Professor, Internal Medicine, Virginia Commonwealth University, Medical College of Virginia School of Medicine
Gastroenterology
Dr. Douglas M. Heuman, MD
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Douglas Heuman works in the field of Gastroenterology. He researched medicine at University of Massachusetts Medical School. University of Massachusetts Medical School has a rank of 49 in research and a 12 in primary care He received 3 awards: "Fellow (AGAF)", "Fellows" and "Fellow (FACG)". Douglas Heuman has written publications. He has 102 publications published with PubMed. The lastest publication is: 'Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7 alpha-hydroxylase.'
Publications
- Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Cabozantinib.
- Salivary Microbiota Reflects Changes in Gut Microbiota in Cirrhosis with Hepatic Encephalopathy.
- Correction of hyponatraemia improves cognition, quality of life, and brain oedema in cirrhosis.
- Systems biology analysis of omeprazole therapy in cirrhosis demonstrates significant shifts in gut microbiota composition and function.
- Cognitive Reserve Is a Determinant of Health-related Quality of Life in Patients With Cirrhosis, Independent of Covert Hepatic Encephalopathy and Model for End-Stage L...
- Covert Hepatic Encephalopathy Is Independently Associated With Poor Survival and Increased Risk of Hospitalization.
- Effects of Obstructive Sleep Apnea on Sleep Quality, Cognition, and Driving Performance in Patients with Cirrhosis.
- Colonic inflammation and secondary bile acids in alcoholic cirrhosis.
- Validation of EncephalApp, Smartphone-based Stroop Test, for the Diagnosis of Covert Hepatic Encephalopathy.
- Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis.
- Enhancement of functional connectivity, working memory and inhibitory control on multi-modal brain MR imaging with Rifaximin in Cirrhosis: Implications for the gut-liv...
- Diagnosis of Covert Hepatic Encephalopathy Without Specialized Tests.
- The Cirrhosis Dysbiosis Ratio defines Changes in the Gut Microbiome Associated with Cirrhosis and its Complications.
- Non-selective beta-blockers are not associated with serious infections in veterans with cirrhosis.
- Differential Impact of Hyponatremia and Hepatic Encephalopathy on Health-Related Quality of Life and Brain Metabolite Abnormalities in Cirrhosis.
- Effect of obstructive sleep apnea on the sleep architecture in cirrhosis.
- Coronary events in patients undergoing orthotopic liver transplantation: perioperative evaluation and management.
- The stroop smartphone APP is a short and valid method toscreen for minimal hepatic encephalopathy.
- Modulation of the fecal bile acid profile by gut microbiota in cirrhosis.
- Proton pump inhibitors are associated with a high rate of serious infections in veterans with decompensated cirrhosis.
- Asymmetric Di-methyl Arginine is Strongly Associated with Cognitive Dysfunction and Brain MR Spectroscopic Abnormalities in Cirrhosis.
- The Colonic Mucosal Microbiome Differs from Stool Microbiome in Cirrhosis and Hepatic Encephalopathy and is Linked to Cognition and Inflammation.
- Cognitive Performance as a predictor of hepatic encephalopathy in pre-transplant cirrhotic patients receiving psychoactive medications: A prospective study.
- A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy.
- Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: A cost-effectiveness analysis.
- Muscle and mortality in cirrhosis.
- Linkage of Gut Microbiome with Cognition in Hepatic Encephalopathy.
- Driving Simulation Can Improve Insight into Impaired Driving Skills in Cirrhosis.
- The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers.
- Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy.
- Persistence of cognitive impairment after resolution of overt hepatic encephalopathy.
- Hyponatremia in cirrhosis answers and questions.
- Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test.
- Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites.
- The effect of fatigue on driving skills in patients with hepatic encephalopathy.
- 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.
- Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome.
- MELD-XI: a rational approach to "sickest first" liver transplantation in cirrhotic patients requiring anticoagulant therapy.
- Safety of an Immune-enhancing nutrition supplement in cirrhotic patients with history of encephalopathy.
- High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhotics.
- Persistent ascites and low serum sodium identify patients with cirrhosis and low MELD scores who are at high risk for early death.
- Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent Hepatitis C following liver transplantation.
- Utility of the MELD score for assessing 3-month survival in patients with liver cirrhosis: one more positive answer.
- Fructose diphosphate attenuates the acetaminophen-induced liver injury in the rat evidence for involvement of nitric oxide.
- Mikulicz syndrome associated with a malignant large cell gastric lymphoma: a case report and review of the literature.
- Cholesterol enhances membrane-damaging properties of model bile by increasing the intervesicular-intermixed micellar concentration of hydrophobic bile salts.
- Long-term management of cirrhosis. Appropriate supportive care is both critical and difficult.
- Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis.
- Small Intestinal neoplasms.
- The source of the bile: the legacy of Mathias Möckel.
- PROMIS computerised adaptive tests are dynamic instruments to measure health-related quality of life in patients with cirrhosis.
- Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes.
- Physiological effects of enteral and parenteral feeding on pancreaticobiliary secretion in humans.
- Is hepatic transplantation justified for primary liver Cancer?
- Use of desirability functions to evaluate health status in patients with cirrhosis.
- Effects of hepatic impairment on the pharmacokinetics of nilotinib: an open-label, single-dose, parallel-group study.
- Clostridium difficile is associated with poor outcomes in patients with cirrhosis: A national and tertiary center perspective.
- Pharmacokinetic characterization of the novel pulmonary delivery excipient fumaryl diketopiperazine.
- Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatoHepatitis and Hepatitis C.
- Multimodality therapy and liver transplantation in patients with cirrhosis and hepatocellular carcinoma: 6 years, single-center experience.
- Gastric duplication cyst communicating with aberrant pancreatic duct: a rare cause of recurrent acute pancreatitis.
- Regulation of hepatocyte lipid metabolism and inflammatory Response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate.
- Should a radiological diagnosis of hepatocellular carcinoma be routinely confirmed by a biopsy? No.
- Region 11 MELD Na exception prospective study.
- Effect of hyponatraemia on outcomes following orthotopic liver transplantation.
- Incidence of prolonged length of stay after orthotopic liver transplantation and its influence on outcomes.
- Development and application of a polymerase chain reaction assay for the detection and enumeration of bile acid 7alpha-dehydroxylating bacteria in human feces.
- Cutae morphea associated with chronic Hepatitis C.
- Comparison of the effects of intravenously and orally administered esomeprazole on acid output in patients with symptoms of gastro-oEsophageal reflux disease.
- Disruption of sleep architecture in minimal hepatic encephalopathy and ghrelin secretion.
- Predictors of the recurrence of hepatic encephalopathy in lactulose-treated patients.
- Effect of cholylsarcosine on hepatic cholesterol and bile acid synthesis and bile secretion in rats.
- Function and regulation of hydroxylases involved in the bile acid biosynthesis pathways.
- Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate.
- Regulation of bile acid synthesis. V. Inhibition of conversion of 7-dehydrocholesterol to cholesterol is associated with down-regulation of cholesterol 7 alpha-hydroxy...
- Effects of perturbations in hepatic free and esterified cholesterol pools on bile acid synthesis, cholesterol 7 alpha-hydroxylase, HMG-CoA reductase, acyl-CoA:choleste...
- Regulation of bile acid synthesis.
- Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes.
- Physiological Responses to increased dietary cholesterol: the case of the egg man.
- Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. In vivo studies in the rat.
- Regulation of cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat.
- Effect of hydrophobic bile acids on 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and mRNA levels in the rat.
- Receptor-mediated stimulation of taurocholate efflux from the rat hepatocyte and the ex vivo perfused rat liver.
- Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.
- Cholesterol and bile acid metabolism in cultures of primary rat bile ductular epithelial cells.
- Bile salts in submicellar concentrations promote bidirectional cholesterol transfer (exchange) as a function of their hydrophobicity.
- Simultaneous measurement of cholesterol 7 alpha-hydroxylase activity by reverse-phase high-performance liquid chromatography using both endogenous and exogenous [4-14C...
- Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions.
- Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid s...
- Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.
- Regulation of bile acid synthesis. I. Effects of conjugated ursodeoxycholate and cholate on bile acid synthesis in chronic bile fistula rat.
- Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rat.
- Medical therapy of Gallstones: state of the art.
- Effects of ursodeoxycholic acid, analogues of ursodeoxycholic acid and combination of bile acids on bile acid synthesis in cultured rat hepatocytes.
- Endoscopic treatment of biliary tract Disease.
- Endoscopic laser therapy for GI Diseases.
- Immunochemical evidence for induction of a common form of hepatic cytochrome P-450 in rats treated with pregnenolone-16 alpha-carbonitrile or other steroidal or non-st...
- Failure of intravenous infusion of taurocholate to down-regulate cholesterol 7 alpha-hydroxylase in rats with biliary fistulas.
- Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in rats with subtotal nephrectomy.
- Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7 alpha-hydroxylase.
- Choledocholithiasis Without Cholelithiasis: Should the Gallbladder Stay or Should It Go?
Schools
University of Massachusetts Worcester Campus
Med College Va
Ohio State University
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
Conditions Treated
- Anemia
- Cholecystitis and Gallstones
- Colorectal Cancer
- Diaphragmatic and-or Hiatal Hernia
- View All
Doctors Specialties
- Gastroenterology
- Transplant Hepatology
Accepted Insurances
Awards
- Fellow (AGAF)
- Fellows
- Fellow (FACG)
Education
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Ohio State University Hospital -
Virginia Commonwealth University Health System -
University of Massachusetts Medical School
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