Wellcome Professor and Director, Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine
Infectious Disease
Dr. Craig W. Hendrix, MD
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Craig Hendrix works in the field of Infectious Disease. He went to medical school at Georgetown University School of Medicine. Georgetown University School of Medicine is ranked 49 in research and 84 in primary care medicine He received 13 awards: "David M. Levine Faculty Mentoring Award (Department of Medicine)", "Excellence in Teaching Award", "Student Marshal", "Outstanding Pharmacology Professor (Basic Sciences)", "Meritorious Service Medal, First Oak Leaf Cluster", "Faculty Development Award", "Meritorious Service Medal", "Department of Medicine Award for Outstanding Academic Performance", "Cahill Award for Academic Excellence in Surgery", "Magna Cum Laude", "Alpha Omega Alpha Honor Medical Society", "Air Force Commendation Medal" and "Distinguished Military Graduate". Craig Hendrix is a published doctor and has 100 publications published. The lastest was: 'Size and duration of zidovudine benefit in 1003 HIV-infected patients: U.S. Army, Navy, and Air Force natural history data. Military Medical Consortium for Applied Ret...'
Publications
- Plasma and intracellular ribavirin concentrations are not significantly altered by abacavir in hepatitis C virus-infected patients.
- Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women.
- Impact of Sex on the Pharmacokinetics and Pharmacodynamics of 1% Tenofovir Gel.
- Pharmacological Measures of Treatment Adherence and Risk of HIV Infection in the VOICE Study.
- Simultaneous Evaluation of Safety, Acceptability, Pericoital Kinetics, and Ex Vivo Pharmacodynamics Comparing Four Rectal Microbicide Vehicle Candidates.
- Phase 1 clinical trials of DAS181, an inhaled sialidase, in healthy adults.
- A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with S...
- A Pilot Study Measuring the Distribution and Permeability of a Vaginal HIV Microbicide Gel Vehicle Using Magnetic Resonance Imaging, Single Photon Emission Computed To...
- Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner.
- Levels of Genital Tract Defensins and Cytokines Differ between HIV-Uninfected US and African Women.
- Enema ion compositions for enhancing colorectal drug delivery.
- Phase 1 Safety, Pharmacokinetics, and Pharmacodynamics of Dapivirine and Maraviroc Vaginal Rings: a Double-Blind Randomized Trial.
- Tenofovir-based preexposure prophylaxis for HIV infection among African women.
- CYP3A5 genotype impacts maraviroc concentrations in healthy volunteers.
- Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study.
- Comparing the Novel Method of Assessing PrEP Adherence/Exposure using Hair Samples to other Pharmacologic and Traditional Measures.
- Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-...
- High Medication Adherence During Periconception Periods Among HIV-1-Uninfected Women Participating in a Clinical Trial of Antiretroviral Pre-exposure Prophylaxis.
- Renal Function of Participants in the Bangkok Tenofovir Study-Thailand, 2005-2012.
- Daily Oral Tenofovir and Emtricitabine-Tenofovir Preexposure Prophylaxis Reduces Herpes Simplex Virus Type 2 Acquisition Among Heterosexual HIV-1-Uninfected Men and W...
- Safety and Pharmacokinetics of XOMA 3AB, a Novel Mixture of Three Monoclonal Antibodies against Botulinum Toxin A.
- HIV Protective Efficacy and Correlates of Tenofovir Blood Concentrations in a Clinical Trial of PrEP for HIV Prevention.
- Risk behaviors and risk factors for HIV infection among participants in the Bangkok tenofovir study, an HIV pre-exposure prophylaxis trial among people who inject drugs.
- Efficacy of preexposure prophylaxis for HIV-1 prevention among high-risk heterosexuals: subgroup analyses from a randomized trial.
- Preliminary Study of Quinine Pharmacokinetics in Pregnant Women with Malaria-HIV Co-Infection.
- Antiviral Activity of Genital Tract Secretions following Oral or Topical Tenofovir Pre-exposure Prophylaxis for HIV-1.
- Estimation of tenofovir's population pharmacokinetic parameters without reliable dosing histories and application to tracing dosing history using simulation strategies.
- The development and validation of an UHPLC-MS/MS method for the rapid quantification of the antiretroviral agent dapivirine in human plasma.
- Exploring Concentration Response in HIV Pre-Exposure Prophylaxis to Optimize Clinical Care and Trial Design.
- A Randomized Male Tolerance Study of Dapivirine Gel Following Multiple Topical Penile Exposures (MTN 012/IPM 010).
- Dissimilarities in the Metabolism of Antiretroviral Drugs used in HIV Pre-exposure Prophylaxis in Colon and Vagina Tissues.
- Protein-free efavirenz concentrations in cerebrospinal fluid and blood plasma are equivalent: applying the law of mass action to predict protein-free drug concentration.
- Undisclosed antiretroviral drug use in a multi-national clinical trial (HPTN 052).
- Iso-osmolar enemas demonstrate preferential gastrointestinal distribution, safety, and acceptability compared with hyper- and hypo-osmolar enemas as a potential delive...
- Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlle...
- Quantitative assessment of altered rectal mucosal permeability due to rectally applied nonoxynol-9, biopsy, and simulated intercourse.
- Increasing Extracellular Protein Concentration Reduces Intracellular Antiretroviral Drug Concentration and Antiviral Effect.
- Single Dose Pharmacokinetics of Oral Tenofovir in Plasma, Peripheral Blood Mononuclear Cells, Colonic and Vaginal Tissue.
- MTN-001: Randomized Pharmacokinetic Cross-Over Study Comparing Tenofovir Vaginal Gel and Oral Tablets in Vaginal Tissue and Other Compartments.
- Adherence and Acceptability in MTN 001: A Randomized Cross-Over Trial of Daily Oral and Topical Tenofovir for HIV Prevention in Women.
- Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid.
- Biphasic elimination of tenofovir diphosphate and nonlinear pharmacokinetics of zidovudine triphosphate in a microdosing study.
- Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc.
- Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging.
- RMP-02/MTN-006: A Phase 1 Rectal Safety, Acceptability, Pharmacokinetic, and Pharmacodynamic Study of Tenofovir 1% Gel Compared with Oral Tenofovir Disoproxil Fumarate.
- The clinical pharmacology of antiretrovirals for HIV prevention.
- Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana.
- Stavudine concentrations in women receiving postpartum antiretroviral treatment and their breastfeeding infants.
- Effects of ritonavir-boosted lopinavir on the pharmacokinetics of quinine.
- Pharmacokinetics and placental transfer of single-dose tenofovir 1% vaginal gel in term pregnancy.
- NONLINEAR TUBE-FITTING FOR THE ANALYSIS OF ANATOMICAL AND FUNCTIONAL STRUCTURES.
- Distribution of Cell-free and Cell-associated HIV surrogates in the Colon Following Simulated Receptive Anal Intercourse in Men who Have Sex with Men.
- Prevention of HIV-1 infection with early antiretroviral therapy.
- The male genital tract is not a pharmacological sanctuary from efavirenz.
- Assessing bioequivalence of generic antiepilepsy drugs.
- Clonidine clearance matures rapidly during the early postnatal period: a population pharmacokinetic analysis in newborns with neonatal abstinence syndrome.
- Implications of HIV PrEP trials results.
- Performance of swabs, lavage, and diluents to quantify biomarkers of female genital tract soluble mucosal mediators.
- A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.
- Clinical evaluation of microbicide formulations.
- Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial.
- Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites.
- The epidemiology of Candida colonization and invasive candidiasis in a surgical intensive care unit where fluconazole prophylaxis is utilized: follow-up to a randomize...
- Topical microbicides to prevent HIV: clinical drug development challenges.
- A Case Study in Pharmacologic Colon Imaging Using Principal Curves in Single Photon Emission Computed Tomography.
- Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir.
- Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with fosamprenavir-ritonavir in opioid-dependent subjects.
- Effect of semen sampling frequency on seminal antiretroviral drug concentration.
- Effect of low-dose ritonavir on the pharmacokinetics of the CXCR4 antagonist AMD070 in healthy volunteers.
- Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers.
- Male genital tract pharmacology: developments in quantitative methods to better understand a complex peripheral compartment.
- Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin.
- Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates.
- Food affects Zidovudine concentration independent of effects on gastrointestinal absorption.
- Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects.
- Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission.
- Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive method.
- The association between anatomic site of Candida colonization, invasive candidiasis, and mortality in critically ill surgical patients.
- Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women.
- Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with amprenavir in opioid-dependent subjects.
- Impact of fluconazole prophylaxis on cortisol levels in critically ill surgical patients.
- The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone.
- Risk of colonization of central venous catheters: catheters for total parenteral nutrition vs other catheters.
- Enteral fluconazole population pharmacokinetics in patients in the surgical intensive care unit.
- A phase I/II study of nevirapine for pre-exposure prophylaxis of HIV-1 transmission in uninfected subjects at high risk.
- The diagnostic value of fungal surveillance cultures in critically ill patients.
- Vancomycin-sensitive and vancomycin-resistant enterococcal infections in the ICU: attributable costs and outcomes.
- Enteral fluconazole is well absorbed in critically ill surgical patients.
- Double-blind placebo-controlled trial of fluconazole to prevent candidal infections in critically ill surgical patients.
- Surveillance strategies and impact of vancomycin-resistant enterococcal colonization and infection in critically ill patients.
- Increased resource use associated with catheter-related bloodstream infection in the surgical intensive care unit.
- Military HIV-prevention education: the use of evaluation to inform the evolution of policy.
- Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers.
- International military human immunodeficiency virus/acquired immunodeficiency syndrome policies and programs: strengths and limitations in current practice.
- Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists.
- Escalating multiple-dose safety and tolerance study of oral WR 6026 in HIV-infected subjects: AIDS clinical trials group 173.
- The effects of rifampin and rifabutin on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive.
- Size and duration of zidovudine benefit in 1003 HIV-infected patients: U.S. Army, Navy, and Air Force natural history data. Military Medical Consortium for Applied Ret...
- A phase 1 randomized placebo-controlled safety and pharmacokinetic trial of a tenofovir disoproxil fumarate vaginal ring.
Schools
Georgetown University
Johns Hopkins Hospital
Johns Hopkins University
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- MultiPlan PPO
Awards
- David M. Levine Faculty Mentoring Award (Department of Medicine)
- Excellence in Teaching Award
- Student Marshal
- Outstanding Pharmacology Professor (Basic Sciences)
- Meritorious Service Medal, First Oak Leaf Cluster
- Faculty Development Award
- Meritorious Service Medal
- Department of Medicine Award for Outstanding Academic Performance
- Cahill Award for Academic Excellence in Surgery
- Magna Cum Laude
- Alpha Omega Alpha Honor Medical Society
- Air Force Commendation Medal
- Distinguished Military Graduate
Education
-
Johns Hopkins University -
Georgetown University School of Medicine
Hospital
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Johns Hopkins Hospital
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