Associate Professor, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute Division of Cardiology, Department of Medicine UPMC and University of Pittsburgh School of Medicine
Cardiology
Dr. Dennis C. Bruemmer, MD
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Dennis C. Bruemmer, MD practices Cardiology. He graduated from University of Kentucky College of Medicine. University of Kentucky College of Medicine is ranked 63 in research and 72 in primary care medicine Dennis Bruemmer has written publications. He has 67 publications published with PubMed. The lastest publication is: 'Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition.'
Publications
- Differential Regulation of Telomerase Reverse Transcriptase Promoter Activation and Protein Degradation by Histone Deacetylase Inhibition.
- Epigenetic regulation of the NR4A orphan nuclear receptor NOR1 by histone acetylation.
- Osteopontin: A novel regulator at the cross roads of inflammation, obesity and Diabetes.
- Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis.
- Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms.
- Response to "Lack of evidence to support a beneficial role for glutathione depletion on body weight or glucose intolerance"
- Novel Mechanisms of Abdominal Aortic Aneurysms.
- Transient Exposure of Neonatal Female Mice to Testosterone Abrogates the Sexual Dimorphism of Abdominal Aortic Aneurysms.
- Targeting angiogenesis as treatment for Obesity.
- Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms.
- Regulation of Peroxisome Proliferator-Activated Receptor-? by Angiotensin II Via Transforming Growth Factor-?1-Activated p38 Mitogen-Activated Protein Kinase in Aortic...
- Glutathione depletion prevents diet-induced Obesity and enhances insulin sensitivity.
- Transcriptional regulation of S phase kinase-associated protein 2 by NR4A orphan nuclear receptor NOR1 in vascular smooth muscle cells.
- Race-ethnicity as an effect modifier of the association between HbAlc and mortality in U.S. adults without diagnosed Diabetes.
- Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis.
- Epigenetic regulation of vascular smooth muscle cell proliferation and neointima formation by histone deacetylase inhibition.
- Telomerase activation in atherosclerosis and induction of telomerase reverse transcriptase expression by inflammatory stimuli in macrophages.
- Telomerase Deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation.
- Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.
- Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction With PPAR{gamma}.
- NR4A orphan nuclear receptors: transcriptional regulators of gene expression in Metabolism and vascular biology.
- Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke.
- Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis.
- Intensive glycemic control and cardiovascular Disease: an update.
- Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells.
- A new glucagon and GLP-1 co-agonist eliminates Obesity in rodents.
- Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury.
- The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.
- Liver X receptors as therapeutic targets in Metabolism and atherosclerosis.
- Phosphorylated troglitazone activates PPARgamma and inhibits vascular smooth muscle cell proliferation and proteoglycan synthesis.
- Transcriptional Control of Vascular Smooth Muscle Cell Proliferation by Peroxisome Proliferator-Activated Receptor-gamma: Therapeutic Implications for Cardiovascular D...
- Zinc deficiency alters lipid Metabolism in LDL receptor deficient mice treated with rosiglitazone.
- Osteopontin mediates Obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.
- PPARalpha agonists suppress osteopontin expression in macrophages and decrease plasma levels in patients with type 2 Diabetes.
- C-Peptide in insulin resistance and vascular complications: teaching an old dog new tricks.
- The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation.
- Osteopontin Deficiency protects mice from Dextran sodium sulfate-induced colitis.
- Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells.
- Liver x receptors: potential novel targets in cardiovascular Diseases.
- Transcriptional repression of ATP-binding cassette transporter A1 gene in macrophages: a novel atherosclerotic effect of angiotensin II.
- Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin Type 2 receptor activation.
- Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference With activator protein-1 signaling pathways.
- New targets for PPARgamma in the vessel wall: implications for restenosis.
- Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.
- Will the potential of peroxisome proliferator-activated receptor agonists be realized in the clinical setting?
- C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells.
- Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis.
- Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart.
- Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.
- Peroxisome proliferator-activated receptor gamma: implications for cardiovascular Disease.
- Thiazolidinedione regulation of smooth muscle cell proliferation.
- Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice.
- Expression of minichromosome maintenance proteins in vascular smooth muscle cells is ERK/MAPK dependent.
- Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells.
- PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic Cancer cells.
- p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells.
- Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenou...
- A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth.
- Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.
- Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells.
- Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.
- PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting With Smad4.
- Increased expression of Renal neutral endopeptidase in severe heart failure.
- TGF-beta(1) induces peroxisome proliferator-activated receptor gamma1 and gamma2 expression in human THP-1 monocytes.
- TNFalpha inhibits insulin's antiapoptotic signaling in vascular smooth muscle cells.
- Expression of CD40 in vascular smooth muscle cells and macrophages is associated With early development of human atherosclerotic lesions.
Schools
Universitaet Hamburg Fachbereich Medizin
Conditions Treated
- Abnormal Thyroid
- AdRenal Incidentaloma
- AdRenal Insufficiency
- Calcium Metabolism Disorders
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Doctors Specialties
- Cardiology
Accepted Insurances
Education
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University of Kentucky College of Medicine -
UCLA Medical Center -
University of Hamburg Faculty of Medicine
Hospital
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University of Kentucky Albert B. Chandler Hospital
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