Assistant Professor, Pathology and Immunology, Washington University School of Medicine

Pathology

Jacqueline Payton is an expert in the field of Pathology. She went to University of Illinois College of Medicine. Jacqueline Payton is a published physician. She has 36 publications published. The most current publication "Mapping of Variable DNA Methylation across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome."

Publications

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• Maternal T-Cell Engraftment Interferes With Human Leukocyte Antigen Typing in Severe Combined Immunodeficiency.
• RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.
• Mapping of Variable DNA Methylation across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome.
• Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma.
• HCoDES Reveals Chromosomal DNA End Structures with Single-Nucleotide Resolution.
• Validation of a Next-Generation Sequencing Assay for Clinical Molecular Oncology.
• Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data.
• Quantitative Label-Free Proteomics for Discovery of Biomarkers in Cerebrospinal Fluid: Assessment of Technical and Inter-Individual Variation.
• The changing spectrum of DNA-based specimen provenance testing in surgical pathology.
• Genome-wide polymorphism analysis demonstrates a monoclonal origin of pilocytic astrocytoma.
• Protein-protein interactions of alpha-synuclein in brain homogenates and transfected cells.
• Epitope mapping and specificity of the anti-alpha-synuclein monoclonal antibody Syn-1 in mouse brain and cultured cell lines.
• POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.
• DNMT3A mutations in acute myeloid leukemia.
• A protease-resistant PML-RAR{alpha} has increased leukemogenic potential in a murine model of acute promyelocytic leukemia.
• Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.
• Identification of transcriptional regulatory networks specific to pilocytic astrocytoma.
• Use of whole-genome sequencing to diagnose a cryptic fusion oncogene.
• Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML.
• Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.
• Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor.
• Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.
• Latent herpesvirus infection arms NK cells.
• Interleukin 12 stimulates IFN-gamma-mediated inhibition of tumor-induced regulatory T-cell proliferation and enhances tumor clearance.
• Recurring mutations found by sequencing an acute myeloid leukemia genome.
• Acquired copy number alterations in adult acute myeloid leukemia genomes.
• High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.
• Dicer and outcomes in patients with acute myeloid leukemia (AML).
• DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.
• Single-agent lenalidomide induces complete remission of acute myeloid leukemia in patients with isolated trisomy 13.
• Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia.
• Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
• Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.
• Commonly dysregulated genes in murine APL cells.
• Structural determinants of PLD2 inhibition by alpha-synuclein.

Schools

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• University of Illinois At Chicago College of Medicine

Doctors Specialties

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• Clinical Pathology
• Pathology

Accepted Insurances

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Education

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• Washington University
• University of Illinois College of Medicine

Hospital

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• Barnes-Jewish Hospital

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