absence of secondary lymphoid tissue.
- Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa.
- Natural killer-cell differentiation by myeloid progenitors.
- Roles of CD28, CTLA4, and Inducible Costimulator Costimulation in Acute Graft-versus-Host Disease in Mice.
- Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new.
Schools
Albany Medical College
University Of Minnesota
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Elected Member
Education
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University of Minnesota at Fairview -
Albany Medical College
Hospital
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University of Minnesota Medical Center, Fairview
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