Professor, Internal Medicine, Mayo Med Sch
Gastroenterology
Gregory Gores works in the field of Gastroenterology. He attended University of North Dakota School of Medicine and Health Sciences. He received 27 awards: "Research Career Achievement Award - Department of Internal Medicine", "Distinguished Mayo Investigator Award", "Fellow (AGAF)", "Fellow", "Award For Outstanding Mentorship - Department of Internal Medicine", "Best Doctors in America", "Outstanding Investigator Award, Department of Internal Medicine", "Reuben R. Eisenberg Professorship", "Merit Award", "Elected Member", "Fellow (FACP)", "J. Arnold Bargen Award in Gastroenterology, for Outstanding Performance as a Subspecialty Trainee in Gastroenterology - Division of Gastroenterology and Hepatology, Department of Internal Medicine", "Mayo Foundation Scholar Laboratories for Cell Biology - Department of Cell Biology and Anatomy", "Eugenie M. Boltz Teaching and Research Scholarship Award in Gastroenterology for Outstanding Performance as a Subspecialty Trainee in Gastroenterology - Division of Gastroenterology and Hepatology, Department of Internal Medicine", "Postdoctoral Research Fellowship of American Liver Foundation- Gastroenterology Research Unit", "Outstanding Young Men of America", "Graduate Travel Award, for Excellence in Internal Medicine - Department of Internal Medicine", "Upjohn Achievement Award, for Academic Achievement in Medical School", "Alpha Omega Alpha Honor Society", "Dr. Saiki Award, for Excellence in Pathology", "Phi Beta Kappa Honor Society", "Psi Chi, The International Honor Society in Psychology", "Grand Marshall of Graduation Ceremonies, for Academic Achievement", "Maxwell Upjohn Scholarship", "Outstanding Freshman Award for Academic Achievement", "Balfour Honor Key" and "Fellow (FACG)". Gregory Gores is a published doctor. He published 100 publications, including: 'Differential Requirement for de novo Lipogenesis in Cholangiocarcinoma and Hepatocellular Carcinoma of Mice and Humans.'
Publications
- Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles.
- Inheriting a Jewel: A Thrilling Challenge.
- Differential Requirement for de novo Lipogenesis in Cholangiocarcinoma and Hepatocellular Carcinoma of Mice and Humans.
- Primary Sclerosing Cholangitis as a Premalignant Biliary Tract Disease: Surveillance and Management.
- Regenerative Medicine Build-Out.
- Fibroblast growth factor receptor 2 fusions as a target for treating cholangiocarcinoma.
- The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatoHepatitis.
- Triple modality testing by endoscopic retrograde cholangiopancreatography for the diagnosis of cholangiocarcinoma.
- Biliary multifocal chromosomal polysomy and cholangiocarcinoma in primary sclerosing cholangitis.
- Awareness of tract seeding with endoscopic ultrasound tissue acquisition in perihilar cholangiocarcinoma.
- Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic SteatoHepatitis.
- Decreasing mitochondrial fission prevents cholestatic liver injury.
- Trail Receptor Deletion in Mice Suppresses the Inflammation of Nutrient Excess.
- A New Clinically Based Staging System for Perihilar Cholangiocarcinoma.
- Cholangiocarcinoma: molecular pathways and therapeutic opportunities.
- Metformin does not improve survival in patients with hepatocellular carcinoma.
- Liver transplantation for intrahepatic cholangiocarcinoma--Authors' reply.
- Decade in review-hepatocellular carcinoma: HCC-subtypes, stratification and sorafenib.
- Ballooned hepatocytes, undead cells, sonic hedgehog and vitamin E: Therapeutic implications for NASH.
- Alcoholic Hepatitis: current challenges and future directions.
- Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma.
- Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma.
- Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma.
- Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas.
- Degradation of cIAPs contributes to hepatocyte lipoapoptosis.
- Desmoplastic Stroma and Cholangiocarcinoma: Clinical Implications and Therapeutic Targeting.
- Pathogenesis, Diagnosis, and Management of Cholangiocarcinoma.
- Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatoHepatitis.
- Complete lysosomal disruption: A route to necrosis, not to the inflammasome.
- Primary sclerosing cholangitis with equivocal cytology: Fluorescence in situ hybridization and serum CA 19-9 predict risk of malignancy.
- Pathogenesis of Primary Sclerosing Cholangitis and Advances in Diagnosis and Management.
- Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions.
- Risk factors for intrahepatic cholangiocarcinoma: association between metformin use and reduced Cancer risk.
- Excellent quality of life after liver transplantation in patients with perihilar cholangiocarcinoma who have undergone neoadjuvant chemoradiation.
- Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma.
- Notch driven carcinogenesis: The merging of hepatocellular Cancer and cholangiocarcinoma into a common molecular liver Cancer subtype.
- Classification, diagnosis, and management of cholangiocarcinoma.
- A hedgehog survival pathway in 'undead' lipotoxic hepatocytes.
- Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein-induced Lysosomal Translocation of Proapoptotic Effectors Is Mediated by Phosphofurin Acidic Cl...
- Biliary Tract Cancers in Olmsted County, Minnesota, 1976-2008.
- Efficacy of Neoadjuvant Chemoradiation, Followed by Liver Transplantation, for Perihilar Cholangiocarcinoma at 12 US Centers.
- Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma.
- Pretransplant psychiatric and substance use comorbidity in patients with cholangiocarcinoma who received a liver transplant.
- Targeting Tumor Stroma: Exploiting Apoptotic Priming.
- Targeting PDGFR-β in Cholangiocarcinoma.
- Myofibroblast-derived PDGF-BB promotes hedgehog survival signaling in cholangiocarcinoma cells.
- Mechanisms of Lysophosphatidylcholine-Induced Hepatocyte Lipoapoptosis.
- Death receptor 5 signaling promotes hepatocyte lipoapoptosis.
- Trains, Tracks, and Promotion in an Academic Medical Center.
- High cell surface death receptor expression determines type I versus type II signaling.
- Primary Sclerosing Cholangitis Patients With Serial Polysomy Fluorescence In Situ Hybridization Results Are at Increased Risk of Cholangiocarcinoma.
- Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition.
- Clinical diagnosis and staging of cholangiocarcinoma.
- Hepatic stellate cells: Partners in crime for liver metastases?
- MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint.
- Cancer surveillance in patients with primary sclerosing cholangitis.
- A role for miR-296 in the regulation of lipoapoptosis by targeting PUMA.
- Mechanisms of Lipotoxicity in NAFLD and Clinical Implications.
- Who pulls the trigger: JNK activation in liver lipotoxicity?
- A stunning year for advances in Biliary tract disease.
- Epithelial cell specificity and apotope recognition by serum autoantibodies in primary Biliary cirrhosis.
- A Klothoβ Variant Mediates Protein Stability and Associates With Colon Transit in Irritable Bowel Syndrome With Diarrhea.
- Sorafenib for HCC: a pragmatic perspective.
- Hedgehog Inhibition Promotes a Switch from Type II to Type I Cell Death Receptor Signaling in Cancer Cells.
- Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.
- Open access journals: why are we not there yet? (!).
- Positron emission tomography scan for a hepatic mass.
- Comparison of KRAS mutation analysis and FISH for detecting pancreatoBiliary tract cancer in cytology specimens collected during endoscopic retrograde cholangiopancrea...
- Apoptosis as a mechanism for liver Disease progression.
- Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary Biliary cirrhosis.
- A smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cells.
- American Association for the Study of Liver Diseases endpoints conference: design and endpoints for clinical trials in primary Biliary cirrhosis.
- Hepatocyte death: a clear and present danger.
- CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis.
- Academic gastroenterology and hepatology: training tracts and competencies.
- A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells.
- Mechanisms and clinical implications of hepatocyte lipoapoptosis.
- Deleted in breast Cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice.
- Long-term probability of and mortality from de novo malignancy after liver transplantation.
- Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.
- Report of the multisociety task force on GI training.
- Mcl-1 degradation during hepatocyte lipoapoptosis.
- The liver's dance with death: two Bcl-2 guardian proteins from the abyss.
- JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis.
- Overexpression of mcl-1 attenuates liver injury and fibrosis in the bile duct-ligated mouse.
- Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.
- Caspase inhibitors for the treatment of Hepatitis C.
- Hepatology: a home for hepatocellular Cancer publications.
- Death receptor 5 internalization is required for lysosomal permeabilization by TRAIL in malignant liver cell lines.
- Life and death by death receptors.
- A multivariable model using advanced cytologic methods for the evaluation of indeterminate pancreatoBiliary strictures.
- MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.
- A conceptual proposal for staging ductal cholangiocarcinoma.
- Transplantation for cholangiocarcinoma: when and for whom?
- Apotopes and the Biliary specificity of primary Biliary cirrhosis.
- Proteasome inhibition causes apoptosis of normal human plasma cells preventing alloantibody production.
- MicroRNAs: key modulators of posttranscriptional gene expression.
- Adequacy of endoscopic ultrasound core needle biopsy specimen of nonmalignant hepatic parenchymal Disease.
- Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes.
Schools
University Of North Dakota School Of Medicine
Mayo Grad School Med
Mayo Clinic Rochester
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
- Liver Biopsy
Conditions Treated
- Abdominal Pain
- Anemia
- Benign Neoplasm of the Digestive System
- Biliary Atresia
- View All
Doctors Specialties
Accepted Insurances
Awards
- Research Career Achievement Award - Department of Internal Medicine
- Distinguished Mayo Investigator Award
- Fellow (AGAF)
- Fellow
- Award For Outstanding Mentorship - Department of Internal Medicine
- Best Doctors in America
- Outstanding Investigator Award, Department of Internal Medicine
- Reuben R. Eisenberg Professorship
- Merit Award
- Elected Member
- Fellow (FACP)
- J. Arnold Bargen Award in Gastroenterology, for Outstanding Performance as a Subspecialty Trainee in Gastroenterology - Division of Gastroenterology and Hepatology, Department of Internal Medicine
- Mayo Foundation Scholar Laboratories for Cell Biology - Department of Cell Biology and Anatomy
- Eugenie M. Boltz Teaching and Research Scholarship Award in Gastroenterology for Outstanding Performance as a Subspecialty Trainee in Gastroenterology - Division of Gastroenterology and Hepatology, Department of Internal Medicine
- Postdoctoral Research Fellowship of American Liver Foundation- Gastroenterology Research Unit
- Outstanding Young Men of America
- Graduate Travel Award, for Excellence in Internal Medicine - Department of Internal Medicine
- Upjohn Achievement Award, for Academic Achievement in Medical School
- Alpha Omega Alpha Honor Society
- Dr. Saiki Award, for Excellence in Pathology
- Phi Beta Kappa Honor Society
- Psi Chi, The International Honor Society in Psychology
- Grand Marshall of Graduation Ceremonies, for Academic Achievement
- Maxwell Upjohn Scholarship
- Outstanding Freshman Award for Academic Achievement
- Balfour Honor Key
- Fellow (FACG)
Education
-
Mayo School of Graduate Medical Education
-
University of North Dakota School of Medicine and Health Sciences
Hospital
-
Mayo Clinic - Rochester, Minnesota
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