Professor of Medicine
Internal Medicine
Dr. Curt R. Freed, MD
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Curt Freed practices Internal Medicine. He attended Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1 in research and 12 in primary care medicine He received 1 awards: "Elected Member". Dr. Curt R. Freed is also a published doctor. He has 100 publication published. The most recent publication is: Efficacy of grafted immortalized dopamine neurons in an animal model of parkinsonism: a review.
Publications
- Biomimetic poly(serinol hexamethylene urea) for promotion of neurite outgrowth and guidance.
- Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus infection.
- The trained circling rat: a model for inducing unilateral caudate dopamine metabolism.
- Regional brain dopamine metabolism: a marker for the speed, direction, and posture of moving animals.
- In vivo electrochemical detection of extraneuronal 5-hydroxyindole acetic acid and norepinephrine in the dorsal raphe nucleus of urethane-anesthetized rats.
- Normal rats trained to circle show asymmetric caudate dopamine release.
- Factors affecting in vivo electrochemistry: electrode-tissue interaction and the ascorbate amplification effect.
- Brain tissue and plasma assay of L-DOPA and alpha-methyldopa metabolites by high performance liquid chromatography with electrochemical detection.
- Measurement of serotonin turnover rate in rat dorsal raphe nucleus by in vivo electrochemistry.
- Reversal of amphetamine-induced circling preference in trained circling rats.
- Changes in arterial blood pressure lead to baroreceptor-mediated changes in norepinephrine and 5-hydroxyindoleacetic acid in rat nucleus tractus solitarius.
- Catechol and indole metabolism in rostral ventrolateral medulla change synchronously with changing blood pressure.
- Flecainide overdose: is cardiopulmonary support the treatment?
- Ascorbic acid concentration in the lateral hypothalamus is related to plasma osmolality.
- Brain acetaminophen measurement by in vivo dialysis, in vivo electrochemistry and tissue assay: a study of the dialysis technique in the rat.
- Changes in neurotransmitter turnover in locus coeruleus produced by changes in arterial blood pressure.
- Dopamine transporter immunoreactivity in rat brain.
- Mass spectrometric measurement of catecholamine turnover in rat hypothalamus after long-term L-dopa infusion.
- The trained circling rat and in vivo electrochemistry: a behavioral model and a measurement method to study the dynamic role of dopamine in movement.
- Localization of dopamine transporter protein by microscopic histochemistry.
- Asymmetric dopamine and serotonin metabolism in nigrostriatal and limbic structures of the trained circling rat.
- Chemical lonization mass spectrometric measurement of alpha-methyldopa and s-dopa metabolites in rat brain regions.
- Mobilization of storage pool dopamine and late ipsilateral augmentation of striatal dopamine synthesis in the trained circling rat.
- Immunological responses to injury and grafting in the central nervous system of nonhuman primates.
- In vivo dialysis measurements of dopamine and DOPAC in rats trained to turn on a circular treadmill.
- Electrophysiology of ventromedial striatal neurons during movement.
- Plasma osmolality predicts extracellular fluid catechol concentrations in the lateral hypothalamus.
- Drug-induced changes in blood pressure lead to changes in extracellular concentrations of epinephrine, dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid in th...
- Conditioned rotation: a behavioral analysis.
- Production of terminally differentiated neuroblastoma cells in culture.
- Trained and amphetamine-induced circling behavior in lesioned, transplanted rats.
- Age at symptom onset predicts severity of motor impairment and clinical outcome of glutaric acidemia type 1.
- Unilateral activation of caudate tyrosine hydroxylase during voluntary circling behavior.
- Preliminary voice and speech analysis following fetal dopamine transplants in 5 individuals with Parkinson disease.
- Unilateral dopamine depletion causes bilateral deficits in conditioned rotation in rats.
- Does personality change as a result of fetal tissue transplantation in the brain?
- Wire electrodes for chronic single unit recording of dopamine cells in substantia nigra pars compacta of awake rats.
- Segregation of human neural stem cells in the developing primate forebrain.
- Establishment of human embryonic brain cell lines.
- Electrophysiological analysis of dopamine cells from the substantia nigra pars compacta of circling rats.
- Brain contains inhibiting factors specific to the large T-antigen gene.
- Infant mice with glutaric acidaemia type I have increased vulnerability to 3-nitropropionic acid toxicity.
- IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures.
- Lack of a detectable systemic humoral/cellular allogeneic response in human and nonhuman primate recipients of embryonic mesencephalic allografts for the therapy of Pa...
- Placebo surgery in trials of therapy for Parkinson's disease.
- Transplantation of fetal mesencephalic tissue in Parkinson's disease.
- GDNF improves survival and reduces apoptosis in human embryonic dopaminergic neurons in vitro.
- IGF-I and bFGF improve dopamine neuron survival and behavioral outcome in parkinsonian rats receiving cultured human fetal tissue strands.
- Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes.
- Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes.
- Establishment and characterization of immortalized clonal cell lines from fetal rat mesencephalic tissue.
- Implantation of fetal tissue for the management of Parkinson's disease: a technical note.
- Dyskinesia after fetal cell transplantation for parkinsonism: a PET study.
- Insulin-like growth factor binding proteins in fetal rat mesencephalic cultures: regulation by fibroblast growth factor and insulin-like growth factor I.
- Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease.
- Growth factors rescue embryonic dopamine neurons from programmed cell death.
- Inhibition of proliferation and expression of T-antigen in SV40 large T-antigen gene-induced immortalized cells following transplantations.
- Development of fetal neural transplantation as a treatment for Parkinson''s disease.
- Intrastriatal grafting of Cos cells stably expressing human aromatic L-amino acid decarboxylase: neurochemical effects.
- Nerve growth factor-dependence of herpes simplex virus latency in peripheral sympathetic and sensory neurons in vitro.
- Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease.
- Improved drug responsiveness following fetal tissue implant for Parkinson''s disease.
- Cognition following bilateral implants of embryonic dopamine neurons in PD: a double blind study.
- Therapeutic effects of human fetal dopamine cells transplanted in a patient with Parkinson''s disease.
- GDNF reduces apoptosis in dopaminergic neurons in vitro.
- Characterization and transplantation of two neuronal cell lines with dopaminergic properties.
- Embryonic dopamine cell implants as a treatment for the second phase of Parkinson's disease. Replacing failed nerve terminals.
- Conditioned medium from aged monkey fibroblasts stably expressing GDNF and BDNF improves survival of embryonic dopamine neurons in vitro.
- Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
- Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons.
- Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.
- Co-grafts of muscle cells and mesencephalic tissue into hemiparkinsonian rats: behavioral and histochemical effects.
- Somatic cell cloned transgenic bovine neurons for transplantation in parkinsonian rats.
- Efficacy of grafted immortalized dopamine neurons in an animal model of parkinsonism: a review.
- Immortalized dopamine neurons: A model to study neurotoxicity and neuroprotection.
- Neural transplantation of hNT neurons for Huntington's disease.
- Strands of embryonic mesencephalic tissue show greater dopamine neuron survival and better behavioral improvement than cell suspensions after transplantation in parkin...
- Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats.
- Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortal...
- Transplantation of human fetal dopamine cells for Parkinson's disease. Results at 1 year.
- Dopamine cell transplantation for Parkinson's disease: the importance of controlled clinical trials.
- Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease.
- Pallidal neuronal discharge in Parkinson''s disease following intraputamenal fetal mesencephalic allograft.
- Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice.
- Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells.
- Transplantation.
- Noggin enhances dopamine neuron production from human embryonic stem cells and improves behavioral outcome after transplantation into Parkinsonian rats.
- Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease.
- Placebo response in Parkinson''s disease: comparisons among 11 trials covering medical and surgical interventions.
- DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity.
- Nectin-1/HveC Mediates herpes simplex virus type 1 entry into primary human sensory neurons and fibroblasts.
- Characterization of the Bex gene family in humans, mice, and rats.
- Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line.
- Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF.
- Reaction time and movement time after embryonic cell implantation in Parkinson disease.
- Preoperative response to levodopa is the best predictor of transplant outcome.
- Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial.
- Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity.
- The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons.
Schools
Harvard Medical School
La Co Harbor UCLA Med Center
Mass Gen Hospital
Moffitt Hospital University Of Ca
Doctors Specialties
- Clinical Pharmacology
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
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UCSF -
Massachusetts General Hospital -
Harbor - UCLA Medical Center -
Harvard Medical School
Hospital
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University of Colorado Hospital
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