Professor, Pathology, University of Michigan Medical School

Pathology

Doctor Gabriel Nunez, MD practices Pathology. Gabriel Nunez, MD is a published doctor. He has 39 papers published. The most current publication "Antigen presentation by alveolar macrophages in patients with sarcoidosis."

Publications

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• Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.
• NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
• Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.
• RNase L Activates the NLRP3 Inflammasome during Viral Infections.
• ATG16L1 deficiency in macrophages drives clearance of uropathogenic E. coli in an IL-1β-dependent manner.
• Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
• Interruption of Macrophage-Derived IL-27(p28) Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3.
• NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease.
• Redundant and Cooperative Interactions between TLR5 and NLRC4 in Protective Lung Mucosal Immunity against Pseudomonas aeruginosa.
• Interleukin-22 Regulates the Complement System to Promote Resistance against Pathobionts after Pathogen-Induced Intestinal Damage.
• Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux.
• A genome-wide siRNA screen reveals NF-κB independent regulators of NOD2-induced IL-8 secretion.
• In vivo mapping of a protective linear neutralizing epitope at the N-terminus of alpha hemolysin from Staphylococcus aureus.
• Infection Mobilizes Hematopoietic Stem Cells through Cooperative NOD-like Receptor and Toll-like Receptor Signaling.
• Regulation of the Immune System by the Resident Intestinal Bacteria.
• Shigella Type III Secretion Protein MxiI Is Recognized by Naip2 to Induce Nlrc4 Inflammasome Activation Independently of Pkcδ.
• Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome.
• Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury.
• 3,4-Methylenedioxy-β-nitrostyrene inhibits NLRP3 activation by blocking assembly of the inflammasome.
• Staphylococcus δ-toxin induces allergic skin disease by activating mast cells.
• Control of pathogens and pathobionts by the gut microbiota.
• The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells.
• K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.
• Multiple effects of dendritic cell depletion on murine norovirus infection.
• Induction of bone loss by pathobiont-mediated nod1 signaling in the oral cavity.
• Role of the gut microbiota in immunity and inflammatory disease.
• The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages.
• Role of the gut microbiota in the development and function of lymphoid cells.
• A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-?B Signaling Pathways.
• MyD88: a critical adaptor protein in innate immunity signal transduction.
• TLR Agonists stimulate Nlrp3-dependent IL-1? production independently of the purinergic P2X7 receptor in dendritic cells and in vivo.
• Divergence of the systemic immune response following oral infection with distinct strains of Porphyromonas gingivalis.
• Influence of donor microbiota on the severity of experimental graft-versus-host-disease.
• Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation.
• Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells.
• IKKα negatively regulates ASC-dependent inflammasome activation.
• NOD-like receptors: role in innate immunity and inflammatory disease.
• Antigen presentation by alveolar macrophages in patients with sarcoidosis.

Doctors Specialties

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• Anatomic Pathology
• Pathology

Accepted Insurances

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Education

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• Washington University - Barnes-Jewish Hospital
• Universidad de Cadiz Faculty of Medicine

Hospital

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• University of Michigan Hospitals and Health Centers

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