Physician
Nephrology
Dr. James A. Shayman, MD
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James Shayman is an expert in the field of Nephrology. He studied medicine at Washington University School of Medicine in St. Louis. He received awards:"Elected Member" and "Fellow (ASNF)". James Shayman is a published doctor as well. He has 99 publications published. The latest was: Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation.
Publications
- Challenges and opportunities in the development of therapeutics for Chronic kidney disease.
- Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry Disease.
- A hemolytic anti-LKE associated with a rare LKE-negative, "weak P" red blood cell phenotype: alloanti-LKE and alloanti-P recognize galactosylgloboside and monosialogal...
- Thematic review series: Recent advances in the treatment of lysosomal storage Diseases.
- The Development and use of Small Molecule Inhibitors of Glycosphingolipid Metabolism for Lysosomal Storage Diseases.
- Endothelial Nitric Oxide Synthase Uncoupling and Microvascular Dysfunction in the Mesentery of Mice Deficient in α-Galactosidase A.
- In memoriam: Norman S. Radin (1920-2013).
- Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.
- Drug induced phospholipidosis: an acquired lysosomal storage disorder.
- A fluorogenic phospholipid for the detection of lysosomal phospholipase A2 activity.
- Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain.
- Lowering Glycosphingolipid Levels in CD4+ T Cells Attenuates T Cell Receptor Signaling, Cytokine Production, and Differentiation to the Th17 Lineage.
- The measurement of lysosomal phospholipase A2 activity in plasma.
- Inhibition of glucosylceramide accumulation results in effective blockade of polycystic Kidney disease in mouse models.
- The riddle of the sphinx redux.
- Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase.
- Ceramide-1-phosphate in phagocytosis and calcium homeostasis.
- Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry Disease.
- The role of negatively charged lipids in lysosomal phospholipase A2 function.
- Decreased nitric oxide bioavailability in a mouse model of Fabry Disease.
- Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.
- Ganglioside-linked terminal sialic acid moieties on murine macrophages function as attachment receptors for murine noroviruses.
- Differential involvement of COX1 and COX2 in the vasculopathy associated with the alpha-galactosidase A-knockout mouse.
- The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages.
- Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry Disease endothelial cells.
- Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice.
- Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells.
- Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells.
- The acylation of lipophilic alcohols by lysosomal phospholipase A2.
- Caveolin-associated accumulation of globotriaosylceramide in the vascular endothelium of alpha-galactosidase A null mice.
- A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy of Gaucher Disease.
- Alpha-galactosidase A in vascular Disease.
- Positional specificity of lysosomal phospholipase A2.
- Lysosomal phospholipase A2 and phospholipidosis.
- Alpha-galactosidase A deficiency leads to increased tissue fibrin deposition and thrombosis in mice homozygous for the factor V Leiden mutation.
- Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells.
- Thinking about rare Kidney diseases.
- Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues.
- An in vitro model of Fabry Disease.
- Ceramide 1-phosphate, a mediator of phagocytosis.
- Phagocytic signaling molecules in lipid rafts of COS-1 cells transfected with FcgammaRIIA.
- Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency.
- Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages.
- Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells.
- Ceramide inhibition of phospholipase D and its relationship to RhoA and ARF1 translocation in GTP gamma S-stimulated polymorphonuclear leukocytes.
- A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide tra...
- Src kinase mediates the regulation of phospholipase C-gamma activity by glycosphingolipids.
- Fabry Disease in mice is associated with age-dependent susceptibility to vascular thrombosis.
- Enhanced phagocytosis through inhibition of de novo ceramide synthesis.
- Granulocyte colony-stimulating factor primes NADPH oxidase in neutrophils through translocation of cytochrome b(558) by gelatinase-granule release.
- Regulation of phospholipase C-gamma activity by glycosphingolipids.
- Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase.
- Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D.
- Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.
- The design and clinical development of inhibitors of glycosphingolipid synthesis: will invention be the mother of necessity?
- Glycosphingolipids modulate Renal phosphate transport in potassium deficiency.
- Vascular dysfunction in the alpha-galactosidase A-knockout mouse is an endothelial cell-, plasma membrane-based defect.
- Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-Glc:ceramide glucosyltransferase strongl...
- A role for lysosomal phospholipase A2 in drug induced phospholipidosis.
- Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher Disease using enzyme and substrate reduction therapy.
- Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone.
- Group XV phospholipase A₂, a lysosomal phospholipase A₂.
- The T lymphocyte structure CD60 contains a sialylated carbohydrate epitope that is expressed on both gangliosides and glycoproteins.
- Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle.
- Use of sulfobutyl ether beta-cyclodextrin as a vehicle for D-threo-1-phenyl-2-decanoylamino-3-morpholinopropanol-relat ed glucosylceramide synthase inhibitors.
- Sphingolipids.
- Reduction of globotriaosylceramide in Fabry Disease mice by substrate deprivation.
- Phosphorylation-dephosphorylation of retinoblastoma protein not necessary for passage through the mammalian cell division cycle.
- Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase.
- Glycosphingolipid depletion in fabry Disease lymphoblasts with potent inhibitors of glucosylceramide synthase.
- Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion.
- Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
- Inhibitors of glucosylceramide synthase.
- 1-O-acylceramide synthase.
- Glucosylceramide synthase: assay and properties.
- Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation.
- The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion.
- Activation of a plasma membrane-associated neutral sphingomyelinase and concomitant ceramide accumulation during IgG-dependent phagocytosis in human polymorphonuclear ...
- Effect of an inhibitor of glucosylceramide synthesis on cultured human keratinocytes.
- Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity.
- Establishing a role for sphingolipids in Renal injury and stress responses.
- Mitogen-activated protein kinase activation during IgG-dependent phagocytosis in human neutrophils: inhibition by ceramide.
- Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes.
- Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology.
- Sphingolipids: their role in intracellular signaling and Renal growth.
- Glycosphingolipid synthesis and proliferation in a Renal cell line grown in high glucose.
- A novel enzyme that catalyzes the esterification of N-acetylsphingosine. Metabolism of C2-ceramides.
- (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase.
- Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription.
- Induction of glucosylceramide synthase by synthase inhibitors and ceramide.
- Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells.
- A role for glycosphingolipid accumulation in the Renal hypertrophy of streptozotocin-induced diabetes mellitus.
- Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances.
- Dissociation of endogenous cellular ceramide from NF-kappa B activation.
- Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils.
- Role of diradylglycerol formation in H2O2 and lactoferrin release in adherent human polymorphonuclear leukocytes.
- Ceramide regulates oxidant release in adherent human neutrophils.
- Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases.
Schools
Washington University St Louis
Barnes Jewish Hospital
Washington University
Procedures Preformed
- Hemodialysis
Conditions Treated
- Chronic Kidney Diseases
- Congenital Cystic Kidney Disease
- Congenital Polycystic Kidney Disease
- End-Stage Renal Disease
- View All
Doctors Specialties
- Nephrology
Accepted Insurances
Awards
- Elected Member
- Fellow (ASNF)
Education
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Washington University - Barnes-Jewish Hospital -
Washington University School of Medicine in St. Louis
Hospital
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University of Michigan Hospitals and Health Centers
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