Professor, Internal Medicine, Virginia Commonwealth University, Medical College of Virginia School of Medicine

Oncology

Dr. Geoffrey W. Krystal is an expert in the field of Oncology. He graduated from University of Miami Miller School of Medicine. University of Miami Miller School of Medicine has a rank of 45 in research and a 0 in primary care Doctor Geoffrey W. Krystal, MD is a published doctor. He published 101 publications, including: 'Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells.'

Publications

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• Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung Cancer.
• Early FDG/PET Scanning as a Pharmacodynamic Marker of Anti-EGFR Antibody Activity in ColoRectal Cancer.
• Teaching an old drug new tricks: Actinomycin D synergistically enhances sensitivity to the Bcl-2 antagonist ABT-737.
• Actinomycin D decreases Mcl-1 expression and acts synergistically with ABT-737 against small cell lung Cancer cell lines.
• Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung Cancer to the BH3 mimetic ABT-737.
• Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung Cancer.
• Imatinib inhibits c-Kit-induced hypoxia-inducible factor-1alpha activity and vascular endothelial growth factor expression in small cell lung Cancer cells.
• Receptor tyrosine kinase mutations: molecular indicators for therapeutic response or signposts marking important signaling pathways?
• The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung Cancer cell lines to the effects of chemotherapy.
• The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell Lung cance...
• Flavopiridol potently induces small cell lung Cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.
• Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung Cancer cells to chemotherapy.
• Role of small-molecule kit receptor tyrosine kinase inhibitors in the treatment of small-cell lung Cancer.
• Secretion of a unique peptide from interleukin-2-stimulated natural killer cells that induces endomitosis in immature human megakaryocytes.
• Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small cell lung Cancer.
• Comprehensive microRNA expression profiling of the hematopoietic hierarchy.
• The role of SHIP in cytokine-induced signaling.
• Interleukin-3 stimulates the tyrosine phosphorylation of the 140-kilodalton interleukin-3 receptor.
• Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs.
• Cardiac hypertrophy in the Dahl rat is associated with increased tyrosine phosphorylation of several cytosolic proteins, including a 120 kDa protein.
• The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
• Modulation of palmitate-induced cardiomyocyte cell death by interventions that alter intracellular calcium.
• Identification of the interleukin-3 receptor using an iodinatable, cleavable, photoreactive cross-linking agent.
• The mechanism of action of murine interleukin-3: current status.
• The rat prepro gastrin releasing peptide gene is transcribed from two initiation sites in the Brain.
• Ligand-induced phosphorylation of the murine interleukin 3 receptor signals its cleavage.
• SHIP, a new player in cytokine-induced signalling.
• Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.
• An enzyme-linked immunosorbent assay for erythropoietin using monoclonal antibodies, tetrameric immune complexes, and substrate amplification.
• A specific in vitro bioassay for measuring erythropoietin levels in human serum and plasma.
• Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin.
• Erythropoietin therapy of Myelodysplastic syndromes.
• Purification of human erythropoietin to homogeneity by a rapid five-step procedure.
• Use of a sensitive bioimmunoabsorbent assay to isolate and characterize monoclonal antibodies to biologically active human erythropoietin.
• Autocrine production of pre-B-cell stimulating activity by a variety of transformed murine pre-B-cell lines.
• Modulation by normal serum factors of Kirsten murine Sarcoma virus-induced transformation in adult rat cells infected in early passage.
• A second erythropoietin receptor subunit.
• Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation.
• Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells.
• Steel factor stimulates the serine/threonine phosphorylation of the interleukin-3 receptor.
• Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells.
• Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.
• Transforming growth factor beta 1 is an inducer of erythroid differentiation.
• Identification and characterization of an interleukin-3 receptor-associated 110-kDa serine/threonine kinase.
• Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene.
• Activation of multiple hemopoietic growth factor genes in Abelson virus-transformed myeloid cells.
• Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2.
• The role of SHIP in growth factor induced signalling.
• Phosphatidylinositol 3,4,5-trisphosphate regulates Ca(2+) entry via btk in platelets and megakaryocytes without increasing phospholipase C activity.
• The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its indu...
• The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation.
• Altered responsiveness to chemokines due to targeted disruption of SHIP.
• Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc.
• Induction of sensitivity to NK-mediated cytotoxicity by TNF-alpha treatment: possible role of ICAM-3 and CD44.
• Comparison of c-, N-, and L-myc transcriptional regulation.
• Partial characterization of a novel stromal cell-derived pre-B-cell growth factor active on normal and immortalized pre-B cells.
• Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.
• A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice.
• Regulation of phosphatidylinositol 3,4,5-trisphosphate 5'-phosphatase activity by insulin.
• Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in Ba/F3 cells via the IL-3 receptor alpha subunit.
• Identification of novel human tumor cell-specific CaMK-II variants.
• Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.
• Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB.
• A possible involvement of Stat5 in erythropoietin-induced hemoglobin synthesis.
• Effects of media conditions, insulin, and dexamethasone on insulin-receptor mRNA and promoter activity in HepG2 cells.
• Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation.
• Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein.
• Interleukin-3 down-regulates its own receptor.
• Phosphorylation of tyrosine 503 in the erythropoietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associa...
• The SH2-containing inositol-5'-phosphatase enhances LFA-1-mediated cell adhesion and defines two signaling pathways for LFA-1 activation.
• Effects of granulocyte-macrophage colony-stimulating factor and erythropoietin on leukemic erythroid colony formation in human early erythroblastic leukemias.
• Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.
• Engagement of Gab1 and Gab2 in erythropoietin signaling.
• Interleukin-3, GM-CSF, and TPA induce distinct phosphorylation events in an interleukin 3-dependent multipotential cell line.
• Activating c-kit gene mutations in human germ cell tumors.
• Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival.
• The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation.
• SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation.
• Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn.
• N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts.
• Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor.
• Erythropoietin-induced tyrosine phosphorylations in a high erythropoietin receptor-expressing lymphoid cell line.
• Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis.
• BCR-ABL accelerates C2-ceramide-induced apoptosis.
• Transcriptional activation and DNase I hypersensitive sites are associated with selective expression of the gastrin-releasing peptide gene.
• Small cell Carcinomas of the lung express the Bcl-2 protein.
• Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation.
• Thapsigargin-induced degranulation of mast cells is dependent on transient activation of phosphatidylinositol-3 kinase.
• Increased erythropoietin-receptor expression on CD34-positive bone marrow cells from patients with chronic myeloid leukemia.
• Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing BA/F3 cells.
• Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor.
• The hyperresponsiveness of cells expressing truncated erythropoietin receptors is contingent on insulin-like growth factor-1 in fetal calf serum.
• Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung Cancer.
• The expression of stem cell factor and its receptor, c-kit in human endometrium and placental Tissues during pregnancy.
• Selective Sp1 binding is critical for maximal activity of the human c-kit promoter.
• Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents.
• Coexpression of the c-kit and stem cell factor genes in Breast carcinomas.
• The selective tyrosine kinase inhibitor STI571 inhibits small cell lung Cancer growth.
• A novel assay for the measurement of Raf-1 kinase activity.
• G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase).

Schools

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• University Of Miami School Of Medicine

• Albert Einstein College Of Med Ofyeshiva University

• National Cancer Institute

Conditions Treated

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• Anal and Rectal Cancer
• Anemia
• Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
• Brain Cancer
• View All

Doctors Specialties

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• Medical Oncology
• Oncology

Accepted Insurances

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Education

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• National Institutes of Health Clinical Center
• Albert Einstein College of Medicine at Jacobi Medical Center
• University of Miami Miller School of Medicine

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