Professor, Pediatrics, Medical College of Georgia at Georgia Health Sciences University
Pediatric Hematology & Oncology
Dr. David H. Munn, MD
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David Munn is an expert in the field of Pediatric Hematology & Oncology. He went to Medical College of Georgia School of Medicine. David Munn is a published doctor. He has 101 publications published. The most current publication "Immunotherapy with GD2 specific monoclonal antibodies."
Publications
- GvHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells.
- Canonical wnt signaling in dendritic cells regulates th1/th17 responses and suppresses autoimmune neuroinflammation.
- B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality.
- β-Catenin Promotes Regulatory T-cell Responses in Tumors by Inducing Vitamin A Metabolism in Dendritic Cells.
- TLR2-Dependent Activation of β-Catenin Pathway in Dendritic Cells Induces Regulatory Responses and Attenuates Autoimmune Inflammation.
- Activation of the STING Adaptor Attenuates Experimental Autoimmune Encephalitis.
- Increased T follicular helper cells and germinal center B cells are required for chronic GVHD (cGVHD) and bronchiolitis obliterans.
- Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T cell responses through the PD-1/PD-L1 axis.
- Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance.
- GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology.
- Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
- Epitope-optimized alpha-fetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma.
- Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses.
- Host programmed death ligand-1 is dominant over programmed death ligand-2 expression in regulating graft-versus-host disease lethality.
- Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration.
- An inherently bifunctional subset of foxp3(+) T helper cells is controlled by the transcription factor eos.
- Local Administration of TLR Ligands Rescues the Function of Tumor-Infiltrating CD8 T Cells and Enhances the Antitumor Effect of Lentivector Immunization.
- Indoleamine 2,3 dioxygenase and metabolic control of immune responses.
- IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan.
- Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia.
- Butyrate suppresses colonic inflammation through HDAC1-dependent Fas Upregulation and Fas-mediated apoptosis of T cells.
- Engineering DNA Nanoparticles as Immunomodulatory Reagents that Activate Regulatory T Cells.
- Immunoglobulin Fc Fragment Tagging Allows Strong Activation of Endogenous CD4 T Cells To Reshape the Tumor Milieu and Enhance the Antitumor Effect of Lentivector Immun...
- Blocking IDO activity to enhance anti-tumor immunity.
- Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection.
- Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?
- Physiologic Control of IDO Competence in Splenic Dendritic Cells.
- Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia.
- Physiologic control of the functional status of foxp3+ regulatory T cells.
- Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.
- Leishmania major attenuates host immunity by stimulating local indoleamine 2,3-dioxygenase expression.
- αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation.
- Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin...
- Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.
- Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization.
- Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.
- B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase.
- Zinc protoporphyrin IX stimulates tumor immunity by disrupting the immunosuppressive enzyme indoleamine 2,3-dioxygenase.
- Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype.
- Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality.
- Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia.
- IDO activates regulatory T cells and blocks their conversion into Th17-like T cells.
- Th17 cells in ovarian cancer.
- Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells.
- Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.
- Lentivector immunization stimulates potent CD8 T cell responses against melanoma self-antigen tyrosinase-related protein 1 and generates antitumor immunity in mice.
- IFN-gamma-indoleamine-2,3 dioxygenase acts as a major suppressive factor in 4-1BB-mediated immune suppression in vivo.
- Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.
- The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation.
- Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation.
- Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality.
- The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse.
- Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase.
- Role of CD28 in fatal autoimmune disorder in scurfy mice.
- Indoleamine 2,3-dioxygenase and tumor-induced tolerance.
- Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses.
- A high-affinity, tryptophan-selective amino acid transport system in human macrophages.
- Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Typ...
- Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis.
- GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.
- Dendritic cells have the option to express IDO-mediated suppression or not.
- Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis.
- Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.
- Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells.
- Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma.
- Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion.
- Tryptophan catabolism and regulation of adaptive immunity.
- Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase.
- Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection.
- Immunological concerns with bioengineering approaches.
- Tolerogenic antigen-presenting cells.
- Immune response to engineered tissues and cells: breakout session summary.
- Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses.
- Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis.
- Chemotherapy-induced myeloid suppressor cells and antitumor immunity: The Janus face of chemotherapy in immunomodulation.
- Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment.
- Targeted radiotherapy and immunotherapy of human neuroblastoma with GD2 specific monoclonal antibodies.
- Bifunctional thrombin inhibitors based on the sequence of hirudin45-65.
- Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors.
- Immunotherapy with GD2 specific monoclonal antibodies.
- HLA-G transgenic mice.
- Moral issues of human embryo research.
- Tryptophan catabolism and T cell responses.
- Policing pregnancy: Tregs help keep the peace.
- Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase.
- IDO in human gut graft-versus-host disease.
- Obesity related methylation changes in DNA of peripheral blood leukocytes.
- Recombinant lentivector as a genetic immunization vehicle for antitumor immunity.
- HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase-dependent mechanism.
- Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy.
- Lentivector expressing HBsAg and immunoglobulin Fc fusion antigen induces potent immune responses and results in seroconversion in HBsAg transgenic mice.
- Highlights of 10 years of immunology in Nature Reviews Immunology.
- Modulation of tumor tolerance in primary central nervous system malignancies.
- Lineage-specific transcription factors in unexpected places.
- Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: absence of toxicity due to saturating absorption.
- Cell-autonomous control of interferon type I expression by indoleamine 2,3-dioxygenase in regulatory CD19+ dendritic cells.
- Creating immune privilege: active local suppression that benefits friends, but protects foes.
- A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation.
- The tumor-draining lymph node as an immune-privileged site.
- Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation.
Schools
Medical College of Georgia
Rainbow BabiesChldns Hospital
Meml Sloan Kettering
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Education
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Memorial Sloan-Kettering Cancer Center -
Case Western Reserve University - University Hospitals -
Medical College of Georgia School of Medicine
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