Physician
Family Medicine
Dr. David A. Brownstein, MD
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David Brownstein is an expert in the field of Family Medicine. He went to Wayne State University School of Medicine. Wayne State University School of Medicine is ranked 63/85 in Research/PrimaryCare. David A. Brownstein is also a published physician. He has 58 publication published. The most recent publication is: Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction.
Publications
- Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations.
- Variations in humanized and defined culture conditions supporting derivation of new human embryonic stem cell lines.
- A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess.
- Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).
- Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.
- A neurological phenotype in mice with DNA repair gene Ercc1 deficiency.
- A missense mutation in the murine Opa3 gene models human Costeff syndrome.
- Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.
- Real-time visualization of human prolactin alternate promoter usage in vivo using a double-transgenic rat model.
- Topical thymidine dinucleotide application protects against UVB-induced skin cancer in mice with DNA repair gene (Ercc1)-deficient skin.
- Expression of the neuroprotective slow Wallerian degeneration (WldS) gene in non-neuronal tissues.
- Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume.
- Mice with DNA repair gene Ercc1 deficiency in a neural crest lineage are a model for late-onset Hirschsprung disease.
- Expression of urocortin peptides in canine myocardium and plasma.
- 11?-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice.
- 11?-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice.
- Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1.
- Smooth muscle cell-specific knockout of androgen receptor: a new model for prostatic disease.
- A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression.
- Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla.
- Persistence of functional hepatocyte-like cells in immune-compromised mice.
- Haploinsufficiency of the murine Col3a1 locus causes aortic dissection: a novel model of the vascular type of Ehlers-Danlos syndrome.
- Enhanced hippocampal long-term potentiation and spatial learning in aged 11beta-hydroxysteroid dehydrogenase type 1 knock-out mice.
- Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estra...
- eEF1A2 and neuronal degeneration.
- Translation elongation factor eEF1A2 is essential for post-weaning survival in mice.
- Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression.
- Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet.
- Dermatitis and lymphadenitis resembling juvenile cellulitis in a four-year-old dog.
- Murine gammaherpesvirus-68 infection causes multi-organ fibrosis and alters leukocyte trafficking in interferon-gamma receptor knockout mice.
- Severe osteochondrosis in two 10-month-old beef calves.
- Role of tachykinins in the host response to murine gammaherpesvirus infection.
- Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet.
- Analysis of a novel strain of murine gammaherpesvirus reveals a genomic locus important for acute pathogenesis.
- Innate resistance to lethal mousepox is genetically linked to the NK gene complex on chromosome 6 and correlates with early restriction of virus replication by cells w...
- Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction.
- Diabetes mellitus associated with lymphocytic islet inflammation in a Charolais bull.
- Serial backcross analysis of genetic resistance to mousepox, using marker loci for Rmp-2 and Rmp-3.
- Chromosomal locations and gonadal dependence of genes that mediate resistance to ectromelia (mousepox) virus-induced mortality.
- Immunostimulation in mice infected with Sendai virus.
- Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox.
- Ectromelia virus replication in major target organs of innately resistant and susceptible mice after intravenous infection.
- Genetic determinants of lung virus titers and resistance to lethal Sendai virus pneumonia.
- Differential pathogenesis of lethal mousepox in congenic DBA/2 mice implicates natural killer cell receptor NKR-P1 in necrotizing hepatitis and the fifth component of ...
- Pathogenesis of infection with a virulent allotropic variant of minute virus of mice and regulation by host genotype.
- Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus. V. Genetics of resistance to the Moscow strain.
- In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice.
- Genetically engineered mice: the holes in the sum of the parts.
- The pathogenesis of infection with minute virus of mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants...
- Papilloma formation in human foreskin xenografts after inoculation of human papillomavirus type 16 DNA.
- Sendai viral pneumonia in aged BALB/c mice.
- Evidence that NK cells and interferon are required for genetic resistance to lethal infection with ectromelia virus.
- Dual infection with Pneumocystis carinii and Pasteurella pneumotropica in B cell-deficient mice: diagnosis and therapy.
- Alopecia areata with lymphocytic mural folliculitis affecting the isthmus in a thoroughbred mare.
- A novel transmembrane MSP-containing protein that plays a role in right ventricle development.
- Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy.
- The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice.
Schools
Wayne State University
Providence Hospital Med Ctrs
Doctors Specialties
- Family Medicine
Accepted Insurances
- Aetna
- Blue Cross Blue Shield
- CareSource
- Commercial Insurance Company
- Golden Rule
- Health Alliance
- Medical Mutual of Ohio
- Medicare MCR
- Priority Health
- United Healthcare
Education
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Providence Hospital and Medical Centers -
Wayne State University School of Medicine
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