Associate Vice President for Medical Affairs, University of Iowa Health Care; Professor of Anesthesiology, Pharmacology and Biochemistry

Anesthesiology

Debra Schwinn works in the field of Anesthesiology. She graduated from Stanford University School of Medicine. Stanford University School of Medicine is one of the top medical schools in the US. Stanford University School of Medicine has a rank of 2 in research and a 25 in primary care She over the years received 1 awards: "National Academy of Medicine, 2002". Debra Schwinn is also published. She has 101 publications published. The lastest publication: "Alpha1-adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha1-adrenergic receptor subtypes at four distinct levels.'

Publications

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• Fostering interprofessional teamwork in an academic medical center: Near-peer education for students during gross medical anatomy.
• Alpha1a-Adrenoceptor Genetic Variant Induces Cardiomyoblast to Fibroblast-like Cell Transition via Distinct Signaling Pathways.
• Alpha1a-Adrenoceptor Genetic Variant Triggers Vascular Smooth Muscle Cell Hyperproliferation and Agonist Induced Hypertrophy via EGFR Transactivation Pathway.
• Stimulation of α1a Adrenergic Receptors Induces Cellular Proliferation or Antiproliferative Hypertrophy Dependent Solely on Agonist Concentration.
• The role of alpha1-adrenergic receptor subtypes in lower urinary tract symptoms.
• Novel role for alpha1-adrenergic receptor subtypes in lower urinary tract symptoms.
• Alpha 1-adrenergic receptor regulation: basic science and clinical implications.
• Immortalization of a human prostate stromal cell line using a recombinant retroviral approach.
• Endogenous circulating sympatholytic factor in orthostatic intolerance.
• Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).
• alpha1-adrenergic receptors in the lower urinary tract and vascular bed: potential role for the alpha1d subtype in filling symptoms and effects of ageing on vascular e...
• Alpha2-adrenergic receptors in human dorsal root ganglia: predominance of alpha2b and alpha2c subtype mRNAs.
• In situ hybridization of adrenergic receptor mRNA in brain.
• Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age.
• Characterization of alpha-adrenoceptor subtypes in the corpus cavernosum of patients undergoing sex change surgery.
• Multiple potential regulatory elements in the 5'' flanking region of the human alpha 1a-adrenergic receptor.
• Activation of extracellular signal-regulated kinase in human prostate cancer.
• Molecular pharmacology of human alpha1-adrenergic receptors: unique features of the alpha 1a-subtype.
• Alpha1-adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha1-adrenergic receptor subtypes at four distinct levels.
• Acute myocardial beta-adrenergic receptor dysfunction after cardiopulmonary bypass in patients with cardiac valve disease. Duke Heart Center Perioperative Desensitizat...
• Acute depression of myocardial beta-adrenergic receptor signaling during cardiopulmonary bypass: impairment of the adenylyl cyclase moiety. Duke Heart Center Periopera...
• Alpha1-adrenergic receptor subtypes in human detrusor.
• Writing successful research proposals for medical science.
• New developments in cardiovascular adrenergic receptor pharmacology: molecular mechanisms and clinical relevance.
• Transcriptional regulation of alpha-1 adrenergic receptors.
• Characterization of GRK2-catalyzed phosphorylation of the human substance P receptor in Sf9 membranes.
• In situ hybridization: identification of rare mRNAs in human tissues.
• Transcriptional regulation of the human alpha1a-adrenergic receptor gene. Characterization Of the 5'-regulatory and promoter region.
• Expression and regulation of alpha 1-adrenergic receptors in human tissues.
• Pharmacology of tamsulosin: saturation-binding isotherms and competition analysis using cloned alpha 1-adrenergic receptor subtypes.
• Effect of chronic and acute thyroid hormone reduction on perioperative outcome.
• A critical period for the role of thyroid hormone in development of renal alpha-adrenergic receptors.
• Cardiopulmonary bypass and circulatory arrest increase endothelin-1 production and receptor expression in the lung.
• Molecular biology and medicine. A primer for the clinician.
• Effects of androgen deprivation on prostate alpha 1-adrenergic receptors.
• alpha 2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels.
• Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity.
• Human G(alpha q): cDNA and tissue distribution.
• Effects of cardiopulmonary bypass and circulatory arrest on endothelium-dependent vasodilation in the lung.
• Hypotension resistant to therapy with alpha receptor agonists complicating cardiopulmonary bypass: lithium as a potential cause.
• Cardiovascular effects of intravenous triiodothyronine in patients undergoing coronary artery bypass graft surgery. A randomized, double-blind, placebo- controlled tri...
• Acute myelogenous leukemia: implications of acute blast crisis and cardiopulmonary bypass.
• Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.
• Adrenoceptors as models for G protein-coupled receptors: structure, function and regulation.
• Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology.
• Expression of alpha 1-adrenergic receptor subtype mRNA in rat tissues and human SK-N-MC neuronal cells: implications for alpha 1-adrenergic receptor subtype classifica...
• Localization of messenger RNA for three distinct alpha 2-adrenergic receptor subtypes in human tissues. Evidence for species heterogeneity and implications for human p...
• Stability of the beta-adrenergic receptor/adenylyl cyclase pathway of pediatric myocardium after brain death.
• Do not resuscitate (DNR) orders during surgery: ethical foundations for institutional policies in the United States.
• Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.
• Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate.
• The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2.
• Blockade of endothelin-converting enzyme reduces pulmonary hypertension after cardiopulmonary bypass and circulatory arrest.
• Distribution of beta 3-adrenoceptor mRNA in human tissues.
• Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death.
• Adrenergic receptors: unique localization in human tissues.
• Classification of alpha 1-adrenoceptor subtypes.
• Complications in long-term survivors of cardiac transplantation.
• Postoperative complications due to paradoxical vocal cord motion.
• Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
• alpha 1-Adrenergic responsiveness during coronary artery bypass surgery: effect of preoperative ejection fraction.
• Intraoperative monitoring of brainstem auditory evoked potentials following emergency evacuation of a cerebellar vascular malformation.
• Time course and hemodynamic effects of alpha-1-adrenergic bolus administration in anesthetized patients with myocardial disease.
• Atrial natriuretic peptide.
• Pro-choice/abortion?
• Isoflurane-induced vasodilation: role of the alpha-adrenergic nervous system.
• Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.
• The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family.
• Beta-adrenergic receptor function in surgical patients.
• Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.
• Functional effects of activation of alpha-1 adrenoceptors by dexmedetomidine: in vivo and in vitro studies.
• Multiple potential regulatory elements in the 5'' flanking region of the beta 3-adrenergic receptor.
• Desensitization of myocardial beta-adrenergic receptors during cardiopulmonary bypass. Evidence for early uncoupling and late downregulation.
• The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity.
• Management of a difficult intubation during acute myocardial ischemia following a failed angioplasty.
• Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements.
• A two-allele PstI RFLP for the alpha-1C adrenergic receptor gene (ADRA1C).
• Pharmacologic characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype.
• The locus coeruleus. Site of hypnotic actions of alpha 2-adrenoceptor agonists?
• Genomics and the circulation.
• Genetic factors contribute to bleeding after cardiac surgery.
• Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease.
• Genetics and patient outcome after cardiac surgery: unravelling translational findings.
• Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
• The new age of medical genomics.
• Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway.
• Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function.
• Anesthesiology physician scientists in academic medicine: a wake-up call.
• Alpha1-adrenergic antagonists and floppy iris syndrome: tip of the iceberg?
• New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics.
• APOE polymorphism is associated with risk of severe sepsis in surgical patients.
• Characteristics of a human prostate stromal cell line related to its use in a stromal-epithelial coculture model for the study of cancer chemoprevention.
• Pharmacogenomics of ?-adrenergic receptor physiology and response to ?-blockade.
• Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics.
• Case 4-2011: malignant hyperthermia in cardiac surgery.
• 2010 Walter C. Randall lecture in biomedical ethics. Scientific integrity: positive & negative academic/industry relationships.
• Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.
• The United States critical illness and injury trials group: an introduction.
• Lipid rafts constrain basal alpha(1A)-adrenergic receptor signaling by maintaining receptor in an inactive conformation.
• Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical isch...

Schools

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• Stanford University

• Pennsylvania Hospital

• Hospital Of The University Of Pennsylvania

• Duke University Med Center

Doctors Specialties

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• Anesthesiology

Accepted Insurances

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Awards

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• National Academy of Medicine, 2002

Education

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• Duke University Hospital
• University of Pennsylvania Health System
• Pennsylvania Hospital - University of Pennsylvania Health System
• Stanford University School of Medicine

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