Karlson and Karlson Professor of Cardiothoracic Surgery, Brown University
Thoracic Surgery
Dr. Frank W. Sellke, MD
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Frank Sellke is an expert in the field of Thoracic Surgery. He went to Indiana University School of Medicine. Indiana University School of Medicine has a rank of 45 in research and a 47 in primary care He over the years received 12 awards: "Member", "America's Top Doctors", "Distinguished Alumni Award", "Distinguished Achievement Award", "Boston Magazine", "Boston Herald", "Top Cardiothoracic Surgeon", "Whos Who in Medicine and Healthcare", "Fellow (FACC)", "Fellow (FACS)", "Fellow [FACC]" and "Fellow". Frank W. Sellke is also a published physician. He has 98 paper published. The most recent paper is: Alcohol and the Heart: A Proteomics Analysis of Pericardium and Myocardium in a Swine Model of Myocardial Ischemia. Frank Sellke is registered with Medicare and accepts Medicare payments.
Publications
- Differential impairment of adherens-junction expression/phosphorylation after cardioplegia in diabetic versus non-diabetic patients.
- Alcohol and the Heart: A Proteomics Analysis of Pericardium and Myocardium in a Swine Model of Myocardial Ischemia.
- CardioPulmonary Bypass Decreases Activation of the Signal Transducer and Activator of Transcription 3 (STAT3) Pathway in Diabetic Human Myocardium.
- New continuous-flow total artificial Heart and vascular permeability.
- Ca(2+)-activated k(+) channels as therapeutic targets for Myocardial and vascular protection.
- Investigating the effects of resveratrol on chronically ischemic myocardium in a Swine model of metabolic Syndrome: a proteomics analysis.
- Rottlerin-Induced BKCa Channel Activation Impairs Specific Contractile Responses and Promotes Vasodilation.
- Atorvastatin Regulates Apoptosis in Chronically Ischemic Myocardium.
- Oxidative Stress and Nerve Function After CardioPulmonary Bypass in Patients With Diabetes.
- Dabigatran-related coagulopathy: when can we assume the effect has "worn off"?
- Metformin mitigates apoptosis in ischemic myocardium.
- Ethanol promotes new vessel growth in remote nonischemic myocardium.
- Safe Application of a Restrictive Transfusion Protocol in Moderate-Risk Patients Undergoing Cardiac Operations.
- Rapamycin Treatment of Healthy Pigs Subjected to Acute Myocardial Ischemia-Reperfusion Injury Attenuates Cardiac Functions and Increases Myocardial Necrosis.
- Altered expression and activation of mitogen-activated protein kinases in diabetic Heart during cardioplegic arrest and cardiopulmonary bypass.
- Local infiltration of neuropeptide Y as a potential therapeutic agent against apoptosis and fibrosis in a swine model of hypercholesterolemia and chronic Myocardial is...
- Ethanol promotes arteriogenesis and restores perfusion to chronically ischemic myocardium.
- Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes mellitus.
- Oxidative stress improves Coronary endothelial function through activation of the pro-survival kinase AMPK.
- The influence of seasons and lunar cycle on hospital outcomes following ascending aortic Dissection repair.
- The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular Disease.
- Mechanism for reduced Pericardial adhesion formation in hypercholesterolemic swine supplemented with alcohol.
- Does resveratrol improve insulin signaling in chronically ischemic myocardium?
- Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens.
- Metformin alters the insulin signaling pathway in ischemic cardiac tissue in a swine model of metabolic Syndrome.
- Midterm outcomes of patients undergoing aortic valve replacement after previous Coronary artery bypass grafting.
- Effects of red wine and vodka on collateral-dependent perfusion and cardiovascular function in hypercholesterolemic swine.
- Decreased Coronary microvascular reactivity after cardioplegic arrest in patients with uncontrolled diabetes mellitus.
- Cardioprotective effects of red wine and vodka in a model of endothelial dysfunction.
- Essential roles of Raf/ERK/MAPK pathway, YY1, and Ca+2 influx in the growth arrest of human vascular smooth muscle cells by bilirubin.
- Clinically Relevant Extracellular-Matrix Scaffolds for Cell Transplantation and Vascular Repair.
- Regenerative Therapies for Improving Myocardial Perfusion in Patients with Cardiovascular Disease: Failure to Meet Expectations but Optimism for the Future.
- Effects of alcohol on Pericardial adhesion formation in hypercholesterolemic swine.
- Effects of gender and ethnicity on outcomes after Aortic valve replacement.
- Erratum to: Resveratrol in the Prevention and Treatment of Coronary Artery Disease.
- Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia.
- Rottlerin Increases Cardiac Contractile Performance and Coronary Perfusion Through BKCa++ Channel Activation After Cold Cardioplegic Arrest in Isolated Hearts.
- Hypercholesterolemia and chronic ischemia alter Myocardial responses to selective cyclooxygenase-2 inhibition.
- High-fat diet alters prostanoid balance and perfusion in ischemic myocardium of naproxen-treated swine.
- Resveratrol in the prevention and treatment of Coronary artery disease.
- Impaired contractile response of human peripheral arterioles to thromboxane A-2 after cardioPulmonary bypass.
- Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after Acute myocardial ischemia/reperfusion.
- Resveratrol supplementation abrogates pro-arteriogenic effects of intraMyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic i...
- Therapeutic neovascularization for Coronary disease: current state and future prospects.
- p38 MAPK-dependent small HSP27 and {alpha}B-crystallin phosphorylation in regulation of Myocardial function following cardioplegic arrest.
- Improving glucose metabolism with resveratrol in a swine model of metabolic Syndrome through alteration of signaling pathways in the liver and skeletal muscle.
- Chronic type II diabetes mellitus leads to changes in neuropeptide Y receptor expression and distribution in human Myocardial tissue.
- In vitro and in vivo degradation of poly(D, L-lactide-co-glycolide)/amorphous calcium phosphate copolymer coated on metal stents.
- Massive cardiac fibroma.
- Trans-iliac rat Aorta stenting: a novel high throughput preclinical stent model for restenosis and thrombosis.
- Decreased contractile response to endothelin-1 of peripheral microvasculature from diabetic patients.
- Autologous cardiomyotissue implantation promotes Myocardial regeneration, decreases infarct size, and improves left ventricular function.
- Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on Myocardial function and perfusion.
- Is hyperglycemia bad for the Heart during acute ischemia?
- The future of regenerating the myocardium.
- Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium.
- Effects of Selective Cyclooxygenase-2 and Non-Selective COX Inhibition on Myocardial Function and Perfusion.
- Temporal and spatial changes in collateral formation and function during chronic Myocardial ischemia.
- Effect of thrombin fragment (TP508) on Myocardial ischemia reperfusion injury in a model of type 1 diabetes mellitus.
- Effects of cardioPulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation.
- Resveratrol improves Myocardial perfusion in a swine model of hypercholesterolemia and chronic Myocardial ischemia.
- Effects of diabetes mellitus on VEGF-induced proliferation response in bone marrow derived endothelial progenitor cells.
- Endothelium-dependent Coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species.
- Effect of dimerized thrombin fragment TP508 on Acute myocardial ischemia reperfusion injury in hypercholesterolemic swine.
- Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic Syndrome.
- Endothelin-1-induced contractile responses of human Coronary arterioles via endothelin-A receptors and PKC-alpha signaling pathways.
- Altered Coronary microvascular serotonin receptor expression after Coronary artery bypass grafting with cardiopulmonary bypass.
- Gastrointestinal complications following cardiac surgery: a comprehensive review.
- Impairment of human cell-based vasculogenesis in rats by hypercholesterolemia-induced endothelial dysfunction and rescue with L-arginine supplementation.
- Hyperglycemia attenuates angiogenic capability of survivin in endothelial cells.
- Aprotinin attenuates genomic expression variability following cardiac surgery.
- Large conductance calcium-activated potassium channels contribute to the reduced myogenic tone of peripheral microvasculature after cardioPulmonary bypass.
- Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of Myocardial ischemia/reperfusion injury.
- Effect of hydrogen sulfide in a porcine model of Myocardial ischemia-reperfusion: comparison of different administration regimens and characterization of the cellular ...
- Effect of hypercholesterolemia on Myocardial necrosis and apoptosis in the setting of ischemia-reperfusion.
- Therapeutic angiogenesis in diabetes and hypercholesterolemia: influence of oxidative stress.
- Increased vascular permeability after cardioPulmonary bypass in patients with diabetes is associated with increased expression of vascular endothelial growth factor an...
- Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling.
- Effect of thrombin fragment (TP508) on Myocardial ischemia-reperfusion injury in hypercholesterolemic pigs.
- Metallothionein link to bicuspid Aortic valve-associated ascending Aortic dilatation.
- Thrombin fragment (TP508) decreases Myocardial infarction and apoptosis after ischemia reperfusion injury.
- Endostatin and angiostatin are increased in diabetic patients with Coronary artery disease and associated with impaired Coronary collateral formation.
- Impaired Coronary microvascular dilation correlates with enhanced vascular smooth muscle MLC phosphorylation in diabetes.
- Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery.
- Vascular changes after cardiac surgery: role of NOS, COX, kinases, and growth factors.
- Post-cardiac arrest Syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscit...
- Post-cardiac arrest Syndrome: epidemiology, pathophysiology, treatment, and prognostication. A Scientific Statement from the International Liaison Committee on Resusci...
- Calcium-activated potassium channels contribute to human Coronary microvascular dysfunction after cardioplegic arrest.
- Pilot proteomic profile of differentially regulated proteins in right Atrial appendage before and after cardiac surgery using cardioplegia and cardiopulmonary bypass.
- Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardioPulmonary bypass.
- Atorvastatin increases Myocardial indices of oxidative stress in a porcine model of hypercholesterolemia and chronic ischemia.
- Increased antiangiogenic protein expression in the skeletal muscle of diabetic swine and patients.
- Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse Coronary artery disease: the Endothelial Modu...
- Coronary microvascular dysfunction in the setting of chronic ischemia is independent of arginase activity.
- Chemokines are associated with delirium after cardiac surgery.
- Effects of B-type natriuretic peptide (nesiritide) on Coronary epicardial arteries, systemic vasculature and microvessels.
- Atorvastatin impairs the Myocardial angiogenic response to chronic ischemia in normocholesterolemic swine.
Schools
Indiana University School Of Medicine
Akron City Hospital
University Ia Hosps Clins
Wabash College
Procedures Preformed
- Aneurysm Surgery
- Aortic Aneurysm Repair
- Aortic Repair, Open or Repair of Arterial Aneurysm, Open
- Cardiac Catheterization (incl. Coronary Angiography)
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Conditions Treated
- Aneurysm and Dissection of Heart
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
- Aortic Dissection
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Doctors Specialties
- Cardiac Surgery
- Thoracic Surgery
Accepted Insurances
Awards
- Member
- America's Top Doctors
- Distinguished Alumni Award
- Distinguished Achievement Award
- Boston Magazine
- Boston Herald
- Top Cardiothoracic Surgeon
- Whos Who in Medicine and Healthcare
- Fellow (FACC)
- Fellow (FACS)
- Fellow [FACC]
- Fellow
Education
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University of Iowa Hospitals and Clinics -
Indiana University School of Medicine
Hospital
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Rhode Island Hospital -
Beth Israel Deaconess Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1457304859 |
| Last Name Of The Provider | SELLKE |
| First Name Of The Provider | FRANK |
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