Professor, Internal Medicine, University of Michigan Medical School

Medical Genetics

Dr. Gilbert S. Omenn works in the field of Medical Genetics. He went to Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School is ranked 1/12 in Research/PrimaryCare. He received 3 awards: "Elected Member", "Investigator Alumnus" and "Whos Who in Medicine and Healthcare". Gilbert Omenn is a published doctor as well. He has 83 publications published. The latest was: Linking MedDRA()-Coded Clinical Phenotypes to Biological Mechanisms by the Ontology of Adverse Events: A Pilot Study on Tyrosine Kinase Inhibitors.

Publications

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• Use of ENCODE Resources to Characterize Novel Proteoforms and Missing Proteins in the Human Proteome.
• Revisiting the identification of canonical splice isoforms through integration of functional genomics and proteomics evidence.
• The emerging era of genomic data integration for analyzing splice isoform function.
• A new class of protein cancer biomarker candidates: Differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines.
• Regulation of the HERV-K (HML-2) transcriptome by the HIV-1 Tat protein.
• MetDisease - connecting metabolites to diseases via literature.
• Highlights of B/D-HPP and HPP Resource Pillar Workshops at Yokohama 12(th) Annual HUPO World Congress of Proteomics.
• Epithelial-mesenchymal Transition Associated Secretory Phenotype Predicts Survival in Lung Cancer Patients.
• Toward more transparent and reproducible omics studies through a common metadata checklist and data publications.
• On best practices: The Institute of Medicine scheme for developing, validating, and demonstrating clinical utility of omics-based diagnostic and predictive tests.
• Plasma Proteomics, The Human Proteome Project, and Cancer-Associated Alternative Splice Variant Proteins.
• Systematically Differentiating Functions for Alternatively Spliced Isoforms through Integrating RNA-seq Data.
• Distinct Splice Variants and Pathway Enrichment in the Cell-Line Models of Aggressive Human Breast Cancer Subtypes.
• The strategy, organization, and progress of the HUPO Human Proteome Project.
• The human eye proteome project.
• HIV Infection Reveals Wide-Spread Expansion of Novel Centromeric Human Endogenous Retroviruses.
• Innovations in proteomic profiling of cancers: Alternative splice variants as a new class of cancer biomarker candidates and bridging of proteomics with structural bio...
• A chromosome-centric human proteome project (C-HPP) to characterize the sets of proteins encoded in chromosome 17.
• Ontology-based combinatorial comparative analysis of adverse events associated with killed and live influenza vaccines.
• Healthcare information technology and economics.
• The human proteome - a scientific opportunity for transforming diagnostics, therapeutics, and healthcare.
• Evolutionary molecular medicine.
• Metab2MeSH: Annotating Compounds with Medical Subject Headings (MeSH).
• Metscape 2 Bioinformatics Tool for the Analysis and Visualization of Metabolomics and Gene Expression Data.
• Recommendations for Mass Spectrometry Data Quality Metrics for Open Access Data (Corollary to the Amsterdam Principles).
• Recommendations for mass apectrometry data quality metrics for open access data (corollary to the Amsterdam principles).
• Functional Implications of Structural Predictions for Alternative Splice Proteins Expressed in Her2/neu-Induced Breast Cancers.
• Identifying Inhibitors of Epithelial-Mesenchymal Transition by Connectivity Map-Based Systems Approach.
• The human proteome project: current state and future direction.
• A high-confidence human plasma proteome reference set with estimated concentrations in PeptideAtlas.
• Characterization of KRAS Rearrangements in Metastatic Prostate Cancer.
• Identification of alternatively spliced transcripts using a proteomic informatics approach.
• Data management and data integration in the HUPO plasma proteome project.
• Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen IA-2 heightens the risk of type 1 diabetes.
• Proteomic characterization of novel alternative splice variant proteins in human epidermal growth factor receptor 2/neu-induced breast cancers.
• Overview of the symposium on public health significance of genomics and eco-genetics.
• Quantitative proteomic profiling of prostate cancer reveals a role for miR-128 in prostate cancer.
• Evolution in health and medicine Sackler colloquium: Evolution and public health.
• Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine.
• "Topological significance" analysis of gene expression and proteomic profiles from prostate cancer cells reveals key mechanisms of androgen response.
• An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer.
• Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses.
• Mucin glycosylation is altered by pro-inflammatory signaling in pancreatic-cancer cells.
• Systematic comparison of the human saliva and plasma proteomes.
• Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer.
• Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases.
• Temporal quantitative proteomics by iTRAQ 2D-LC-MS/MS and corresponding mRNA expression analysis identify post-transcriptional modulation of actin-cytoskeleton regulat...
• Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor.
• The relative merits of population-based and targeted prevention strategies.
• Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
• Immunology and genetics of type 1 diabetes.
• Development and validation of sandwich ELISA microarrays with minimal assay interference.
• Coupled global and targeted proteomics of human embryonic stem cells during induced differentiation.
• Humoral response profiling reveals pathways to prostate cancer progression.
• Human Proteinpedia enables sharing of human protein data.
• Meeting report: hazard assessment for nanoparticles--report from an interdisciplinary workshop.
• A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury.
• Standards for plasma and serum proteomics in early cancer detection: a needs assessment report from the national institute of standards and technology--National Cancer...
• Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotype.
• A scientific supercourse.
• Biorepositories: let's not lose what we have so carefully gathered!
• Challenges in deriving high-confidence protein identifications from data gathered by a HUPO plasma proteome collaborative study.
• Medicine needs evolution.
• Seizing the opportunities.
• Commentary on scientific peer review to inform regulatory decision making: roles and perspectives of scientists.
• Evidence for excess colorectal cancer incidence among asbestos-exposed men in the Beta-Carotene and Retinol Efficacy Trial.
• Intact-protein-based high-resolution three-dimensional quantitative analysis system for proteome profiling of biological fluids.
• Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation.
• Predictors of lung cancer among asbestos-exposed men in the {beta}-carotene and retinol efficacy trial.
• Physical activity in relation to all-site and lung cancer incidence and mortality in current and former smokers.
• The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and re...
• Human lung cancer chemoprevention strategies: Parker B. Francis lecture.
• Development of natural protein microarrays for diagnosing cancer based on an antibody response to tumor antigens.
• The association between lung and prostate cancer risk, and serum micronutrients: results and lessons learned from beta-carotene and retinol efficacy trial.
• Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta-carotene and retinol efficacy trial (CARET).
• The crucial role of the public health sciences in the postgenomic era.
• Genetic advances will influence the practice of medicine: examples from cancer research and care of cancer patients.
• Streamlining IRB review in multisite trials through single-study IRB Cooperative Agreements: experience of the Beta-Carotene and Retinol Efficacy Trial (CARET).
• Presidential commission on biomedical ethics launched.
• Novel Bioinformatics Method for Identification of Genome-Wide Non-Canonical Spliced Regions Using RNA-Seq Data.
• Current perspective on the global and United States cancer burden attributable to lifestyle and environmental risk factors.
• Linking MedDRA(®)-Coded Clinical Phenotypes to Biological Mechanisms by the Ontology of Adverse Events: A Pilot Study on Tyrosine Kinase Inhibitors.

Schools

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• Harvard Medical School

• Massachusetts General Hospital

• University of Washington

Doctors Specialties

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• Clinical Genetics
• Internal Medicine
• Medical Genetics

Accepted Insurances

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Awards

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• Elected Member
• Investigator Alumnus
• Whos Who in Medicine and Healthcare

Education

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• Massachusetts General Hospital
• Harvard Medical School

Hospital

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• University of Michigan Hospitals and Health Centers

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