Chair, Department of Medicine, Northwestern University Medical School
Cardiology
Dr. Douglas B. Vaughan, PHD
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Douglas Vaughan practices Cardiology. He went to medical school at University of Texas Southwestern Medical School. He over the years received 4 awards: "Elected Member", "Member", "Super Doctor" and "Fellow (FACC)". Douglas B. Vaughan, PHD has written publications. He has 46 publications published with PubMed. The lastest paper is: 'MiR-125b is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis.'
Publications
- MiR-125b is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis.
- Role of Plasminogen Activator Inhibitor-1 in Senescence and Aging.
- PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.
- Going Mobile: Enhanced Recovery From Myocardial Infarction via Stem Cell Mobilization and Homing for Tissue Repair.
- Consuming a balanced high fat diet for 16 weeks improves body composition, inflammation and vascular function parameters in obese premenopausal women.
- Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nomega-nitro-L-arginine methyl ester-induced hypertension and vascular senescence.
- Functionally stable plasminogen activator inhibitor-1 in a family with cardiovascular disease and vitiligo.
- Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through MER Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction.
- Molecular basis of organ fibrosis: Potential therapeutic approaches.
- Global gene expression profiling in PAI-1 knockout murine heart and kidney: molecular basis of cardiac-selective fibrosis.
- A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.
- Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial.
- A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis.
- A plasminogen activator inhibitor-1 inhibitor reduces airway remodeling in a murine model of chronic asthma.
- Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): Differential expression of microRNAs during EndMT.
- Fibrosis: is it a coactivator disease?
- PAI-1 in Tissue Fibrosis.
- Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateT...
- PAI-1 antagonists: the promise and the peril.
- Enhanced functional stability of plasminogen activator inhibitor-1 in patients with livedoid vasculopathy.
- Endothelial biology in the post-menopausal obese woman.
- Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production.
- Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.
- Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: involvement of constitutive transforming growth factor-beta signaling a...
- LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2...
- Expression and regulation of soluble epoxide hydrolase in adipose tissue.
- Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bon...
- Hybrid cardiovascular procedures.
- Short term effects of GnRH agonists on plasma fibrinolytic balance in patients with advanced prostate cancer.
- Male-female differences in the genetic regulation of t-PA and PAI-1 levels in a Ghanaian population.
- Response of fractional synthesis rate (FSR) of fibrinogen, concentration of D-dimer and fibrinolytic balance to physical activity-based intervention in obese children.
- Evidence of metabolic syndrome in lean children with premature pubarche at diagnosis.
- Clinical implications of the contrasting effects of in vivo thrombin receptor activation (protease-activated receptor type 1) on the human vasculature.
- Low-dose growth hormone administration mobilizes endothelial progenitor cells in healthy adults.
- Calmodulin kinase II inhibition disrupts cardiomyopathic effects of enhanced green fluorescent protein.
- Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells.
- Task force 7: training in cardiovascular research.
- Transgenic over-expression of plasminogen activator inhibitor-1 results in age-dependent and gender-specific increases in bone strength and mineralization.
- A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1.
- The effects of polymorphisms in genes from the renin-angiotensin, bradykinin, and fibrinolytic systems on plasma t-PA and PAI-1 levels are dependent on environmental c...
- PAI-1 antagonists: predictable indications and unconventional applications.
- Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency.
- Plasminogen activator inhibitor-1 has a circadian rhythm in blind individuals.
- Transgenic overexpression of plasminogen activator inhibitor-1 promotes the development of polycystic ovarian changes in female mice.
- Nitric oxide prevents alveolar senescence and emphysema in a mouse model.
Doctors Specialties
- Clinical Psychology
- Cardiology
Accepted Insurances
Awards
- Elected Member
- Member
- Super Doctor
- Fellow (FACC)
Education
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Brigham and Women's Hospital -
University of Texas Southwestern Medical School
Hospital
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Northwestern Memorial Hospital
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