Professor, Pediatrics, University of Minnesota Medical School
Pediatrics
Dr. Chester B. Whitley, MD
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Chester Whitley is an expert in the field of Pediatrics. He graduated from University of Minnesota Medical School. University of Minnesota Medical School is ranked 40 in research and 10 in primary care medicine He over the years received 1 awards: "CMS Meaningful Use Stage 1 Certification". Dr. Chester B. Whitley is a published doctor. He published 100 publications, including: 'Mobilization and transduction of peripheral blood progenitor cells in patients with mucopolysaccharidosis I.'
Publications
- A Prospective Natural History Study of Mucopolysaccharidosis Type IIIA.
- The Neurobehavioral Phenotype in Mucopolysaccharidosis Type IIIB: an Exploratory Study.
- Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction.
- Elevated TNF-α is associated with pain and physical disability in mucopolysaccharidosis types I, II, and VI.
- Quantifying behaviors of children with Sanfilippo syndrome: The Sanfilippo Behavior Rating Scale.
- Biomarkers of central nervous system inflammation in infantile and juvenile gangliosidoses.
- Gene therapy for neurologic manifestations of mucopolysaccharidoses.
- Cognitive, medical, and neuroimaging characteristics of attenuated mucopolysaccharidosis type II.
- Phenylketonuria Scientific Review Conference: State of the science and future research needs.
- Acquired Autistic Behaviors in Children with Mucopolysaccharidosis Type IIIA.
- Unexpected coronary artery findings in mucopolysaccharidosis. Report of four cases and literature review.
- Neurocognitive and neuropsychiatric phenotypes associated with the mutation L238Q of the α-L-iduronidase gene in Hurler-Scheie syndrome.
- Effect of recombinant human growth hormone on changes in height, bone mineral density, and body composition over 1-2years in children with Hurler or Hunter syndrome.
- Standardization of α-L-iduronidase enzyme assay with Michaelis-Menten kinetics.
- Methods of Neurodevelopmental Assessment in Children with Neurodegenerative Disease: Sanfilippo Syndrome.
- High-dose enzyme replacement therapy in murine Hurler syndrome.
- Mucopolysaccharidosis Type IIIA presents as a variant of Klüver-Bucy syndrome.
- Low Bone Mineral Content and Challenges in Interpretation of Dual-Energy X-Ray Absorptiometry in Children With Mucopolysaccharidosis Types I, II, and VI.
- Cardiac Ultrasound Findings in Infants with Severe (Hurler Phenotype) Untreated Mucopolysaccharidosis (MPS) Type I.
- Lysosomal Disease Network's WORLD Symposium™ 2013.
- Enzyme Replacement is Associated with Better Cognitive Outcomes after Transplant in Hurler Syndrome.
- Increased longevity and metabolic correction following syngeneic BMT in a murine model of mucopolysaccharidosis type I.
- An exploratory study of brain function and structure in mucopolysaccharidosis type I: Long term observations following hematopoietic cell transplantation (HCT).
- Lysosomal Disease Network's WORLD Symposium??? 2012.
- Source document verification in the Mucopolysaccharidosis Type I Registry.
- START, a double blind, placebo-controlled pharmacogenetic test of responsiveness to sapropterin dihydrochloride in phenylketonuria patients.
- Direct gene transfer to the CNS prevents emergence of neurologic disease in a murine model of mucopolysaccharidosis type I.
- Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI): a single dose of galsulfase further reduces urine glycosaminoglycans after hematopoietic stem cell transplanta...
- Enzyme replacement therapy for mucopolysaccharidosis VI: Growth and pubertal development in patients treated with recombinant human N-acetylgalactosamine 4-sulfatase.
- Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system.
- Lysosomal Disease Network's "WORLD Symposium 2009". Introduction.
- Cardiac findings after enzyme replacement therapy for mucopolysaccharidosis type I.
- Safety and efficacy of enzyme replacement therapy in combination with hematopoietic stem cell transplantation in Hurler syndrome.
- Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-idu...
- Enzyme replacement therapy in mucopolysaccharidosis VI (Maroteaux-Lamy syndrome).
- Prospective diagnosis of 2-methylbutyryl-CoA dehydrogenase deficiency in the Hmong population by newborn screening using tandem mass spectrometry.
- Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bon...
- Urinary glycosaminoglycan excretion quantified by an automated semimicro method in specimens conveniently transported from around the globe.
- Mosaicism of podocyte involvement is related to podocyte injury in females with fabry disease.
- Effect of oral magnesium supplementation on selected cardiovascular risk factors in non-insulin-dependent diabetics.
- Adams-Oliver syndrome revisited.
- Direct hyperbilirubinemia and hepatic fibrosis: a new presentation of Jeune syndrome (asphyxiating thoracic dystrophy).
- Amiodarone phenocopy of Fabry's keratopathy.
- Warburg syndrome: lethal neurodysplasia with autosomal recessive inheritance.
- A new mtDNA mutation in the tRNA(Leu(UUR)) gene associated with maternally inherited cardiomyopathy.
- Persistent succinylacetone excretion after liver transplantation in a patient with hereditary tyrosinaemia type I.
- Light and electron microscopic features of the liver in mucopolysaccharidosis.
- In vivo chloroquine-induced inhibition of insulin degradation in a diabetic patient with severe insulin resistance.
- Busulfan disposition in children.
- Clinical and biochemical heterogeneity in females of a large pedigree with ornithine transcarbamylase deficiency due to the R141Q mutation.
- Comparison of enzymatic activity with evidence of engraftment in patients with inborn errors of metabolism receiving allogeneic marrow transplantation.
- Genotype-phenotype correspondence in Sanfilippo syndrome type B.
- Lysinuric protein intolerance masquerading as celiac disease: a case report.
- Heterozygosity for the "DN allele" (G533-greater than A) of the beta-hexosaminidase alpha subunit gene identified by direct DNA sequencing in a family with the B1 vari...
- A nonpathologic allele (IW) for low alpha-L-iduronidase enzyme activity vis-a-vis prenatal diagnosis of Hurler syndrome.
- Diagnostic test for mucopolysaccharidosis. I. Direct method for quantifying excessive urinary glycosaminoglycan excretion.
- Diagnostic test for mucopolysaccharidosis. II. Rapid quantification of glycosaminoglycan in urine samples collected on a paper matrix.
- Growth and endocrine function in patients with Hurler syndrome after hematopoietic stem cell transplantation.
- Ocular changes in the mucopolysaccharidoses after bone marrow transplantation. A preliminary report.
- Canine heparan sulfate sulfamidase and the molecular pathology underlying Sanfilippo syndrome type A in Dachshunds.
- Bone marrow transplantation for Hurler syndrome: assessment of metabolic correction.
- Radiological case of the month. Coarctation of the aorta in Hurler syndrome.
- Mutation R468W of the iduronate-2-sulfatase gene in mild Hunter syndrome (mucopolysaccharidosis type II) confirmed by in vitro mutagenesis and expression.
- Assessment of iduronate-2-sulfatase mRNA expression in Hunter syndrome (mucopolysaccharidosis type II).
- Retroviral transduction of peripheral blood leukocytes in a hollow-fiber bioreactor.
- Syringomyelia in mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome): imaging findings following bone marrow transplantation.
- Metabolic correction and cross-correction of mucopolysaccharidosis type II (Hunter syndrome) by retroviral-mediated gene transfer and expression of human iduronate-2-s...
- Resolution of obstructive sleep apnea in Hurler syndrome after bone marrow transplantation.
- Pathology of the liver in mucopolysaccharidosis: light and electron microscopic assessment before and after bone marrow transplantation.
- Molecular basis of mucopolysaccharidosis type IIIB in emu (Dromaius novaehollandiae): an avian model of Sanfilippo syndrome type B.
- Long-term outcome of Hurler syndrome following bone marrow transplantation.
- Real-time quantitative polymerase chain reaction to assess gene transfer.
- Molecular genetic defect underlying alpha-L-iduronidase pseudodeficiency.
- Combination of enzyme replacement and hematopoietic stem cell transplantation as therapy for Hurler syndrome.
- Retroviral vector design studies toward hematopoietic stem cell gene therapy for mucopolysaccharidosis type I.
- Caveat to genotype-phenotype correlation in mucopolysaccharidosis type II: discordant clinical severity of R468W and R468Q mutations of the iduronate-2-sulfatase gene.
- Retroviral transduction and expansion of peripheral blood lymphocytes for the treatment of mucopolysaccharidosis type II, Hunter's syndrome.
- Mobilization and transduction of peripheral blood progenitor cells in patients with mucopolysaccharidosis I.
- Molecular diagnosis of mucopolysaccharidosis type II (Hunter syndrome) by automated sequencing and computer-assisted interpretation: toward mutation mapping of the idu...
- Evaluation of coronary artery disease in the Hurler syndrome by angiography.
- Enzymatic correction and cross-correction of mucopolysaccharidosis type I fibroblasts by adeno-associated virus-mediated transduction of the alpha-L-iduronidase gene.
- Preclinical studies of lymphocyte gene therapy for mild Hunter syndrome (mucopolysaccharidosis type II).
- "Supercharged Cells" for delivery of recombinant human iduronate-2-sulfatase.
- Closed hollow-fiber bioreactor: a new approach to retroviral vector production.
- Combined ultrafiltration-transduction in a hollow-fiber bioreactor facilitates retrovirus-mediated gene transfer into peripheral blood lymphocytes from patients with m...
- Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease.
- The long-term outcomes of presymptomatic infants transplanted for Krabbe disease: report of the workshop held on July 11 and 12, 2008, Holiday Valley, New York.
- Pre-stem cell transplantation enzyme replacement therapy in Hurler syndrome does not lead to significant antibody formation or delayed recovery of the endogenous enzym...
- Craniofacial abnormalities in a murine knock-out model of mucopolysaccharidosis I H: a computed tomography and anatomic study.
- Construction of a high efficiency retroviral vector for gene therapy of Hunter''s syndrome.
- A preliminary report on dopamine system reactivity in PKU: acute effects of haloperidol on neuropsychological, physiological, and neuroendocrine functions.
- Excision of Sleeping Beauty transposons: parameters and applications to gene therapy.
- Prolonged expression of a lysosomal enzyme in mouse liver after Sleeping Beauty transposon-mediated gene delivery: implications for non-viral gene therapy of mucopolys...
- Agalsidase-beta therapy for advanced Fabry disease: a randomized trial.
- Age-related functional and histopathological changes of the ear in the MPS I mouse.
- Efficacy of sapropterin dihydrochloride (tetrahydrobiopterin, 6R-BH4) for reduction of phenylalanine concentration in patients with phenylketonuria: a phase III random...
- Improved gene transfer and normalized enzyme levels in primitive hematopoietic progenitors from patients with mucopolysaccharidosis type I using a bioreactor.
- Efficacy of sapropterin dihydrochloride in increasing phenylalanine tolerance in children with phenylketonuria: a phase III, randomized, double-blind, placebo-controll...
- Enzyme replacement therapy for mucopolysaccharidosis VI: evaluation of long-term pulmonary function in patients treated with recombinant human N-acetylgalactosamine 4-...
Schools
University of Mn Med Sch
University Of Minnesota
Doctors Specialties
- Clinical Biochemical Genetics
- Clinical Genetics
- Pediatrics
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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University of Minnesota at Fairview -
University of Minnesota Medical School
Hospital
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University of Minnesota Medical Center, Fairview
Drug Facts
| NPI NUMBER | 1588735005 | |
| NPPES Provider LastName | WHITLEY | |
| NPPES Provider FirstName | CHESTER | |
| NPPES Provider ZIPCode | 55455 | |
| NPPES Provider State | MN | |
| Specialty Description | Pediatric Medicine | |
| Total Claim Count | 107.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
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Medicare Facts
| National Provider Identifier [NPI] | 1588735005 |
| Last Name Of The Provider | WHITLEY |
| First Name Of The Provider | CHESTER |
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