Adjunct Professor, Physiology, University of Maryland School of Medicine
Cardiology
Dr. Edward G. Lakatta, MD
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Edward Lakatta is an expert in the field of Cardiology. He graduated from Georgetown University School of Medicine. Georgetown University School of Medicine is ranked 49/84 in Research/PrimaryCare. He over the years received 1 awards: "Elected Member". Edward Lakatta is a published doctor. He published 99 publications, including: 'Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Yaniv. Kinetics of PKA acti...'
Publications
- Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Yaniv. Kinetics of PKA acti...
- The conundrum of arterial stiffness, elevated blood pressure, and aging.
- Vessel Ultrasound Sonographic Assessment of Soluble Receptor for Advanced Glycation End Products Efficacy in a Rat Balloon Injury Model.
- Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.
- Are personality traits associated with white-coat and masked hypertension?
- Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells.
- Prevalence, Clinical Correlates, and Functional Impact of Subaortic Ventricular Septal Bulge (from the Baltimore Longitudinal Study of Aging).
- Longitudinal Perspective on the Conundrum of Central Arterial Stiffness, Blood Pressure, and Aging.
- Role of bone mineral density in the inverse relationship between body size and aortic calcification: Results from the Baltimore Longitudinal Study of Aging.
- Gene-Age Interactions in Blood Pressure Regulation: A Large-Scale Investigation with the CHARGE, Global BPgen, and ICBP Consortia.
- Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
- Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells.
- Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates.
- Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals.
- Impact of Central Obesity on the Estimation of Carotid-Femoral Pulse Wave Velocity.
- GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells.
- Personality Traits and Circadian Blood Pressure Patterns: A 7-Year Prospective Study.
- The N-glycoform of sRAGE is the key determinant for its therapeutic efficacy to attenuate injury-elicited arterial inflammation and neointimal growth.
- Proinflammation: the key to arterial aging.
- Sarcoplasmic reticulum Ca(2+) cycling protein phosphorylation in a physiologic Ca(2+) milieu unleashes a high-power, rhythmic Ca(2+) clock in ventricular myocytes: Rel...
- Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging.
- The relationship between brain-heart autonomic signaling and aging: a gender-specific longitudinal perspective from the Baltimore longitudinal study on aging.
- Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca²âº cycling dynamics.
- Early contribution of arterial wave reflection to left ventricular relaxation abnormalities in a community-dwelling population of normotensive and untreated hypertensi...
- Can proteomics yield insight into aging aorta?
- Dietary Sodium Restriction and Association with Urinary Marinobufagenin, Blood Pressure, and Aortic Stiffness.
- Prevalence and Prognostic Significance of Exercise-Induced Nonsustained Ventricular Tachycardia in Asymptomatic Volunteers: BLSA (Baltimore Longitudinal Study of Aging).
- Pacemaker Gene Mutations, Bradycardia, Arrhythmias and the Coupled Clock Theory.
- The relationship between visceral adiposity and left ventricular diastolic function: Results from the Baltimore Longitudinal Study of Aging.
- The reality of aging viewed from the arterial wall.
- EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy.
- Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulat...
- New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression o...
- Ca(2+)/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity and Sinoatrial Nodal Pacemaker Cell Energetics.
- Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac ...
- Ca2+-dependent phosphorylation of Ca2+ cycling proteins generates robust rhythmic local Ca2+ releases in cardiac pacemaker cells.
- Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis.
- Reprogramming paces the heart.
- Association of Arterial Rigidity with Incident Kidney Disease and Kidney Function Decline: The Health ABC Study.
- Impact of T2 decay on carotid artery wall thickness measurements.
- RGS2 overexpression or G(i) inhibition rescues the impaired PKA signaling and slow AP firing of cultured adult rabbit pacemaker cells.
- Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.
- Acute hemodynamic effects of erythropoietin do not mediate its cardioprotective properties.
- The burden of obesity on blood pressure is reduced in older persons: The Sardinia study.
- Age-associated increase in salt sensitivity is accompanied by a shift in the atrial natriuretic peptide modulation of the effect of marinobufagenin on renal and vascul...
- The "Funny" Current (If) Inhibition by Ivabradine at Membrane Potentials Encompassing Spontaneous Depolarization in Pacemaker Cells.
- Arterial Stiffness and Vitamin D Levels: the Baltimore Longitudinal Study of Aging.
- Crosstalk between Mitochondrial and Sarcoplasmic Reticulum Ca(2+) Cycling Modulates Cardiac Pacemaker Cell Automaticity.
- MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling.
- Did clinical trials in which erythropoietin failed to reduce acute myocardial infarct size miss a narrow therapeutic window?
- Linkage of Cardiac Gene Expression Profiles and ETS2 with Lifespan Variability in Rats.
- Contribution of Central Adiposity to Left Ventricular Diastolic Function (from the Baltimore Longitudinal Study of Aging).
- Age-Associated Proinflammatory Secretory Phenotype in Vascular Smooth Muscle Cells From the Non-human Primate Macaca mulatta: Reversal by Resveratrol Treatment.
- Aging-associated cardiovascular changes and their relationship to heart failure.
- Gi-Biased ?2AR Signaling Links GRK2 Upregulation to Heart Failure.
- Associations of large artery structure and function with adiposity: Effects of age, gender, and hypertension. The SardiNIA Study.
- On the shape of the common carotid artery with implications for blood velocity profiles.
- Use of the Frank-Starling Mechanism during Exercise is Linked to Exercise-Induced Changes in Arterial Load.
- The funny current in the context of the coupled clock pacemaker cell system.
- What I(f) the shoe doesn't fit? Rebuttal to DiFrancesco and Noble "The funny current has a major pacemaking role in the sinus node"
- Beat-to-beat Ca(2+)-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm.
- A full range of mouse sinoatrial node AP firing rates requires protein kinase A-dependent calcium signaling.
- Ca(2+)-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand.
- Association of central hemodynamics with estimated 24-h urinary sodium in patients with hypertension.
- Letter to the editor: "Validating the requirement for beat-to-beat coupling of the Ca2+ clock and M clock in pacemaker cell normal automaticity".
- A bioluminescence method for direct measurement of phosphodiesterase activity.
- Age-Associated Vascular Oxidative Stress, Nrf2 Dysfunction, and NF-{kappa}B Activation in the Nonhuman Primate Macaca mulatta.
- Effects of calorie restriction on cardioprotection and cardiovascular health.
- Abnormalities in arterial-ventricular coupling in older healthy persons are attenuated by sodium nitroprusside.
- NF-κB inhibition compromises cardiac fibroblast viability under hypoxia.
- A small nonerythropoietic helix B surface peptide based upon erythropoietin structure is cardioprotective against ischemic myocardial damage.
- Synchronization of stochastic Ca²(+) release units creates a rhythmic Ca²(+) clock in cardiac pacemaker cells.
- Ca cycling in heart cells from ground squirrels: adaptive strategies for intracellular ca homeostasis.
- A local proinflammatory signalling loop facilitates adverse age-associated arterial remodeling.
- Effect of common carotid artery inlet length on normal carotid bifurcation hemodynamics.
- Central Arterial Aging and Angiotensin II Signaling.
- Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial.
- β(2) AR Agonists in Treatment of Chronic Heart Failure: Long Path to Translation.
- A vascular theory of aging.
- Race, psychosocial factors, and aortic pulse wave velocity: the Health, Aging, and Body Composition Study.
- Chronic alternate-day fasting results in reduced diastolic compliance and diminished systolic reserve in rats.
- Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as men.
- Sarcoplasmic reticulum Ca2+ pumping kinetics regulates timing of local Ca2+ releases and spontaneous beating rate of rabbit sinoatrial node pacemaker cells.
- Modulation of sarcoplasmic reticulum Ca(2+) cycling in systolic and diastolic heart failure associated with aging.
- Carotid bifurcation hemodynamics in older adults: effect of measured versus assumed flow waveform.
- Physiologic gating properties of unitary cardiac L-type Ca2+ channels.
- A novel quantitative explanation for the autonomic modulation of cardiac pacemaker cell automaticity via a dynamic system of sarcolemmal and intracellular proteins.
- Elevated mineralocorticoid receptor activity in aged rat vascular smooth muscle cells promotes a proinflammatory phenotype via extracellular signal-regulated kinase 1/...
- A paradigm shift for the heart's pacemaker.
- A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.
- Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study.
- Matching ATP supply and demand in mammalian heart: in vivo, in vitro, and in silico perspectives.
- Yin and yang of the cardiac pacemaker clock system in health and disease.
- Commentaries on viewpoint: The cardiac contraction cycle: is Ca2+ going local? Counterpoint.
- Beta-adrenergic signaling accelerates and synchronizes cardiac ryanodine receptor response to a single L-type Ca2+ channel.
- Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exc...
- Role of body size on cardiovascular function: can we see the meat through the fat?
- Cholinergic receptor signaling modulates spontaneous firing of sinoatrial nodal cells via integrated effects on PKA-dependent Ca(2+) cycling and I(KACh).
Schools
Georgetown University
Strong Memorial Hospital
Georgetown University Hospital
Johns Hopkins School Med
University College
Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Elected Member
Education
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Johns Hopkins University -
Georgetown University Hospital -
University of Rochester -
Georgetown University School of Medicine
Hospital
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University of Maryland Medical Center
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