Assistant Professor, Medicine-Hematology, University of Tennessee Health Science Center College of Medicine
Hematology
Dr. Derek A. Persons, MD
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Doctor Derek A. Persons, MD is an expert in the field of Hematology. He researched medicine at Duke University School of Medicine. Duke University School of Medicine is a top medical college. Duke University School of Medicine is ranked 8 in research and 29 in primary care medicine Derek Persons is also published. He has 70 publications published. The lastest publication: "Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis.'
Publications
- Long noncoding RNA Saf and splicing factor 45 increase soluble Fas and resistance to apoptosis.
- Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34(+) cells.
- Genomic analyses of pneumococci from children with sickle cell disease expose host-specific bacterial adaptations and deficits in current interventions.
- Nfix is a novel regulator of murine hematopoietic stem and progenitor cell survival.
- Development of gene therapy for Thalassemia.
- Cell Membrane-associated Heparan Sulfate Is a Receptor for Prototype Foamy Virus in Human, Monkey, and Rodent Cells.
- Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin.
- Therapeutic in vivo selection of thymic-derived natural T regulatory cells following non-myeloablative hematopoietic stem cell transplant for IPEX.
- Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.
- Gene Therapy for Canine Leukocyte Adhesion Deficiency with Lentiviral Vectors Using the Murine Stem Cell Virus and Human Phosphoglycerate Kinase Promoters.
- Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer.
- Solving the problem of γ-retroviral vectors containing long terminal repeats.
- Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-Thalassemia.
- Gene therapy: Targeting β-thalassaemia.
- Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model.
- The challenge of obtaining therapeutic levels of genetically modified hematopoietic stem cells in beta-Thalassemia patients.
- Transduction of human primitive repopulating hematopoietic cells with lentiviral vectors pseudotyped with various envelope proteins.
- Lentiviral vector gene therapy: effective and safe?
- A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythrobl...
- Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease.
- In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene.
- Amelioration of murine beta-Thalassemia through drug selection of hematopoietic stem cells transduced with a lentiviral vector encoding both gamma-globin and the MGMT ...
- Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-t...
- Genetically modified CD34+ hematopoietic stem cells contribute to turnover of brain perivascular macrophages in long-term repopulated primates.
- Optimized lentiviral vector design improves titer and transgene expression of vectors containing the chicken beta-globin locus HS4 insulator element.
- Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin.
- Hematopoietic stem cell gene transfer for the treatment of hemoglobin disorders.
- Progress toward safe and effective gene therapy for beta-Thalassemia and sickle cell disease.
- Globin lentiviral vector insertions can perturb the expression of endogenous genes in beta-thalassemic hematopoietic cells.
- An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation.
- A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells.
- Hypersusceptibility to invasive pneumococcal infection in experimental sickle cell disease involves platelet-activating factor receptor.
- Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia.
- Mobilization and mechanism of transcription of integrated self-inactivating lentiviral vectors.
- Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny.
- Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells.
- Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-Thalassemia.
- Gene therapy for the hemoglobin disorders.
- Hematopoietic cells and osteoblasts are derived from a common marrow progenitor after bone marrow transplantation.
- Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system.
- Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem c...
- Update on gene therapy for hemoglobin disorders.
- Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression.
- Successful treatment of murine beta-Thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells.
- Development of gene therapy for hemoglobin disorders.
- The degree of phenotypic correction of murine beta -Thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromos...
- High-level erythroid lineage-directed gene expression using globin gene regulatory elements after lentiviral vector-mediated gene transfer into primitive human and mur...
- In vivo selection to improve gene therapy of hematopoietic disorders.
- Functional amelioration of murine galactosialidosis by genetically modified bone marrow hematopoietic progenitor cells.
- Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood.
- Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment.
- Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo.
- Functional requirements for phenotypic correction of murine beta-Thalassemia: implications for human gene therapy.
- Gene therapy for the hemoglobin disorders: past, present, and future.
- High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34(+) cells.
- Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.
- Adenovirus-mediated expresssion of the murine ecotropic receptor facilitates transduction of human hematopoietic cells with an ecotropic retroviral vector.
- High-efficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells.
- Enforced expression of the GATA-2 transcription factor blocks normal hematopoiesis.
- Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells.
- In vivo selection of retrovirally transduced hematopoietic stem cells.
- Tumor lysis syndrome and acute renal failure after treatment of non-small-cell lung carcinoma with combination irinotecan and cisplatin.
- An improved method for generating retroviral producer clones for vectors lacking a selectable marker gene.
- Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro...
- Fluconazole and Candida krusei fungemia.
- Retroviral transduction of protein kinase C-gamma into cytotoxic T lymphocyte clones leads to immortalization with retention of specific function.
- Protein kinase C gamma expression mimics phorbol ester-induced transcriptional activation of a murine VL30 enhancer element.
- Increased expression of glycolysis-associated genes in oncogene-transformed and growth-accelerated states.
- Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA.
Schools
Duke Univ Sch Of Med
Duke University Med Center
St Jude Rsch Hospital
Procedures Preformed
- Cardiac MRI (Magnetic Resonance Imaging) of Heart or Chest
Conditions Treated
- Neutropenia
- Thalassemia
Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
Accepted Insurances
Education
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Duke University Hospital -
Duke University School of Medicine
Hospital
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University of Tennessee Medical Center
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