Professor, Pathology and Immunology, Washington University School of Medicine

Pathology

Dr. Erika C. Crouch works in the field of Pathology. She has 1 awards "Elected Member". Doctor Erika C. Crouch, MD is also a published doctor. She has 40 paper published. The most recent paper is: OSCAR Is a Receptor for Surfactant Protein D That Activates TNF- Release from Human CCR2+ Inflammatory Monocytes. Erika Crouch accepts all Medicare patients.

Publications

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• OSCAR Is a Receptor for Surfactant Protein D That Activates TNF-α Release from Human CCR2+ Inflammatory Monocytes.
• Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses.
• Molecular mechanisms of inhibition of influenza by surfactant protein d revealed by large-scale molecular dynamics simulation.
• The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins.
• The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding.
• Pandemic H1N1 influenza A viruses are resistant to the antiviral activities of innate immune proteins of the collectin and pentraxin superfamilies.
• Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D.
• Surfactant protein D-mediated decrease of allergen-induced inflammation is dependent upon CTLA4.
• Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo.
• Viral aggregating and opsonizing activity in collectin trimers.
• Review: Structural determinants of pattern recognition by lung collectins.
• Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.
• Lung environment determines unique phenotype of alveolar macrophages.
• Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo.
• Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus.
• Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease.
• Antiviral activity of the long chain pentraxin PTX3 against influenza viruses.
• Impact of neutrophils on antiviral activity of human bronchoalveolar lavage fluid.
• Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses.
• Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophages.
• Effect of lung surfactant collectins on bronchoalveolar macrophage interaction with Blastomyces dermatitidis: inhibition of tumor necrosis factor alpha production by s...
• Species differences in the carbohydrate binding preferences of surfactant protein D.
• Identification and characterization of endogenous Langerin ligands in murine extracellular matrix.
• Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D.
• Mycobacterium tuberculosis binding to human surfactant proteins A and D, fibronectin, and small airway epithelial cells under shear conditions.
• Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation.
• IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response.
• A role for surfactant protein D in innate immunity of the human prostate.
• Surfactant protein D decreases pollen-induced IgE-dependent mast cell degranulation.
• Surfactant proteins A and D enhance the phagocytosis of Chlamydia into THP-1 cells.
• Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
• Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs.
• Interactions of surfactant protein D with fatty acids.
• Porcine pulmonary collectins show distinct interactions with influenza A viruses: role of the N-linked oligosaccharides in the carbohydrate recognition domain.
• Surfactant protein D-mediated aggregation of Pneumocystis carinii impairs phagocytosis by alveolar macrophages.
• Surfactant protein A and D differently regulate the immune response to nonmucoid Pseudomonas aeruginosa and its lipopolysaccharide.
• Contributions of the N- and C-terminal domains of surfactant protein d to the binding, aggregation, and phagocytic uptake of bacteria.
• Trimerization of the amino propeptide of type IIA procollagen using a 14-amino acid sequence derived from the coiled-coil neck domain of surfactant protein D.
• Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein.

Schools

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• University of Washington

Doctors Specialties

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• Anatomic Pathology
• Pathology

Accepted Insurances

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Awards

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• Elected Member

Education

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• University of Washington

Hospital

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• Barnes-Jewish Hospital

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1912923145
Last Name Of The Provider	CROUCH
First Name Of The Provider	ERIKA
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