Professor, Pathology and Laboratory Medicine, Perelman School of Medicine

Oncology

Carl June works in the field of Oncology. He attended Baylor College of Medicine. He has 1 awards "Elected Member". Carl June, MD is also published. He has 44 publications published. The lastest publication: "Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.'

Publications

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• Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections.
• Infusion of CD3/CD28 co-stimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment.
• Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.
• Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile and clinical effect.
• NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.
• Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma.
• CD33 Specific Chimeric Antigen Receptor T Cells Exhibit Potent Preclinical Activity against Human Acute Myeloid Leukemia.
• Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells.
• Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies.
• Nature of Tumor Control by Permanently and Transiently Modified GD2 Chimeric Antigen Receptor T Cells in Xenograft Models of Neuroblastoma.
• Mesothelin expression is associated with poor outcomes in breast cancer.
• T-cell immunotherapy: looking forward.
• Toward synthetic biology with engineered T cells: a long journey just begun.
• ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells.
• Multifactorial T cell Hypofunction That is Reversible Can Limit the Efficacy of Chimeric Antibody Receptor-transduced Human T cells in Solid Tumors.
• CARTs on the road for myeloma.
• Engineered T cells for cancer therapy.
• Efficacy against human acute myeloid leukemia and myeloablation of normal hematopoiesis in a mouse model using chimeric antigen receptor-modified T cells.
• Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.
• Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autolo...
• Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity.
• Antibody modified T cells: CARs take the front seat for hematologic malignancies.
• Mesothelin-specific Chimeric Antigen Receptor mRNA-Engineered T cells Induce Anti-Tumor Activity in Solid Malignancies.
• Adoptive Immunotherapy for Cancer or Viruses.
• Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy.
• Engineering T cells for cancer: our synthetic future.
• Chimeric Antigen Receptor Therapy for Cancer.
• Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.
• Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer.
• Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
• Regimen-Specific Effects of RNA-Modified Chimeric Antigen Receptor T Cells in Mice with Advanced Leukemia.
• T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.
• Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology.
• Perspective: assembly line immunotherapy.
• Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation.
• A Pilot Study of Prophylactic Ex Vivo Co-Stimulated Donor Leukocyte Infusions After Reduced Intensity Conditioned Allogeneic Stem Cell Transplantation.
• Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.
• Zoom zoom: racing CARs for multiple myeloma.
• Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer.
• Efficient Clinical Scale Gene Modification via Zinc Finger Nuclease Targeted Disruption of the HIV Co-Receptor CCR5.
• Enhanced function of redirected human T cells expressing linker for activation of T-cells that is resistant to ubiquitylation.
• Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long anti-sense to HIV.
• T-cell therapy at the threshold.

Schools

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• Baylor University

• Nat39l Naval Med Center

• University Wa Med Center

Doctors Specialties

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• Medical Oncology
• Oncology

Accepted Insurances

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• Blue Card PPO
• Cigna HMO
• Cigna PPO
• Great West Healthcare-Cigna PPO
• Open Access Plus
• Coventry Health America PPO
• Coventry Health Care of Delaware PPO
• First Health (Coventry Health Care) PPO
• Community Blue PPO
• Choice Care PPO
• MultiPlan PPO
• Freedom Plan
• Choice Plus POS
• Navigate HMO
• Navigate POS
• Options PPO
• Oxford Liberty

Awards

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• Elected Member

Education

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• University of Washington
• National Capital Consortium
• Baylor College of Medicine

Hospital

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• Hospital of the University of Pennsylvania

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