Physician
Hematology
Dr. Cynthia E. Dunbar, MD
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Cynthia Dunbar practices Hematology. She studied medicine at Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1 in research and 12 in primary care medicine She over the years received 1 awards: "Elected Member". Cynthia E. Dunbar, MD is also published. She has 93 publications published. The lastest publication: "Thrombopoietic status of patients on haemodialysis.'
Publications
- Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders.
- Angioedema in patients treated with sirolimus and ACE inhibitor post hematopoietic SCT.
- An AAVS1-targeted Minigene Platform for Correction of iPSCs from All Five Types of Chronic Granulomatous Disease.
- IFN-γ regulates survival and function of tumor-induced CD11b(+) Gr-1(high) myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.
- Path to the Clinic: Assessment of iPSC-Based Cell Therapies In Vivo in a Nonhuman Primate Model.
- Dynamics of HSPC Repopulation in Nonhuman Primates Revealed by a Decade-Long Clonal-Tracking Study.
- Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cells.
- Eltrombopag restores tri-lineage hematopoiesis in refractory severe aplastic anemia which can be sustained on discontinuation of drug.
- Differences in the Phenotype, Cytokine Gene Expression Profiles, and In Vivo Alloreactivity of T Cells Mobilized with Plerixafor Compared with G-CSF.
- Active thrombopoiesis is associated with worse severity and activity of chronic GVHD.
- No Impact of Lentiviral Transduction on Hematopoietic Stem/Progenitor Cell Telomere Length or Gene Expression in the Rhesus Macaque Model.
- Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplast...
- HEMATOPOIETIC STEM CELL GENE THERAPY: ASSESSING THE RELEVANCE OF PRE-CLINICAL MODELS.
- High efficiency restriction enzyme-free linear amplification-mediated polymerase chain reaction approach for tracking lentiviral integration sites does not abrogate re...
- Assessing the Risks of Genotoxicity in the Therapeutic Development of Induced Pluripotent Stem Cells.
- Dynamic clonal analysis of murine hematopoietic stem and progenitor cells marked by 5 fluorescent proteins using confocal and multiphoton microscopy.
- BCL2A1a Over-Expression in Murine Hematopoietic Stem and Progenitor Cells Decreases Apoptosis and Results in Hematopoietic Transformation.
- Eltrombopag and improved hematopoiesis in refractory aplastic anemia.
- Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy.
- Bone marrow homing and engraftment of human hematopoietic stem and progenitor cells is mediated by a polarized membrane domain.
- Hematopoietic stem cell engineering at a crossroads.
- Transient silencing of PTEN in human CD34(+) cells enhances their proliferative potential and ability to engraft immunodeficient mice.
- Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia.
- Insertion Sites in Engrafted Cells Cluster Within a Limited Repertoire of Genomic Areas After Gammaretroviral Vector Gene Therapy.
- Contributions of gene marking to cell and gene therapies.
- CD9 up-regulation on CD34+ cells with ingenol 3,20-dibenzoate does not improve homing in NSG mice.
- Patients, hematologists, and time.
- Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers.
- Ex vivo expansion of retrovirally transduced primate CD34+ cells results in overrepresentation of clones with MDS1/EVI1 insertion sites in the myeloid lineage after tr...
- Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate.
- No evidence for clonal selection due to lentiviral integration sites in human induced pluripotent stem cells.
- Gene therapy activates EVI1, destabilizes chromosomes.
- Keeping up with Blood: introducing our CME program.
- In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
- Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-t...
- Introducing "e-Blood".
- Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates.
- 'Ghostbusting' at blood.
- More frequent Blood transfusions.
- Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.
- Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population.
- Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors.
- HOXB4 and retroviral vectors: adding fuel to the fire.
- The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy.
- Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing.
- No evidence of clonal dominance in primates up to 4 years following transplantation of multidrug resistance 1 retrovirally transduced long-term repopulating cells.
- Hematopoietic stem-cell behavior in nonhuman primates.
- Transduction of rhesus macaque hematopoietic stem and progenitor cells with avian sarcoma and leukosis virus vectors.
- Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques.
- Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene.
- Antibody-mediated cell labeling of peripheral T cells with micron-sized iron oxide particles (MPIOs) allows single cell detection by MRI.
- Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.
- The yin and yang of stem cell gene therapy: insights into hematopoiesis, leukemogenesis, and gene therapy safety.
- Correction of the disease phenotype in canine leukocyte adhesion deficiency using ex vivo hematopoietic stem cell gene therapy.
- In vitro culture during retroviral transduction improves thymic repopulation and output after total body irradiation and autologous peripheral blood progenitor cell tr...
- Genotoxicity of retroviral integration in hematopoietic cells.
- Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque.
- Mobilization as a preparative regimen for hematopoietic stem cell transplantation.
- AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.
- Combination therapy with rFVIIa and platelets for hemorrhage in patients with severe thrombocytopenia and alloimmunization.
- Outcomes and risks of granulocyte colony-stimulating factor in patients with coronary artery disease.
- Large animal models for stem and progenitor cell analysis.
- Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells.
- Large granular lymphocytic proliferation-associated cyclic thrombocytopenia.
- A new direction for gene therapy: intrathymic T cell-specific lentiviral gene transfer.
- Stem cell gene transfer: insights into integration and hematopoiesis from primate genetic marking studies.
- Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner.
- Low-dose total body irradiation causes clonal fluctuation of primate hematopoietic stem and progenitor cells.
- Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.
- Gene therapy for hematologic disease: Don't throw the baby out with the bathwater!
- Genetic manipulation of hematopoietic stem cells.
- The impact of low-dose busulfan on clonal dynamics in nonhuman primates.
- MRI detection of single particles for cellular imaging.
- Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates.
- Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system.
- Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leuk...
- Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem c...
- Direct comparison of RD114-pseudotyped versus amphotropic-pseudotyped retroviral vectors for transduction of rhesus macaque long-term repopulating cells.
- Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells.
- Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells.
- Resetting the immune system in immune thrombocytopenic purpura: immunoablative strategies.
- Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing.
- Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene t...
- Retroviral transduction efficiency of G-CSF+SCF-mobilized peripheral blood CD34+ cells is superior to G-CSF or G-CSF+Flt3-L-mobilized cells in nonhuman primates.
- High-dose cyclophosphamide with autologous lymphocyte-depleted peripheral blood stem cell (PBSC) support for treatment of refractory chronic autoimmune thrombocytopenia.
- Prolonged multilineage clonal hematopoiesis in a rhesus recipient of CD34 positive cells marked with a RD114 pseudotyped oncoretroviral vector.
- Polyclonal long-term repopulating stem cell clones in a primate model.
- Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene.
- Plasticity and hematopoiesis: Circe's transforming potion?
- Retroviral transduction and engraftment ability of primate hematopoietic progenitor and stem cells transduced under serum-free versus serum-containing conditions.
- Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number.
- Thrombopoietic status of patients on haemodialysis.
Schools
Harvard Medical School
Boston City Hospital
National Institute Of Health
Doctors Specialties
- Hematology
Accepted Insurances
Awards
- Elected Member
Education
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Boston University Medical Center -
Harvard Medical School
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