Professor of Medicine, Professor of Oncology, Johns Hopkins University School of Medicine; Professor
Infectious Disease
Dr. Cynthia Sears, MD
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Cynthia Sears works in the field of Infectious Disease. She researched medicine at Jefferson Medical College. She over the years received 1 awards: "Elected Member". Cynthia Sears, MD has written publications. She has 85 publications published with PubMed. The lastest publication is: 'A clinicopathologic analysis of AIDS-related cryptosporidiosis.'
Publications
- Reduction of murine colon tumorigenesis driven by enterotoxigenic Bacteroides fragilis using cefoxitin treatment.
- The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints.
- Microbiota organization is a distinct feature of proximal colorectal cancers.
- The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients.
- John g. Bartlett: a transformative, visionary leader of johns hopkins infectious diseases.
- Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia.
- Stat3 Activation in Murine Colitis Induced by Enterotoxigenic Bacteroides fragilis.
- Clostridium difficile Carriage and Serum Antitoxin Responses in Children with Inflammatory Bowel Disease.
- Bacterial oncogenesis in the colon.
- Food poisoning syndromes.
- Molecular physiology and pathophysiology of tight junctions V. assault of the tight junction by enteric pathogens.
- The pathogenesis of cryptosporidiosis.
- New horizons for the infectious diseases specialist: how gut microflora promote health and disease.
- Vibrio cholerae ACE stimulates Ca(2+)-dependent Cl(-)/HCO(3)(-) secretion in T84 cells in vitro.
- Cloning, characterization, and chromosomal mapping of a phospholipase (lecithinase) produced by Vibrio cholerae.
- Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro.
- AIDS enteropathy.
- Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers.
- Association of Bacteroides fragilis with childhood diarrhea.
- Therapeutic dilemmas in the care of a human immunodeficiency virus-infected patient with vasculitis: case report.
- Seroepidemiology of Entamoeba histolytica in a slum in northeastern Brazil.
- Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.
- A clinicopathologic analysis of AIDS-related cryptosporidiosis.
- Clinical manifestations and risk factors of Pseudomonas aeruginosa infection in patients with AIDS.
- Dangers of empiric oral ciprofloxacin in the treatment of acute inflammatory diarrhea in children.
- Mechanisms of disease: protease functions in intestinal mucosal pathobiology.
- Infectious causes of persistent diarrhea.
- Monoclonal antibodies to the enterotoxin of Bacteroides fragilis: production, characterization, and immunodiagnostic application.
- The toxins of Bacteroides fragilis.
- A longitudinal study of Giardia lamblia infection in north-east Brazilian children.
- Plasmid-encoded toxin of enteroaggregative Escherichia coli is internalized by epithelial cells.
- Cryptosporidiosis in patients with AIDS: correlates of disease and survival.
- Regulation of intestinal guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) and protein kinase C.
- Cytoskeletal effects induced by pet, the serine protease enterotoxin of enteroaggregative Escherichia coli.
- Persistent diarrhea signals a critical period of increased diarrhea burdens and nutritional shortfalls: a prospective cohort study among children in northeastern Brazil.
- Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis.
- Bacteroides fragilis toxin rapidly intoxicates human intestinal epithelial cells (HT29/C1) in vitro.
- Bacteroides fragilis toxin exhibits polar activity on monolayers of human intestinal epithelial cells (T84 cells) in vitro.
- Evaluation of an antigen capture enzyme-linked immunosorbent assay for detection of Cryptosporidium oocysts.
- Cryptosporidiosis: the complexity of intestinal pathophysiology.
- Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children.
- Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis.
- Bacteroides fragilis toxin rearranges the actin cytoskeleton of HT29/C1 cells without direct proteolysis of actin or decrease in F-actin content.
- Enterotoxigenic Bacteroides fragilis.
- Molecular evolution of the pathogenicity island of enterotoxigenic Bacteroides fragilis strains.
- Longitudinal study of Cryptosporidium infection in children in northeastern Brazil.
- Environmental sources of Cryptosporidium in an urban slum in northeastern Brazil.
- Household epidemiology of Cryptosporidium parvum infection in an urban community in northeast Brazil.
- Detection of toxin production by Bacteroides fragilis: assay development and screening of extraintestinal clinical isolates.
- T84 cells in culture as a model for enteroaggregative Escherichia coli pathogenesis.
- Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin.
- Cryptosporidiosis in northeastern Brazilian children: association with increased diarrhea morbidity.
- Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene.
- Enterotoxigenic bacteroides fragilis: a potential instigator of colitis.
- Clostridium difficile: new therapeutic options.
- A dynamic partnership: celebrating our gut flora.
- Triazole cross-resistance among Candida spp.: case report, occurrence among bloodstream isolates, and implications for antifungal therapy.
- Mutation of the zinc-binding metalloprotease motif affects Bacteroides fragilis toxin activity but does not affect propeptide processing.
- Bacteroides fragilis enterotoxin induces intestinal epithelial cell secretion of interleukin-8 through mitogen-activated protein kinases and a tyrosine kinase-regulate...
- Shiga toxin-producing Escherichia coli as a possible etiological agent of chronic diarrhea.
- Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.
- Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.
- Perspective: alpha-bugs, their microbial partners, and the link to colon cancer.
- Bacteroides spp. and diarrhea.
- IV or not IV? Just one of the antibiotic questions in Whipple's disease.
- Enterotoxigenic Bacteroides fragilis (ETBF)-mediated colitis in Min (Apc+/-) mice: a human commensal-based murine model of colon carcinogenesis.
- A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
- Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes.
- Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.
- Healthcare epidemiology: gastrointestinal flu: norovirus in health care and long-term care facilities.
- Association of enterotoxigenic Bacteroides fragilis infection with inflammatory diarrhea.
- Giardia duodenalis assemblage, clinical presentation and markers of intestinal inflammation in Brazilian children.
- Bacteroides fragilis toxin stimulates intestinal epithelial cell shedding and gamma-secretase-dependent E-cadherin cleavage.
- Is nitazoxanide an effective treatment for patients with acquired immune deficiency syndrome-related cryptosporidiosis?
- The emerging clinical importance of non-O157 Shiga toxin-producing Escherichia coli.
- Identification and characterization of conjugative transposons CTn86 and CTn9343 in Bacteroides fragilis strains.
- The C-terminal region of Bacteroides fragilis toxin is essential to its biological activity.
- Heavy cryptosporidial infections in children in northeast Brazil: comparison of Cryptosporidium hominis and Cryptosporidium parvum.
- The Bacteroides fragilis toxin binds to a specific intestinal epithelial cell receptor.
- Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response.
- Bacteroides fragilis enterotoxin induces c-Myc expression and cellular proliferation.
- Modulation of bft expression by the Bacteroides fragilis pathogenicity island and its flanking region.
- Cryptosporidiosis stimulates an inflammatory intestinal response in malnourished Haitian children.
- Diversity of the metalloprotease toxin produced by enterotoxigenic Bacteroides fragilis.
Schools
Thomas Jefferson University
New York Hospital Cornell Med S
Meml Hospital Sloan Kettering Institute
New York Presbyterian HospitalWeill Cornell Med Center
University Va School Med
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
Education
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University of Virginia -
Memorial Sloan-Kettering Cancer Center -
New York Presbyterian Hospital - Cornell Campus -
Jefferson Medical College
Hospital
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Johns Hopkins Hospital
Drug Facts
| NPI NUMBER | 1558386995 | |
| NPPES Provider LastName | SEARS | |
| NPPES Provider FirstName | CYNTHIA | |
| NPPES Provider ZIPCode | 212870005 | |
| NPPES Provider State | MD | |
| Specialty Description | Infectious Disease | |
| Total Claim Count | 46.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1558386995 |
| Last Name Of The Provider | SEARS |
| First Name Of The Provider | CYNTHIA |
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