Professor, Medicine, University of Alabama School of Medicine

Gastroenterology

Dr. Charles O. Elson III practices Gastroenterology. He attended Washington University School of Medicine in St. Louis. Dr. Charles O. Elson III has written publications. He has 52 publications published with PubMed. The lastest paper is: 'Human seroreactivity to gut microbiota antigens.' He accepts Medicare payments and is listed with Medicare.gov.

Publications

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• Human seroreactivity to gut microbiota antigens.
• Interleukin (IL)-21 promotes Intestinal IgA response to microbiota.
• TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression.
• TLR4 regulates IFN-γ and IL-17 production by both thymic and induced Foxp3+ Tregs during Intestinal inflammation.
• Microbiota activation and regulation of innate and adaptive immunity.
• Downregulation of MicroRNA-107 in Intestinal CD11c,(+) myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression.
• Basil isaac hirschowitz, MD.
• ERK mitogen-activated protein kinase differentially regulates Th17- and Treg-cell development and contributes to the pathogenesis of colitis.
• Th17 cells upregulate polymeric Ig receptor and Intestinal IgA and contribute to Intestinal homeostasis.
• Host-microbiota interactions in inflammatory bowel Disease.
• Regulation of Toll-like Receptor 5 Gene Expression and Function on Mucosal Dendritic Cells.
• Microbiota Downregulates Dendritic Cell Expression of miR-10a, Which Targets IL-12/IL-23p40.
• Th17 Cells Induce Colitis and Promote Th1 Cell Responses through IL-17 Induction of Innate IL-12 and IL-23 Production.
• Experimental inflammatory bowel Disease: insights into the host-microbiota dialog.
• Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis.
• Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid.
• Microbiota: Dual-faceted player in experimental colitis.
• Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis.
• A dominant, coordinated T regulatory cell-IgA response to the Intestinal microbiota.
• TGF-beta promotes Th17 cell development through inhibition of SOCS3.
• Late developmental plasticity in the T helper 17 lineage.
• Linkage of Crohn's Disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kappaB activation.
• Enhanced CBir1-specific innate and adaptive immune responses in Crohn's Disease.
• Peyer's patches as the inductive site for IgA responses.
• Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia.
• Perspectives on mucosal vaccines: is mucosal tolerance a barrier?
• Isolation of flagellated bacteria implicated in Crohn's Disease.
• A novel role for defensins in Intestinal homeostasis: regulation of IL-1beta secretion.
• Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice.
• Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice.
• Anti-flagellin (CBir1) phenotypic and genetic Crohn's Disease associations.
• CCFA microbial-host interactions workshop: highlights and key observations.
• Molecular approaches to the role of the microbiota in inflammatory bowel Disease.
• From cheese to pharma: a designer probiotic for IBD.
• Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota.
• Alterations of T lymphocytes in inflammatory bowel Diseases.
• Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens.
• Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's Disease.
• Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function.
• Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells.
• Oral tolerance in humans: failure to suppress an existing immune response by oral antigen administration.
• Refined histopathologic scoring System improves power to detect colitis QTL in mice.
• New developments in experimental models of inflammatory bowel Disease.
• Bacterial flagellin is a dominant antigen in Crohn Disease.
• Gene disruption and immunity in experimental colitis.
• Regulation of gene expression in inflammatory bowel Disease and correlation with IBD drugs: screening by DNA microarrays.
• Challenges in IBD Research: updating the scientific agendas.
• Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora.
• Genes, microbes, and T cells--new therapeutic targets in Crohn's Disease.
• T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis.
• Understanding immune-microbial homeostasis in intestine.

Schools

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• Washington University St Louis

• Cornell Affil Hosps

• University Chicago Hosps

Procedures Preformed

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• Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
• Endoscopy (Esophagus, Stomach, Small Intestine)
• ERCP (Endoscopic Retrograde Cholangiopancreatography)

Conditions Treated

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• Abdominal Pain
• Anemia
• Barrett's Esophagus
• Benign Neoplasm of the Digestive System
• View All

Doctors Specialties

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• Gastroenterology

Accepted Insurances

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Education

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• University of Chicago
• New York Presbyterian Hospital - Cornell Campus
• Washington University School of Medicine in St. Louis

Hospital

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• University of Alabama Hospital
• Birmingham Veterans Affairs Medical Center

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