Professor, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Southwestern Medical School
Cardiology
Dr. Craig R. Malloy, MD
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Doctor Craig R. Malloy, MD works in the field of Cardiology. He went to University of California San Francisco School of Medicine. University of California San Francisco School of Medicine is a one of the best medicals schools. University of California San Francisco School of Medicine is ranked 3/3 in Research/PrimaryCare. Craig Malloy has written publications. He has 101 publications published with PubMed. The lastest publication is: 'Metabolic Heterogeneity in Human Lung Tumors.'
Publications
- Metabolic Heterogeneity in Human Lung Tumors.
- Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.
- (31) P-MRS of healthy human brain: ATP synthesis, metabolite concentrations, pH, and T1 relaxation times.
- Production of hyperpolarized (13)CO2 from [1-(13)C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production.
- Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.
- Amplification of the effects of magnetization exchange by (31) P band inversion for measuring adenosine triphosphate synthesis rates in human skeletal muscle.
- Real-time Detection of Hepatic Gluconeogenic and Glycogenolytic States Using Hyperpolarized [2-13C]Dihydroxyacetone.
- Interaction between the Pentose Phosphate Pathway and Gluconeogenesis from Glycerol in the Liver.
- MED13-dependent signaling from the Heart confers leanness by enhancing metabolism in adipose tissue and liver.
- Propionate stimulates pyruvate oxidation in the presence of acetate.
- Influence of Liver Triglycerides on Suppression of Glucose Production by Insulin in Men.
- The Ratio of Acetate-to-Glucose Oxidation in Astrocytes from a Single (13) C NMR Spectrum of Cerebral Cortex.
- Hyperpolarized (13) C NMR detects rapid drug-induced changes in cardiac metabolism.
- Exchange kinetics by inversion transfer: Integrated analysis of the phosphorus metabolite kinetic exchanges in resting human skeletal muscle at 7 T.
- Quadrature transmit coil for breast imaging at 7 tesla using forced current excitation for improved homogeneity.
- Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP.
- Modeling of brain metabolism and pyruvate compartmentation using (13)C NMR in vivo: caution required.
- A comparative study of short- and long-TE (1) H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors.
- Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain.
- Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent.
- Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS.
- Noninvasive monitoring of lactate dynamics in human forearm muscle after exhaustive exercise by (1) H-magnetic resonance spectroscopy at 7 tesla.
- Hepatic glucose production pathways after three days of a high-fat diet.
- Cortical metabolism in pyruvate dehydrogenase deficiency revealed by ex vivo multiplet (13)C NMR of the adult mouse brain.
- Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.
- Impact of Gd(3+) on DNP of 1-(13)CPyruvate Doped with Trityl OX063, BDPA, or 4-Oxo-TEMPO.
- Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized (13) C NMR.
- Metabolism of U-(13) Cglucose in human brain tumors in vivo.
- Reply to: Intramyocellular lipids vs. intramyocellular triglycerides.
- Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance.
- Transfer of hyperpolarization from long T(1) storage nuclei to short T(1) neighbors using FLOPSY-8.
- High-resolution detection of (13)C multiplets from the conscious mouse brain by ex vivo NMR spectroscopy.
- DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.
- In vivo determination of human breast fat composition by (1) H magnetic resonance spectroscopy at 7 T.
- Could (13) C MRI assist clinical decision-making for patients with heart Disease?
- Measurement of glycine in the human brain in vivo by (1) H-MRS at 3 T: application in brain tumors.
- 1H MRS of intramyocellular lipids in soleus muscle at 7 T: spectral simplification by using long echo times without water suppression.
- Competition of pyruvate with physiological substrates for oxidation by the Heart: implications for studies with hyperpolarized [1-13C]pyruvate.
- Hyperpolarized 89Y complexes as pH sensitive NMR probes.
- Responsive MRI agents for sensing metabolism in vivo.
- Evidence for reverse flux through pyruvate kinase in skeletal muscle.
- Orientation of lipid strands in the extracellular compartment of muscle: effect on quantitation of intramyocellular lipids.
- Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-.
- Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.
- Imaging the tissue distribution of glucose in livers using a PARACEST sensor.
- Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla.
- Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR.
- Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formate.
- Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance.
- Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.
- MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST).
- Role of excess glycogenolysis in fasting hyperglycemia among pre-diabetic and diabetic Zucker (fa/fa) rats.
- Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-def...
- The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism.
- MRI thermometry based on PARACEST agents.
- Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting.
- Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance.
- Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose.
- Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the Heart.
- Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.
- A (13)C isotopomer kinetic analysis of cardiac metabolism: influence of altered cytosolic redox and [Ca(2+)](o).
- Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative.
- Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy.
- Analytical solutions for (13)C isotopomer analysis of complex metabolic conditions: substrate oxidation, multiple pyruvate cycles, and gluconeogenesis.
- Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra.
- Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis.
- Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry.
- Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.
- Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine.
- Effects of hypothermia on myocardial substrate selection.
- 13C isotopomer analysis of glutamate by tandem mass spectrometry.
- Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.
- Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR.
- Energetics and metabolism in the failing Heart: important but poorly understood.
- Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse Heart as measured by NMR spectroscopy.
- Compartmentation of glycolysis and glycogenolysis in the perfused rat Heart.
- Measuring in-vivo metabolism using nuclear magnetic resonance.
- Hepatic gluconeogenesis and Krebs cycle fluxes in a CCl4 model of Acute liver failure.
- Tm(DOTP)5-: a 23Na+ shift agent for perfused rat Hearts.
- Influence of global ischemia on intracellular sodium in the perfused rat Heart.
- 13C isotopomer analysis of glutamate by J-resolved heteronuclear single quantum coherence spectroscopy.
- Correlation of cerebral metabolites with clinical outcome among patients with severe Congestive heart failure.
- TCA cycle kinetics in the rat Heart by analysis of (13)C isotopomers using indirect (1)H.
- An integrated (2)H and (13)C NMR study of gluconeogenesis and TCA cycle flux in humans.
- NMR indirect detection of glutamate to measure citric acid cycle flux in the isolated perfused mouse Heart.
- A noninvasive assessment of myocardial oxygen tension: 19F NMR spectroscopy of sequestered perfluorocarbon emulsion.
- Alterations in substrate utilization in the reperfused myocardium: a direct analysis by 13C NMR.
- Respiratory control and substrate effects in the working rat Heart.
- Determination of chloride potential in perfused rat Hearts by nuclear magnetic resonance spectroscopy.
- Predicting functional recovery from ischemia in the rat myocardium.
- Regulatory consequences of organization of citric acid cycle enzymes.
- Direct observation of lactate and alanine by proton double quantum spectroscopy in rat Hearts supplied with [3-13C]pyruvate.
- In vivo Na-23 MR imaging and spectroscopy of rat brain during TmDOTP5- infusion.
- Effects of bucindolol on neurohormonal activation in Congestive heart failure.
- Influence of cardiac pacing on intracellular sodium in the isolated perfused rat Heart.
- Is there tight channelling in the tricarboxylic acid cycle metabolon?
- Effect of beta-adrenergic blockade on myocardial function and energetics in Congestive heart failure. Improvements in hemodynamic, contractile, and diastolic performan...
- Analysis of tricarboxylic acid cycle of the Heart using 13C isotope isomers.
- Contribution of exogenous substrates to acetyl coenzyme A: measurement by 13C NMR under non-steady-state conditions.
- NOTPME: a 31P NMR probe for measurement of divalent cations in biological systems.
Schools
University of California At San Francisco
Parkland Memorial Hospital
Brigham Womens Hospital
Oxford University
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Congestive Heart Failure
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Doctors Specialties
- Cardiology
Accepted Insurances
- Cigna
- Mail Handlers Benefit Plan (MHBP)
- Medicare MCR
Education
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Brigham and Women's Hospital -
University of California San Francisco School of Medicine
Hospital
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University of Texas Southwestern Medical Center -
Veterans Affairs North Texas Health Care System
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