Professor of Medicine, Brigham and Women's Hospital

Hematology

Dr. Howard F. Bunn, MD

Howard F. Bunn works in the field of Hematology. He went to Perelman School of Medicine at the University of Pennsylvania. Howard F. Bunn, MD has written publications. He has 44 publications published with PubMed. The lastest publication is: 'Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.'

Publications

Erythropoietin.
Practicing Biochemistry without a License.
The triumph of good over evil: protection by the sickle gene against malaria.
Pulmonary hypertension and nitric oxide depletion in sickle cell disease.
The flavoheme reductase Ncb5or protects cells against endoplasmic reticulum stress-induced lipotoxicity.
End run around epo.
Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes.
Hematopoietic cell transplantation for hemoglobinopathies.
New agents that stimulate erythropoiesis.
Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus.
Hypoxia-induced synthesis of hemoglobin in the crustacean Daphnia magna is hypoxia-inducible factor-dependent.
Regulation of Drosophila hypoxia-inducible factor (HIF) activity in SL2 cells: identification of a hypoxia-induced variant isoform of the HIFalpha homolog gene similar.
Absence of a reductase, NCB5OR, causes insulin-deficient diabetes.
NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum.
Hypoxia-inducible factor and its biomedical relevance.
Sugar in erythropoietin: clinical and forensic implications.
Drug-induced autoimmune red-cell aplasia.
Signal transduction. How do cells sense oxygen?
Cadmium and platinum suppression of erythropoietin production in cell culture: clinical implications.
Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells.
Regulation of the erythropoietin gene.
Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling.
Induction of fetal hemoglobin in sickle cell disease.
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.
Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB bindin...
Homodimerization restores biological activity to an inactive erythropoietin mutant.
Pathogenesis and treatment of sickle cell disease.
Erythropoietin gene regulation depends on heme-dependent oxygen sensing and assembly of interacting transcription factors.
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit.
An essential role for p300/CBP in the cellular response to hypoxia.
Pitfalls of genetic testing.
Oxygen sensing and molecular adaptation to hypoxia.
Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein.
Educating the biomedical scientist.
Use of a marked erythropoietin gene for investigation of its cis-acting elements.
The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is an...
Regulation of erythropoietin gene expression.
UROS and ALAS-2: erstwhile partners in crime.
Pulmonary thrombectomy in a patient with hemoglobin Nottingham.
Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells.
Detecting and responding to hypoxia.
Promoter characterization and transcriptional regulation of Ncb5or, a novel reductase necessary for pancreatic beta-cell maintenance.
The reductase NCB5OR is responsive to the redox status in beta-cells and is not involved in the ER stress response.

Schools

Perelman School of Medicine University of Pennsylvania
New York Hospital
Thorndike Meml Lab Boston C

Doctors Specialties

Hematology

Accepted Insurances

Education

Boston University Medical Center
New York Presbyterian Hospital - Cornell Campus
Perelman School of Medicine at the University of Pennsylvania

Hospital

Brigham and Women's Hospital

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Professor of Medicine, Brigham and Women&#39;s Hospital