Professor of Pediatrics, Johns Hopkins University School of Medicine
Endocrinology
Dr. Fredric E. Wondisford, MD
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Fredric Wondisford works in the field of Endocrinology. He went to medical school at Northeast Ohio Medical University. He received awards:"CMS Meaningful Use Stage 1 Certification" and "Elected Member". Fredric Wondisford is also a published doctor. He has 100 paper published. The most recent paper is: A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein.
Publications
- Developmental and endocrine regulation of kisspeptin expression in mouse leydig cells.
- Thyroid hormone receptors and resistance to thyroid hormone disorders.
- Potential biomarker of metformin action.
- Circadian Regulation of Tshb Gene Expression by Rev-Erbα (NR1D1) and Nuclear Corepressor 1 (NCOR1).
- Obesity induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell.
- Both Estrogen Receptor Alpha and Beta Stimulate Pituitary GH Gene Expression.
- Activation of Basal Gluconeogenesis by Coactivator p300 Maintains Hepatic Glycogen Storage.
- CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.
- A new medical therapy for Cushing disease?
- The {Delta}337T mutation on the TR{beta} causes alterations in growth, adiposity and hepatic glucose homeostasis in mice.
- Deletion of otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism.
- Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.
- Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development.
- Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1).
- In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and...
- A thyroid hormone receptor mutation that dissociates thyroid hormone regulation of gene expression in vivo.
- Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.
- Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism.
- Connexin40 messenger ribonucleic acid is positively regulated by thyroid hormone (TH) acting in cardiac atria via the TH receptor.
- Exendin-4 stimulation of cyclin A2 in beta-cell proliferation.
- An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.
- Thyroid hormone action is required for normal cone opsin expression during mouse retinal development.
- TRH testing in its infancy.
- Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation.
- Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.
- Unlikely partners in weight loss?
- Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model.
- The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency.
- Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface.
- An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements.
- Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein.
- Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform.
- Dominant inhibition of thyroid hormone action selectively in the pituitary of thyroid hormone receptor-beta null mice abolishes the regulation of thyrotropin by thyroi...
- Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo.
- Thyroid hormone action: insight from transgenic mouse models.
- Leucine at codon 428 in the ninth heptad of thyroid hormone receptor beta1 is necessary for interactions with the transcriptional cofactors and functions regardless of...
- Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation.
- The thyroid axis just got more complicated.
- Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice.
- CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box.
- The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains.
- A pituitary tumor in a patient with thyroid hormone resistance: a diagnostic dilemma.
- Critical role for thyroid hormone receptor beta2 in the regulation of paraventricular thyrotropin-releasing hormone neurons.
- An unliganded thyroid hormone receptor causes severe neurological dysfunction.
- Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.
- cAMP response element-binding protein-binding protein mediates thyrotropin-releasing hormone signaling on thyrotropin subunit genes.
- The nuclear corepressors recognize distinct nuclear receptor complexes.
- Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor.
- Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators.
- CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression.
- p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers.
- The thyroid hormone receptor-beta gene mutation R383H is associated with isolated central resistance to thyroid hormone.
- Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system.
- Defective retinoic acid regulation of the Pit-1 gene enhancer: a novel mechanism of combined pituitary hormone deficiency.
- A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein.
- Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin.
- Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone.
- Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements.
- The molecular basis of hypopituitarism.
- Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein.
- A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-i...
- Comparison of administration of recombinant human thyrotropin with withdrawal of thyroid hormone for radioactive iodine scanning in patients with thyroid carcinoma.
- Thyrotropin (TSH) beta-subunit gene expression--an example for the complex regulation of pituitary hormone genes.
- Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone.
- Thyroid hormone action beyond the receptor.
- Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain.
- Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin.
- A circulating, biologically inactive thyrotropin caused by a mutation in the beta subunit gene.
- AP-1 antagonizes thyroid hormone receptor action on the thyrotropin beta-subunit gene.
- A "hot spot" in the Pit-1 gene responsible for combined pituitary hormone deficiency: clinical and molecular correlates.
- Ligand-independent and -dependent functions of thyroid hormone receptor isoforms depend upon their distinct amino termini.
- Ligand-dependent antagonism by retinoid X receptors of inhibitory thyroid hormone response elements.
- Steroid hormone regulation and tissue-specific expression of the human GnRH gene in cell culture and transgenic animals.
- The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements.
- Recombinant thyrotropin containing a beta-subunit chimera with the human chorionic gonadotropin-beta carboxy-terminus is biologically active, with a prolonged plasma h...
- A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition.
- Pericarditis associated with Crohn's disease.
- Expression of biologically active bovine luteinizing hormone in Chinese hamster ovary cells.
- Cloning of the human thyrotropin beta-subunit gene and transient expression of biologically active human thyrotropin after gene transfection.
- Tight linkage between the syndrome of generalized thyroid hormone resistance and the human c-erbA beta gene.
- Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon.
- Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis.
- Pre-translational and post-translational regulation of TSH synthesis in normal and neoplastic thyrotrophs.
- Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species.
- Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta.
- Analysis of gonadotropin-releasing hormone gene structure in families with familial central precocious puberty and idiopathic hypogonadotropic hypogonadism.
- Thyroid hormone and DNA binding properties of a mutant c-erbA beta receptor associated with generalized thyroid hormone resistance.
- A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds.
- Cloning and structure of human genomic DNA and hypothalamic cDNA encoding human prepro thyrotropin-releasing hormone.
- Pre-translational and post-translational regulation of TSH: relationship to bioactivity.
- The paraventricular nucleus of the hypothalamus has a major role in thyroid hormone feedback regulation of thyrotropin synthesis and secretion.
- Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.
- Evidence for direct estrogen regulation of the human gonadotropin-releasing hormone gene.
- Thyrotropin-releasing hormone regulation of human TSHB expression: role of a pituitary-specific transcription factor (Pit-1/GHF-1) and potential interaction with a thy...
- Assignment of human preprothyrotropin-releasing hormone (TRH) gene to chromosome 3.
- A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene.
- A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the ...
- Mutations of the human thyrotropin-beta subunit glycosylation site reduce thyrotropin synthesis independent of changes in glycosylation status.
- A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.
Schools
Northeastern Ohio University College of Medicine
University HospsCase Western Res University
National Institute Of Health
Doctors Specialties
- Endocrinology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Select
- Blue Card PPO
- Blue Preferred PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Coventry Health Care of Delaware PPO
- Geisinger Health Plan
- Choice Care PPO
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Options PPO
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
Education
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Case Western Reserve University - University Hospitals -
Northeast Ohio Medical University
Hospital
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Johns Hopkins Hospital -
Robert Wood Johnson University Hospital
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