Associate Professor, Pathology and Laboratory Medicine, Perelman School of Medicine
Pathology
Dr. Bruce Sachais, MD
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Doctor Bruce Sachais, MD practices Pathology. He graduated from Washington University School of Medicine in St. Louis. He over the years received 1 awards: "CMS Meaningful Use Stage 1 Certification". Bruce Sachais has written publications. He has 52 publications published with PubMed. The lastest publication is: 'Identification of the site in the substance P (NK-1) receptor for modulation of peptide binding by sulfhydryl reagents.' Bruce Sachais is registered with Medicare and accepts Medicare payments.
Publications
- Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection.
- Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia.
- Therapeutic plasma exchange and immunosuppressive therapy in a patient with anti-GAD antibody-related epilepsy: Quantification of the antibody response.
- Transfusion of 28-day-old leucoreduced or non-leucoreduced stored red blood cells induces an inflammatory response in healthy dogs.
- Novel diagnostic assays for heparin-induced thrombocytopenia.
- Investigation of a potential protective mechanism against heparin-induced thrombocytopenia in patients on chronic intermittent hemodialysis.
- Long-term clinical results of microsomal triglyceride transfer protein inhibitor use in a patient with homozygous familial hypercholesterolemia.
- Shared VH1-46 gene usage by pemphigus vulgaris autoantibodies indicates common humoral immune responses among patients.
- Molecular basis for the species selectivity of the substance P antagonist CP-96,345.
- Both extracellular and transmembrane residues contribute to the species selectivity of the neurokinin-1 receptor antagonist WIN 51708.
- Residue 78 in the second transmembrane domain of the neurokinin-1 receptor is important in coupling high affinity agonist binding to multiple second messenger responses.
- Photoaffinity labeling of mutant neurokinin-1 receptors reveals additional structural features of the substance P/NK-1 receptor complex.
- Ligand binding kinetics of substance P and neurokinin A receptors stably expressed in Chinese hamster ovary cells and evidence for differential stimulation of inositol...
- Identification of the site in the substance P (NK-1) receptor for modulation of peptide binding by sulfhydryl reagents.
- The costs of disease.
- A role for prospective monitoring of plasma transfusion.
- Platelet-endothelial interactions in atherosclerosis.
- Cryopreservation of canine platelets.
- The alpha-defensins stimulate proteoglycan-dependent catabolism of low-density lipoprotein by vascular cells: a new class of inflammatory apolipoprotein and a possible...
- A peptide derived from the nonreceptor binding region of urokinase plasminogen activator (uPA) inhibits tumor progression and angiogenesis and induces tumor cell death...
- Urokinase-derived peptides regulate vascular smooth muscle contraction in vitro and in vivo.
- Laboratory costs in the context of disease.
- Blood transfusion costs by diagnosis-related groups in 60 university hospitals in 1995.
- Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model.
- Novel interactions between urokinase and its receptor.
- Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA.
- A region in domain II of the urokinase receptor required for urokinase binding.
- Defensin promotes the binding of lipoprotein(a) to vascular matrix.
- Low-density lipoprotein apheresis reduces platelet factor 4 on the surface of platelets: a possible protective mechanism against heparin-induced thrombocytopenia and t...
- Increased risk of citrate reactions in patients with multiple myeloma during peripheral blood stem cell leukapheresis.
- Anaphylactoid-like reactions in a patient with HyperLp(a)lipidemia undergoing LDL apheresis with dextran sulfate adsorption and herbal therapy with the spice turmeric.
- Evidence-based practice guidelines for plasma transfusion.
- Canine platelet transfusions.
- Elimination of platelet factor 4 (PF4) from platelets reduces atherosclerosis in C57Bl/6 and apoE-/- mice.
- The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow.
- Chemokines and thrombogenicity.
- Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly.
- Long-term effects of LDL apheresis in patients with severe hypercholesterolemia.
- PF4/heparin complexes are T cell-dependent antigens.
- Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet factor 4 through LRP in an NF-kappaB-dependent manner.
- Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.
- Interactions of platelet factor 4 with the vessel wall.
- Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters.
- The kringle stabilizes urokinase binding to the urokinase receptor.
- Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment.
- Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets.
- Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells.
- Use of plasma exchange, steroids, and anticoagulation in a patient with multiple arterial thromboses and IgM anticardiolipin antibodies.
- Platelet factor 4 binds to low-density lipoprotein receptors and disrupts the endocytic machinery, resulting in retention of low-density lipoprotein on the cell surface.
- Comparative costs of treating adults and children within selected diagnosis-related groups.
- Effect of disease complications on hospital costs.
Schools
Washington State University
Doctors Specialties
- Clinical Pathology
- Pathology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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University of Pennsylvania Health System -
Washington University School of Medicine in St. Louis
Hospital
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Hospital of the University of Pennsylvania -
Penn Presbyterian Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1669417747 |
| Last Name Of The Provider | SACHAIS |
| First Name Of The Provider | BRUCE |
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