Physician
Pathology
Dr. Frederick L. Kiechle, MD
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Dr. Frederick L. Kiechle works in the field of Pathology. He researched medicine at Indiana University School of Medicine. Indiana University School of Medicine is ranked 45/47 in Research/PrimaryCare. Frederick L. Kiechle is a published MD as well. He has 101 publications published. The latest was: Hoechst 33342 induces apoptosis and alters tata box binding protein/DNA complexes in nuclei from BC3H-1 myocytes. He accepts Medicare.
Publications
- Establishing benchmarks and metrics for disruptive technologies, inappropriate and obsolete tests in the clinical laboratory.
- Multicenter Evaluation of the LightCycler MRSA Advanced Test, the Xpert MRSA Assay, and MRSASelect Directly Plated Culture with Simulated Workflow Comparison for the D...
- Point-of-care testing and molecular diagnostics: miniaturization required.
- Provider-performed microscopy.
- Check Sample Abstracts.
- Molecular pathology: future issues.
- Fatty acid synthase and its mRNA concentrations are decreased at different times following Hoechst 33342-induced apoptosis in BC3H-1 myocytes.
- The -omics era and its impact.
- Effect of polymorphisms in the cytochrome P450 CYP2C9 gene on warfarin anticoagulation.
- Cytosine arabinoside substitution decreases transcription factor-DNA binding element complex formation.
- Review: Glycosphingolipids in health and disease.
- Mitochondrial membrane potential change induced by Hoechst 33342 in myelogenous leukemia cell line HL-60.
- Hoechst 33342 alters luciferase gene expression in transfected BC3H-1 myocytes.
- Genomics, transcriptomics, proteomics, and numbers.
- The postgenomic era: implications for the clinical laboratory.
- Nitric oxide measurements during endotoxemia.
- Hoechst 33342-induced apoptosis is associated with decreased immunoreactive topoisomerase I and topoisomerase I-DNA complex formation.
- Hoechst 33342 induces apoptosis in HL-60 cells and inhibits topoisomerase I in vivo.
- In situ measurement of nitric oxide, superoxide and peroxynitrite during endotoxemia.
- Erythrocyte sedimentation rate.
- Carbon-fiber ultramicroelectrodes modified with conductive polymeric tetrakis(3-methoxy-4-hydroxyphenyl)porphyrin for determination of nickel in single biological cells.
- Oxidation of nitric oxide by oxygen in biological systems monitored by porphyrinic sensor.
- The erythrocyte sedimentation rate and chronic renal failure.
- Increased PO2 measured in a patient with type II cryoglobulinemia.
- Insulin and adenosine regulate the phosphatidylcholine concentration in isolated rat adipocyte plasma membranes.
- Membrane potential of rat adipocytes: effect of phospholipase C, concanavalin A, and adenosine.
- Nitric oxide. Biochemistry, pathophysiology, and detection.
- Production of lactate by aerobic bacteria.
- Partial purification from rat adipocyte plasma membranes of a chemical mediator which simulates the action of insulin on pyruvate dehydrogenase.
- Isolation from rat adipocytes of a chemical mediator for insulin activation of pyruvate dehydrogenase.
- Differences in the effect of insulin on the generation by adipocytes and IM-9 lymphocytes of a chemical mediator which simulates the action of insulin on pyruvate dehy...
- Atheromatous embolization.
- Phospholipids and the regulation of pyruvate dehydrogenase from rat adipocyte mitochondria.
- Lactate production by aerobic bacteria grown in cerebrospinal fluid.
- Use of alkaline phosphatase isoenzyme analysis in the evaluation of cholestatic liver disease.
- Parallel stimulation in adipocytes of the plasma membrane Ca2+-transport/(Ca2+ + Mg2+)-ATPase system and mitochondrial pyruvate dehydrogenase by a supernatant factor d...
- Intracellular mediators of insulin action.
- Insulin stimulation of phospholipid methylation in isolated rat adipocyte plasma membranes.
- The chemical mediators of insulin action: possible targets for postreceptor defects.
- Comparison of phospholipid effects on insulin-sensitive low Km cyclic AMP phosphodiesterase in adipocyte plasma membranes and microsomes.
- Phospholipid modulation of low-Km cyclic AMP phosphodiesterase activity on rat adipocyte microsomes.
- Chemical mediator or mediators of insulin action: response to insulin and mode of action.
- Partial purification from hepatoma cells of an intracellular substance which mediates the effects of insulin on pyruvate dehydrogenase and low Km cyclic AMP phosphodie...
- The effect of an insulin-sensitive chemical mediator from rat adipocytes low Km and high Km cyclic AMP phosphodiesterase.
- Insulin stimulation of pyruvate dehydrogenase in an isolated plasma membrane-mitochondrial mixture occurs by activation of pyruvate dehydrogenase phosphatase.
- Enzyme reagents for measurement of phospholipids of amniotic fluid.
- Comparison of the performance of serum and urine hCG immunoassays in the evaluation of gynecologic patients.
- Factors influencing erythrocyte sedimentation in patients with chronic renal failure.
- Three methods compared for determining phosphatidylglycerol in amniotic fluid.
- Pseudohyponatremia.
- Alkaline phosphatase in the assessment of choledocholithiasis before surgery.
- Biochemical screening in urinalysis.
- Liver function tests and choledocholithiasis.
- Effect of phospholipase C on high-molecular-mass alkaline phosphatase in serum.
- Intramitochondrial inclusions in hepatocytes.
- Primary linitis plastica of the colon and rectum.
- Fluorometric determination of phosphatidylcholine as a measure of phospholipid methylation.
- Fasting induced alterations in mitochondrial palmitoyl-CoA metabolism may inhibit adipocyte pyruvate dehydrogenase activity.
- Quality improvement in the laboratory assessment of in vitro fertilization.
- A flow cytometric method to detect anti-pyruvate dehydrogenase antibody in primary biliary cirrhosis.
- Assessment of mitochondrial function in cells grown in tissue culture.
- Effect of S-adenosylhomocysteine on insulin-independent release of pyruvate dehydrogenase activator from rat adipocyte plasma membranes.
- The clinical use of alkaline phosphatase enzymes.
- Stimulation of phosphatidylcholine synthesis by insulin and ATP in isolated rat adipocyte plasma membranes.
- Effect of insulin, S-adenosylhomocysteine, phospholipase C, n-butanol and Triton X-114 on alkaline phosphatase from isolated rat adipocyte plasma membranes.
- Electrophoresis and the isomune-LD and LD-1 immuno methods compared for measurement of lactate dehydrogenase isoenzyme-1.
- Mannitol interference in an automated serum phosphate assay.
- Association of high-molecular-mass and electrophoretically atypical alkaline phosphatases.
- Phosphatidylglycerol in amniotic fluid. Comparison of an "ultrasensitive" immunologic assay with TLC and enzymatic assay.
- Comparison of agarose gel electrophoresis and a chaotropic method for lactate dehydrogenase isoenzyme-1.
- Dextran interference in biuret-based assays for serum proteins.
- Potential problems in serum protein electrophoresis.
- The effect of amino acids, monoamines and polyamines on pyruvate dehydrogenase activity in mitochondria from rat adipocytes.
- A comparison of chromogen test strip (Chemstrip bG) and serum glucose values in newborns.
- Hoechst 33342-induced apoptosis in BC3H-1 myocytes.
- Specimen stability for DNA-based diagnostic testing.
- Indirect detection of nitric oxide effects: a review.
- Endometriosis: identification by carbonic anhydrase autoantibodies and clinical features.
- Diagnostic molecular pathology in the twenty-first century.
- Counter modulation of adipocyte mitochondrial processes by insulin and S-oxalylglutathione.
- Autoantibodies to specific enzymes: a review.
- Mitochondrial disorders. Methods and specimen selection for diagnostic molecular pathology.
- Specimen collection and storage for diagnostic molecular pathology investigation.
- Lactate oxidation for the detection of mitochondrial dysfunction in human skin fibroblasts.
- Comparison of the HemoCue beta-glucose photometer and reflotron for open heart surgery.
- Residency in pathology. The William Beaumont Hospital perspective.
- Carbonic anhydrase antibody in sera from patients with endometriosis.
- Lactic acidosis and mitochondrial dysfunction in two children with peroxisomal disorders.
- Tyrphostin 47 nonenzymatically decarboxylates [1-14C]-pyruvate.
- Antibodies to carbonic anhydrase in patients with immune cholangiopathies.
- Satellite laboratories. A cost-benefit study.
- Bedside testing, Part 2. Bedside testing: beyond glucose.
- Implementing a successful bedside glucose program.
- The molecular pathology laboratory of the 21st century.
- Hoechst 33342 induces apoptosis and alters tata box binding protein/DNA complexes in nuclei from BC3H-1 myocytes.
- Mechanism of Hoechst 33342-induced apoptosis in BC3H-1 myocytes.
- Multicenter study of oxygen-insensitive handheld glucose point-of-care testing in critical care/hospital/ambulatory patients in the United States and Canada.
- Hoechst 33342-induced apoptosis is associated with intracellular accumulation of E2F-1 protein in BC3H-1 myocytes and HL-60 cells.
- DNA technology, the clinical laboratory, and the future.
- DNA technology in the clinical laboratory.
Schools
Indiana University School of Medicine
William Beaumont Hospital
Barnes Jewish Hospital
Doctors Specialties
- Pathology
Accepted Insurances
- Assurant Health
- AvMed
- CHAMPVA
- Great West Healthcare-Cigna PPO
- Commercial Insurance Company
- CoreSource
- Coventry Health Care
- Emblem Health
- Humana
- Medicaid
- Medicare MCR
- Priority Health
- United Healthcare
Education
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William Beaumont Hospital -
Indiana University School of Medicine
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1962416818 |
| Last Name Of The Provider | KIECHLE |
| First Name Of The Provider | FREDERICK |
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