Professor, Medicine, Boston University School of Medicine
Hematology
Dr. Douglas V. Faller, MD
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Douglas Faller is an expert in the field of Hematology. He researched medicine at Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He received 1 awards: "Elected Member". Douglas V. Faller is a published doctor. He published 101 publications, including: 'Regulation of platelet-derived growth factor signaling by activated p21Ras.' He accepts Medicare.
Publications
- SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27.
- Identification of a novel polyprenylated acylphloroglucinolâderived SIRT1 inhibitor with cancerâspecific anti-proliferative and invasion-suppressing activities.
- Targeted Fetal Hemoglobin Induction for Treatment of Beta Hemoglobinopathies.
- Protein Kinase Cδ Is a Therapeutic Target in Malignant Melanoma with NRAS Mutation.
- MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic cancer Cells by increasing SOCS3 expression.
- Enhanced Cytotoxicity from Deoxyguanosine-Enriched T-oligo in Prostate Cancer Cells.
- Telomere-Homologous G-Rich Oligonucleotides Sensitize Human Ovarian Cancer Cells to TRAIL-Induced Growth Inhibition and Apoptosis.
- SIRT1 enhances matrix metalloproteinase-2 expression and tumor Cell invasion in prostate cancer Cells.
- Targeting the RAS oncogene.
- SIRT1 represses estrogen-signaling, ligand-independent ER?-mediated transcription, and Cell proliferation in estrogen-responsive breast Cells.
- Butyrate histone deacetylase inhibitors.
- SIRTUIN (SIRT) 1 AND STEROID HORMONE RECEPTOR ACTIVITY IN CANCER.
- Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize Lymphoma cells to nucleoside anti-viral agents.
- Protein kinase C-delta inactivation inhibits Cellular proliferation and decreases survival in human neuroendocrine tumors.
- Retraction. HIC1 regulates tumor Cell responses to endocrine therapies.
- Mechanism of T-oligo-induced Cell cycle arrest in Mia-Paca pancreatic cancer Cells.
- Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo.
- Evaluation of Safety and Pharmacokinetics of Sodium 2,2 Dimethylbutyrate, a Novel Short Chain Fatty Acid Derivative, in a Phase 1, Double-Blind, Placebo-Controlled, Si...
- T-oligos inhibit growth and induce apoptosis in human ovarian cancer Cells.
- A vitamin D receptor-alkylating derivative of 1α,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer Cells and suppresses tumor growth.
- Fetal globin gene inducers: novel agents and new potential.
- HIC1 regulates tumor Cell responses to endocrine therapies.
- Development of a malignancy-associated proteomic signature for diffuse large B-cell Lymphoma.
- Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid Cells: mechanism and therapeutic potential.
- Drosophila female sterile (1) homeotic is a multifunctional transcriptional regulator that is modulated by Ras signaling.
- Aberrant activation of gamma-catenin promotes genomic instability and oncogenic effects during tumor progression.
- Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor.
- Protein kinase C delta is required for survival of Cells expressing activated p21RAS.
- A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies.
- Medical hyperspectral imaging to facilitate residual tumor identification during surgery.
- Tumor-specific and proliferation-specific gene expression typifies murine transgenic B cell Lymphomagenesis.
- Short, discontinuous exposure to butyrate effectively sensitizes latently EBV-infected Lymphoma cells to nucleoside analogue antiviral agents.
- Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex.
- Identification of transcription complexes that contain the double bromodomain protein Brd2 and chromatin remodeling machines.
- Fas ligand-mediated lethal hepatitis after rapid lysis of a localized natural killer cell Lymphoma.
- Leukemia virus long terminal repeat activates NFkappaB pathway by a TLR3-dependent mechanism.
- Enhancement of growth and survival and alterations in Bcl-family proteins in beta-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives.
- Histone deacetylase inhibition-mediated post-translational elevation of p27KIP1 protein levels is required for G1 arrest in fibroblasts.
- E mu-BRD2 transgenic mice develop B-cell lymphoma and Leukemia.
- Characterization of p21Ras-mediated apoptosis induced by protein kinase C inhibition and application to human tumor Cell lines.
- Mutations that abrogate transactivational activity of the feline Leukemia virus long terminal repeat do not affect virus replication.
- Alpha-lipoic acid induces p27Kip-dependent Cell cycle arrest in non-transformed Cell lines and apoptosis in tumor Cell lines.
- Bcl-2, via its BH4 domain, blocks apoptotic signaling mediated by mitochondrial Ras.
- Short-chain fatty acid derivatives induce fetal globin expression and erythropoiesis in vivo.
- Epstein-Barr virus latent membrane protein-1 induction by histone deacetylase inhibitors mediates induction of interCellular adhesion molecule-1 expression and homotyp...
- Desensitization of the PDGFbeta receptor by modulation of the cytoskeleton: the role of p21(Ras) and Rho family GTPases.
- Differential effects of short-chain fatty acids on head and neck squamous carcinoma Cells.
- Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.
- Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem Cells in culture and in vivo.
- Human placental membrane vesicles as models for investigation of cystic fibrosis.
- Factors affecting chloride conductance in apical membrane vesicles from human placenta.
- Normalization of DNA-microarray data by nonlinear correlation maximization.
- High-throughput evaluation of olefin copolymer composition by means of attenuated total reflection Fourier tranform infrared spectroscopy.
- Induction of the Epstein-Barr virus thymidine kinase gene with concomitant nucleoside antivirals as a therapeutic strategy for Epstein-Barr virus-associated malignancies.
- Epstein--Barr virus post-transplant lymphoproliferative Disease and virus-specific therapy: pharmacological re-activation of viral target genes with arginine butyrate.
- You bet-cha: a novel family of transcriptional regulators.
- The recruitment of Fas-associated death domain/caspase-8 in Ras-induced apoptosis.
- Redox control of retinoic acid receptor activity: a novel mechanism for retinoic acid resistance in melanoma Cells.
- Short-chain fatty acid derivatives stimulate Cell proliferation and induce STAT-5 activation.
- Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid Cell adhesion in vitro.
- Long terminal repeat regions from exogenous but not endogenous feline Leukemia viruses transactivate cellular gene expression.
- Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species.
- RING3 kinase transactivates promoters of Cell cycle regulatory genes through E2F.
- Activation-induced nuclear translocation of RING3.
- DNA-damaging aryl hydrocarbons induce Mdm2 expression via p53-independent post-transcriptional mechanisms.
- Hypoxia affects tumor Cell invasiveness in vitro: the role of hypoxia-activated ligand HAL1/13 (Ku86 autoantigen).
- A novel DNA damage checkpoint involving post-transcriptional regulation of cyclin A expression.
- Selective inhibition of protein kinase C isozymes by Fas ligation.
- Feline Leukemia virus long terminal repeat activates collagenase IV gene expression through AP-1.
- Establishment of order in the flow of genetic information in Cells.
- Sustained induction of fetal hemoglobin by pulse butyrate therapy in Sickle cell disease.
- Endothelial Cell responses to hypoxic stress.
- Regulation of platelet-derived growth factor signaling by activated p21Ras.
- Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial Cells.
- Correlation of genetic instability and apoptosis in the presence of oncogenic Ki-Ras.
- Alterations in protein-DNA interactions in the gamma-globin gene promoter in response to butyrate therapy.
- Cellular and molecular effects of a pulse butyrate regimen and new inducers of globin gene expression and hematopoiesis.
- Butyrate-induced G1 arrest results from p21-independent disruption of retinoblastoma protein-mediated signals.
- Differential regulation of discrete apoptotic pathways by Ras.
- Arginine butyrate-induced susceptibility to ganciclovir in an Epstein-Barr-virus-associated Lymphoma.
- Abrogation of IL-3 requirements and stimulation of hematopoietic Cell proliferation in vitro and in vivo by carboxylic acids.
- Butyrate in the treatment of Sickle cell disease and beta-thalassemia.
- Moloney murine Leukemia virus long terminal repeat activates monocyte chemotactic protein-1 protein expression and chemotactic activity.
- Regulation of c-jun gene expression in endothelial Cells by the protein kinase inhibitor staurosporine.
- Protection from apoptosis in human neutrophils is determined by the surface of adhesion.
- Microsatellite alterations indicating monoclonality in atypical hyperplasias associated with breast cancer.
- Activation of collagenase IV gene expression and enzymatic activity by the Moloney murine Leukemia virus long terminal repeat.
- A benzo[a]pyrene-induced Cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts.
- Identification of a cis-acting element in the class I major histocompatibility complex gene promoter responsive to activation by retroviral sequences.
- Erythroid progenitor proliferation is stimulated by phenoxyacetic and phenylalkyl acids.
- Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras.
- Dose-intensive melphalan with blood stem Cell support for the treatment of AL amyloidosis: one-year follow-up in five patients.
- Expression of the aryl hydrocarbon receptor is regulated by serum and mitogenic growth factors in murine 3T3 fibroblasts.
- Detection of monoclonal microsatellite alterations in atypical breast hyperplasia.
- Immunoblastic Lymphoma of donor origin in the allograft after lung transplantation.
- Down-regulation of platelet-derived growth factor receptor expression during terminal differentiation of 3T3-L1 pre-adipocyte fibroblasts.
- Hypoxia decreases constitutive nitric oxide synthase transcript and protein in cultured endothelial Cells.
- A role for activated p21 ras in inhibition/regulation of platelet-derived growth factor (PDGF) type-beta receptor activation.
- Moloney murine Leukemia virus activates NF-kappa B.
- 13-cis-retinoic acid with alpha-2a-interferon enhances radiation cytotoxicity in head and neck squamous Cell carcinoma in vitro.
Schools
Harvard Medical School
Uc San Francisco Hosps
Brigham and Women39s Hospital
Conditions Treated
- Acute Leukemia
- Anemia
- Antiphospholipid Syndrome (APS)
- Coagulation Disorders (incl. Hemophilia)
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Doctors Specialties
- Hematology
Accepted Insurances
Awards
- Elected Member
Education
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UCSF -
Harvard Medical School
Hospital
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Boston Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1285699439 |
| Last Name Of The Provider | FALLER |
| First Name Of The Provider | DOUGLAS |
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