Professor, Neurology, University of Texas Medical School, Houston
Neurology
Dr. James A. Ferrendelli, MD
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James Ferrendelli is an expert in the field of Neurology. He studied medicine at University of Kentucky College of Medicine. University of Kentucky College of Medicine is ranked 63 in research and 72 in primary care medicine He has 5 awards "America's Top Doctors", "Top Doctors:SE Texas", "Meaningful Use Stage 1 Certification", "Super Doctor" and "Whos Who in Medicine and Healthcare". Doctor James A. Ferrendelli, MD is also published. He has 101 publications published. The lastest publication: "Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.' He is registered with Medicare and accepts Medicare payments.
Publications
- What you see is not what you get: believing patient-reported seizure counts.
- Enantioselectivity of alpha-benzyl-alpha-methyl-gamma-butyrolactone-mediated modulation of anticonvulsant activity and GABA(A) receptor function.
- The KEEPER trial: levetiracetam adjunctive treatment of partial-onset seizures in an open-label community-based study.
- Regional levels of glucose, amino acids, high energy phosphates, and cyclic nucleotides in the central nervous system during hypoglycemic stupor and behavioral recovery.
- Concerns with antiepileptic drug initiation: safety, tolerability, and efficacy.
- Pharmacology of antiepileptic drug polypharmacy.
- Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.
- Use of rational polypharmacy to treat Epilepsy.
- Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site.
- Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones.
- Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams).
- Rational polypharmacy.
- Physiological comparison of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors.
- 3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents.
- Alkyl-substituted gamma-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex.
- Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubsti...
- Developmental alteration in GABAA receptor structure and physiological properties in cultured cerebellar granule neurons.
- Relating pharmacology to clinical practice: the pharmacologic basis of rational polypharmacy.
- Dual modulation of the gamma-aminobutyric acid type A receptor/ionophore by alkyl-substituted gamma-butyrolactones.
- Regional cortical metabolism in focal ischemia.
- Kainic acid-induced limbic seizures: electrophysiologic studies.
- Structure-activity relationships of alkyl-substituted gamma-butyrolactones and succinimides.
- Anticonvulsant properties of alpha, gamma, and alpha, gamma-substituted gamma-butyrolactones.
- Comparison of epileptogenic properties of unsubstituted and beta-alkyl-substituted gamma-butyrolactones.
- Isoniazid and other drugs.
- Comparative actions of phenytoin and other anticonvulsant drugs on potassium- and veratridine-stimulated calcium uptake in synaptosomes.
- Regionally selective metabolic effects of hypoglycemia in Brain.
- Succinimides.
- Phenobarbital and phenytoin in neonatal seizures.
- Neurophysiologic effects of folate compounds in hippocampus, in vitro.
- Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs.
- Effect of anticonvulsant drugs on kainic acid-induced epileptiform activity.
- Adenylate cyclases in the vertebrate retina: distribution and characteristics in rabbit and ground squirrel.
- Adenylate cyclases in vertebrate retina: enzymatic characteristics in normal and dystrophic mouse retina.
- Primidone, phenobarbital, and PEMA: II. Seizure protection, neuroToxicity, and therapeutic index of varying combinations in mice.
- Primidone, phenobarbital, and PEMA: I. Seizure protection, neuroToxicity, and therapeutic index of individual compounds in mice.
- Effects of alkyl-substituted gamma-butyrolactones and succinimides on the evoked and spontaneous activity of hippocampal slices in vitro.
- Measurement of prostaglandin biosynthetic capacity in Discrete areas of the rabbit hippocampal formation.
- Interruption of the mammillothalamic tract prevents seizures in guinea pigs.
- Alkyl-substituted gamma-butyrolactones as potential tools in the study and treatment of Epilepsy.
- Localization of an endogenous substrate for cyclic AMP-stimulated protein phosphorylation in retina.
- Roles of cyclic nucleotides in pathophysiologic mechanisms of seizures.
- Computer-assisted modeling of the picrotoxinin and gamma-butyrolactone receptor site.
- Relationship between seizures and cyclic nucleotides in the central nervous system.
- Cyclic nucleotide levels in light- and dark-adapted ground squirrel whole eyes.
- Relationships between norepinephrine and cyclic nucleotides in Brain and seizure activity.
- Microdissection of retina and measurement of cyclic nucleotides.
- Relationships between seizure activity and cyclic nucleotide levels in Brain.
- Epilepsy and cyclic nucleotides.
- Phenytoin: cyclic nucleotide regulation in the Brain.
- Mechanisms of cyclic AMP regulation in Cerebral anoxia and their relationship to glycogenolysis.
- Potentiation of the antiepileptic activity of phenobarbital by nicotinamide.
- Interactions between primidone, carbamazepine, and nicotinamide.
- Regulatory effects of neurotransmitters on electroshock and pentylenetetrazol seizures.
- Cyclic GMP systems in the retina.
- Characterization and localization of adenylate and guanylate cyclases.
- The distribution of the components of the cyclic GMP cycle in retina.
- Serum creatine phosphokinase in muscle Disease. An evaluation of two methods of determination and comparison with serum aldolase.
- The effect of audiogenic seizures on regional CNS energy reserves, glycolysis and citric acid cycle flux.
- The effect of electroshock on regional CNS energy reserves in mice.
- Regional changes in CNS levels of the S-100 and 14-3-2 proteins during development and aging of the mouse.
- Quick freezing of the murine CNS: comparison of regional cooling rates and metabolite levels when using liquid nitrogen of Freon-12.
- Inhibition of Brain adenylate cyclase by ethacrynic acid and dithiobisnitrobenzoic acid.
- Inhibition of Ca ++ transport into rat Brain synaptosomes by diphenylhydantoin (DPH).
- Brain metabolism during hypoglycemia. Effect of insulin on regional central nervous system glucose and energy reserves in mice.
- Cerebral utilization of nonglucose substrates and their effect in hypoglycemia.
- Mechanism of action of nerve growth factor and cyclic AMP on neurite outgrowth in embryonic chick sensory ganglia: demonstration of independent pathways of stimulation.
- Elevation of cyclic GMP levels in central nervous system by excitatory and inhibitory amino acids.
- Adenosine cyclic 3'':5''-monophosphate-mediated transport of neutral and dibasic amino acids in jejunal mucosa.
- Regulation of levels of guanosine cyclic 3'',5''-monophosphate in the central nervous system: effects of depolarizing agents.
- Effects of amphetamine, chlorpromazine and reserpine on cyclic GMP and cyclic AMP levels in mouse cerebellum.
- Radioimmunoassay for cyclic nucleotides. 3. Effect of ischemia, changes during development and regional distribution of adenosine 3'',5''-monophosphate and guanosine 3...
- The effect of oxotremorine and atropine on cGMP and cAMP levels in mouse Cerebral cortex and cerebellum.
- Regional energy metabolism and lipofuscin accumulation in mouse Brain during aging.
- Anterior thalamus and substantia nigra: two distinct structures mediating experimental generalized seizures.
- Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
- Roles of biogenic amines and cyclic nucleotides in seizure mechanisms.
- Phenytoin and carbamazepine, alone and in combination: anticonvulsant and neuroToxic effects.
- Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake.
- Anterior thalamic mediation of generalized pentylenetetrazol seizures.
- Functional anatomy of pentylenetetrazol and electroshock seizures in the rat Brainstem.
- A rat EEG model for evaluating contrast media neuroToxicity.
- Interruption of the connections of the mammillary bodies protects against generalized pentylenetetrazol seizures in guinea pigs.
- Lennox-Gastaut Syndrome and positron emission tomography.
- Selective metabolic activation of the mammillary bodies and their connections during ethosuximide-induced suppression of pentylenetetrazol seizures.
- Convulsant and anti-convulsant gammabutyrolactones bind at the picrotoxinin/T-butylbicyclophosphorothionate (TBPS) receptor.
- Identification of a median thalamic system regulating seizures and arousal.
- Comparison of the anticonvulsant activities of ethosuximide, valproate, and a new anticonvulsant, thiobutyrolactone.
- Pharmacology of antiepileptic drugs.
- Adenosine-mediated regulation of cyclic AMP levels in isolated incubated retinas.
- Indoleamine-sensitive adenylate cyclase in rabbit retina: characterization and distribution.
- Physiological regulation of the picrotoxin receptor by gamma-butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons.
- The central medial nucleus: thalamic site of seizure regulation.
- Use of nonradioactive 2-deoxyglucose to study compartmentation of Brain glucose metabolism and rapid regional changes in rate.
- Electroencephalographic effects of intracisternally injected nonionic x-ray contrast media in rats.
- Characterization of GABAergic seizure regulation in the midline thalamus.
- Binding interactions of convulsant and anticonvulsant gamma-butyrolactones and gamma-thiobutyrolactones with the picrotoxin receptor.
- Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons.
- Convulsant and anticonvulsant cyclopentanones and cyclohexanones.
- Eyelid twitching seizures and generalized tonic-clonic Convulsions: a syndrome of idiopathic generalized epilepsy.
Schools
University Of Colorado School Of Medicine
University Ky Med Center
Cleveland Metropolitan General Hospital
Wash University Med School
Procedures Preformed
- EEG (Electroencephalogram)
Conditions Treated
- Alzheimer's Disease
- Ataxia
- Brain Aneurysm
- Brain Injury
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Doctors Specialties
- Neurology
Accepted Insurances
Awards
- America's Top Doctors
- Top Doctors:SE Texas
- Meaningful Use Stage 1 Certification
- Super Doctor
- Whos Who in Medicine and Healthcare
Education
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Case Western Reserve University - MetroHealth -
University of Kentucky College of Medicine -
University of Colorado Denver School of Medicine
Drug Facts
| NPI NUMBER | 1700812104 | |
| NPPES Provider LastName | FERRENDELLI | |
| NPPES Provider FirstName | JAMES | |
| NPPES Provider ZIPCode | 770303000 | |
| NPPES Provider State | TX | |
| Specialty Description | Neurology | |
| Total Claim Count | 942.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1700812104 |
| Last Name Of The Provider | FERRENDELLI |
| First Name Of The Provider | JAMES |
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