Professor, Pathology, Anatomy and Cell Biology, Jefferson Medical College-Thos Jefferson Univ
Pathology
Dr. David S. Strayer, MD
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David S. Strayer, MD practices Pathology. He went to medical school at University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine is ranked 10 in research and 19 in primary care medicine David Strayer is a published doctor as well. He has 101 publications published. The latest was: Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome.
Publications
- Relationship Between the Chemokine Receptor CCR5 and Microglia in Neurological Disorders: Consequences of Targeting CCR5 on Neuroinflammation, Neuronal Death and Regen...
- The crosstalk hypothesis: Why language interferes with driving.
- Raphael Rubin, 1956-2011.
- Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.
- Ethanol protects from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor.
- Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases.
- Blood-Brain Barrier Abnormalities Caused by HIV-1 gp120: Mechanistic and Therapeutic Implications.
- HIV-1 Tat neurotoxicity: A model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes.
- Lymphocyte adhesion to CCR5 ligands is reduced by anti-CCR5 gene delivery.
- Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage.
- Gene transfer to the cerebellum.
- Efficient CNS gene delivery by intravenous injection.
- HIV-1 gp120-induced injury to the blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to oxidative stress.
- Titering replication-defective rSV40 vectors.
- Production of SV40-derived vectors.
- Blood-brain barrier abnormalities caused by exposure to HIV-1 gp120--protection by gene delivery of antioxidant enzymes.
- HIV-1 gp120-induced neuroinflammation: relationship to neuron loss and protection by rSV40-delivered antioxidant enzymes.
- HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes.
- A rat model of human immunodeficiency virus 1 encephalopathy using envelope glycoprotein gp120 expression delivered by SV40 vectors.
- Preventing HIV-1 Tat-induced neuronal apoptosis using antioxidant enzymes: mechanistic and therapeutic implications.
- Rat bone marrow progenitor cells transduced in situ by rSV40 vectors differentiate into multiple central nervous system cell lineages.
- Long-term gene expression in dividing and nondividing cells using SV40-derived vectors.
- In vivo gene transfer into rat bone marrow progenitor cells using rSV40 viral vectors.
- Current status of gene therapy strategies to treat HIV/AIDS.
- Paradigms for conditional expression of RNA interference molecules for use against viral targets.
- Hepatitis C virus replication in stably transfected HepG2 cells promotes hepatocellular growth and tumorigenesis.
- Gene therapy for human alpha1-antitrypsin deficiency in an animal model using SV40-derived vectors.
- Factors influencing the production of recombinant SV40 vectors.
- Durable cytotoxic immune responses against gp120 elicited by recombinant SV40 vectors encoding HIV-1 gp120 +/- IL-15.
- New technologies in research and diagnosis: implications and opportunities for Human Pathology, its authors, and its readership.
- Conditional expression of IFN-alpha and IFN-gamma activated by HBV as genetic therapy for hepatitis B.
- Inhibition of HIV-1 in the central nervous system by IFN-alpha2 delivered by an SV40 vector.
- Inhibiting AIDS in the central nervous system: gene delivery to protect neurons from HIV.
- Targeting CCR5 with siRNAs: using recombinant SV40-derived vectors to protect macrophages and microglia from R5-tropic HIV.
- Survival signaling in type II pneumocytes activated by surfactant protein-A.
- Trans-activated interferon-alpha2 delivered to T cells by SV40 inhibits early stages in the HIV-1 replicative cycle.
- Gene therapy using a simian virus 40-derived vector inhibits the development of in vivo human immunodeficiency virus type 1 infection of severe combined immunodeficien...
- Combination genetic therapy to inhibit HIV-1.
- Strain differences in Shope fibroma virus. An immunopathologic study.
- Gastric cytomegalovirus infection in bone marrow transplant patients: an indication of generalized disease.
- Malignant rabbit fibroma virus causes secondary immunosuppression in rabbits.
- Immunohistology of malignant rabbit fibroma virus--a comparative study with rabbit myxoma virus.
- Malignant rabbit fibroma virus: observations on the culture and histopathologic characteristics of a new virus-induced rabbit tumor.
- Immunity to pasteurellosis in compromised rabbits.
- Immunologic dysfunction during viral oncogenesis. II. Inhibition of cellular immunity to viral antigens by malignant rabbit fibroma virus.
- Immunologic dysfunction during viral oncogenesis. I. Nonspecific immunosuppression caused by malignant rabbit fibroma virus.
- Streptozotocin prevents development of nitrosamine-induced pancreatic cancer in the Syrian hamster.
- Acute myelomonocytic leukemia presenting as a primary cutaneous lymphoma of true histiocytes.
- Subtle clues to diagnosis of skin diseases by electron microscopy. Intracytoplasmic granules with lamellae in Fabry's disease.
- The histologic spectrum of the cutaneous mycobacterioses.
- Insulin-specific antibodies and insulitis in mice immunized with purified porcine insulin.
- Primary lymphoma of the liver.
- Cutaneous Hodgkin's disease.
- Proliferative responses of rabbit lymphocytes to Pasteurella multocida decrease with prolonged immunization.
- Adnexal metaplasia in carcinoma in situ of the skin.
- Carcinoma in situ of the skin: a review of histopathology.
- Histoplasmosis presenting as the carpal tunnel syndrome.
- Glucocorticoid responsiveness conferred by a cloned DNA binding protein.
- Levels of SP-A-anti-SP-A immune complexes in neonatal respiratory distress syndrome correlate with subsequent development of bronchopulmonary dysplasia.
- DNA binding proteins that amplify surfactant protein B gene expression: isolation and characterization.
- The viruses don't always read the books: engineered vaccines and gene therapy using viral vectors.
- In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors.
- Bone marrow-derived cells migrate to line the vessels of the CNS: opportunities for gene delivery to CNS vasculature.
- Gene transfer to the rhesus monkey brain using SV40-derived vectors is durable and safe.
- Intracisternal rSV40 administration provides effective pan-CNS transgene expression.
- Spleen necrosis virus-based vector delivery of anti-HIV-1 genes potently protects human hematopoietic cells from HIV-1 infection.
- Durability of transgene expression and vector integration: recombinant SV40-derived gene therapy vectors.
- Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmo...
- Reduction of lung injury by human surfactant treatment in respiratory distress syndrome.
- Human surfactant treatment of severe respiratory distress syndrome: pulmonary effluent indicators of lung inflammation.
- A 2-year follow up of babies enrolled in a European multicentre trial of porcine surfactant replacement for severe neonatal respiratory distress syndrome. Collaborativ...
- Acute effects of a single dose of porcine surfactant on patients with the adult respiratory distress syndrome.
- Deletion of the growth factor gene related to EGF and TGF alpha reduces virulence of malignant rabbit fibroma virus.
- Leporine acquired immune deficiency disease.
- Divergence of primate ribosomal RNA genes as assayed by restriction enzyme analysis.
- Deletion analysis of two tandemly arranged virulence genes in myxoma virus, M11L and myxoma growth factor.
- An ancestral amplification of DNA in primates.
- Addition of deoxynucleotides to an RNA primer by a DNA polymerase in human platelets.
- Three organizations of human DNA.
- Extremely high levels of natural killer cells in angioimmunoblastic lymphadenopathy.
- HHV-6 reactivation in chronic fatigue syndrome.
- HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy.
- Perfluorochemical liquid-adenovirus suspensions enhance gene delivery to the distal lung.
- In vivo gene transfer to the CNS using recombinant SV40-derived vectors.
- Prolonged hemophagocytic lymphohistiocytosis syndrome as an initial presentation of Hodgkin lymphoma: a case report.
- Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microg...
- Dopaminergic neurotoxicity of HIV-1 gp120: reactive oxygen species as signaling intermediates.
- Delivering genes to the organ-localized immune system: long-term results of direct intramarrow transduction.
- What they are, how they work and why they do what they do? The story of SV40-derived gene therapy vectors and what they have to offer.
- Using gene delivery to protect HIV-susceptible CNS cells: inhibiting HIV replication in microglia.
- Mechanisms of alpha1-antitrypsin inhibition of cellular serine proteases and HIV-1 protease that are essential for HIV-1 morphogenesis.
- What can SV40-derived vectors do for gene therapy?
- Immune responses against SIV envelope glycoprotein, using recombinant SV40 as a vaccine delivery vector.
- Exploiting hepatitis C virus activation of NFkappaB to deliver HCV-responsive expression of interferons alpha and gamma.
- HIV-1 proprotein processing as a target for gene therapy.
- Viral vectors for gene therapy: past, present and future.
- Protecting from R5-tropic HIV: individual and combined effectiveness of a hammerhead ribozyme and a single-chain Fv antibody that targets CCR5.
- Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis.
- Conditional expression of alpha1-antitrypsin delivered by recombinant SV40 vectors protects lymphocytes against HIV.
- Replication-deficient rSV40 mediate pancreatic gene transfer and long-term inhibition of tumor growth.
Schools
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Barnes Jewish Hospital
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Education
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Washington University - Barnes-Jewish Hospital -
University of Chicago Pritzker School of Medicine
Hospital
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Thomas Jefferson University Hospital
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