Mallinckrodt Distinguished Professor of Pathology, Beth Israel Deaconess Medical Center
Pathology
Dr. Harold F. Dvorak, MD
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Harold Dvorak works in the field of Pathology. He went to medical school at Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1 in research and 12 in primary care medicine Dr. Harold F. Dvorak is a published doctor and has 35 publications published. The lastest was: 'TM4SF1: a new vascular therapeutic target in cancer.'
Publications
- TM4SF1: a new vascular therapeutic target in cancer.
- The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1.
- Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target.
- Tumor surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy.
- Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions.
- TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration.
- Proteolytic Cleavage of Versican and Involvement of ADAMTS-1 in VEGF-A/VPF-Induced Pathological Angiogenesis.
- Tumor microenvironment and progression.
- Vascular permeability to plasma, plasma proteins, and cells: an update.
- Heterogeneity of the tumor vasculature.
- Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level.
- Vascular permeability and pathological angiogenesis in caveolin-1-null mice.
- Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase.
- VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation.
- The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis.
- Chapter 3. The adenoviral vector angiogenesis/lymphangiogenesis assay.
- Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
- Transcellular diapedesis is initiated by invasive podosomes.
- VEGF-A and the induction of pathological angiogenesis.
- Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway.
- Permeability properties of tumor surrogate blood vessels induced by VEGF-A.
- Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
- Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity.
- Discovery of vascular permeability factor (VPF).
- Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.
- Ultrastructural localization of platelet endothelial cell adhesion molecule (PECAM-1, CD31) in vascular endothelium.
- VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis.
- Rous-Whipple Award Lecture. How tumors make bad blood vessels and stroma.
- Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis.
- Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins.
- Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.
- Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.
- Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated mic...
- Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stage...
Schools
Harvard Medical School
Massachusetts General Hospital
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Education
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Massachusetts General Hospital -
Harvard Medical School
Hospital
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Beth Israel Deaconess Medical Center
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