Professor, Obstetrics and Gynecology, Uniformed Services Hebert SOM
Obstetrics & Gynecology
Dr. James H. Segars Jr., MD
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James H. Segars Jr. is an expert in the field of Obstetrics & Gynecology. He went to Duke University School of Medicine. Duke University School of Medicine is a one of the best medicals schools. Duke University School of Medicine is ranked 8/29 in Research/PrimaryCare. He received 1 awards: "Fellow (FACOG)". Dr. James H. Segars Jr. is a published doctor and has 67 publications published. The lastest was: 'DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3'-end GC density.'
Publications
- Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review.
- GnRH agonist reduces estrogen receptor dimerization in GT1-7 cells: Evidence for cross-talk between membrane-initiated estrogen and GnRH signaling.
- DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3'-end GC density.
- Dynamic reciprocity between cells and their microenvironment in reproduction.
- Leiomyoma cells in 3-dimensional cultures demonstrate an attenuated response to fasudil, a rho-kinase inhibitor, when compared to 2-dimensional cultures.
- Uterine Fibroid Research: A Work in Progress.
- Mechanical Signaling in Reproductive Tissues: Mechanisms and Importance.
- Reproductive impact of MRI-guided focused ultrasound surgery for fibroids: a systematic review of the evidence.
- Cost-effectiveness analysis comparing continuation of assisted reproductive technology with conversion to intrauterine insemination in patients with low follicle numbers.
- Liarozole inhibits transforming growth factor-β3-mediated extracellular matrix formation in human three-dimensional leiomyoma cultures.
- Correcting reproductive health disparities in women: an opportunity to improve the health of future generations.
- Racial and ethnic health disparities in reproductive medicine: an evidence-based overview.
- Training in embryo transfer: how should it be done?
- The two health disparities of uterine fibroids.
- Serum human chorionic gonadotropin levels on the day before oocyte retrieval do not correlate with oocyte maturity.
- Integrin ò1 regulates leiomyoma cytoskeletal integrity and growth.
- Preconception stress and the secondary sex ratio: a prospective cohort study.
- The estimated annual cost of uterine leiomyomata in the United States.
- The prevalence of genuine empty follicle syndrome.
- Are there subtle genome-wide epigenetic alterations in normal offspring conceived by assisted reproductive technologies?
- Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma.
- Experience with a patient-friendly, mandatory, single-blastocyst transfer policy: the power of one.
- Environmental and epigenetic effects upon preimplantation embryo metabolism and development.
- Is anti-Müllerian hormone a marker of acute cyclophosphamide-induced ovarian follicular destruction in mice pretreated with cetrorelix?
- Subclinical elevations of thyroid-stimulating hormone and assisted reproductive technology outcomes.
- Proficiency in oocyte retrieval: how many procedures are necessary for training?
- The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction.
- The pathophysiology of ovarian hyperstimulation syndrome: an unrecognized compartment syndrome.
- The Guanine Nucleotide Exchange Factor Brx: A Link between Osmotic Stress, Inflammation and Organ Physiology and Pathophysiology.
- Is there a genetic basis for polycystic ovary syndrome?
- The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice.
- The mechanism responsible for the supraphysiologic gonadotropin surge in females treated with gonadotropin-releasing hormone (GnRH) agonist and primed with GnRH antago...
- Cost analysis model of outpatient management of ovarian hyperstimulation syndrome with paracentesis: "tap early and often" versus hospitalization.
- Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas.
- Epigenetics in reproduction.
- Imprinting disorders and assisted reproductive technology.
- Activating transcription factor 3 gene expression suggests that tissue stress plays a role in leiomyoma development.
- Assessment of ovarian function with anti-Müllerian hormone in systemic lupus erythematosus patients undergoing hematopoietic stem cell transplant.
- Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
- A new approach to ovarian reserve testing.
- Mechanical homeostasis is altered in uterine leiomyoma.
- The combined effect of age and basal follicle-stimulating hormone on the cost of a live birth at assisted reproductive technology.
- Compensatory alterations in energy homeostasis characterized in uterine tumors from hereditary leiomyomatosis and renal cell cancer.
- Invited comment: "Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats".
- The second National Institutes of Health International Congress on advances in uterine leiomyoma research: conference summary and future recommendations.
- A new hypothesis about the origin of uterine fibroids based on gene expression profiling with microarrays.
- The promise and perils of microarray analysis.
- Estrogen effects on the expression of Brx in the brain and pituitary of the mouse.
- Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system.
- Treatment with gonadotropin-releasing hormone (GnRH) antagonists in women suppressed with GnRH agonist may avoid cycle cancellation in patients at risk for ovarian hyp...
- Adhesion formation after laparoscopic excision of endometriosis and lysis of adhesions.
- Embryo afterloading: a refinement in embryo transfer technique that may increase clinical pregnancy.
- Anthrax vaccine does not affect semen parameters, embryo quality, or pregnancy outcome in couples with a vaccinated male military service member.
- A suboptimal endometrial pattern is associated with a reduced likelihood of pregnancy after a day 5 embryo transfer.
- Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium.
- Prognostic use of mean ovarian volume in in vitro fertilization cycles: a prospective assessment.
- Assessment of resident competency in the performance of sonohysterography: does the level of training impact the accuracy?
- Reduced dermatopontin expression is a molecular link between uterine leiomyomas and keloids.
- New potential regulators of uterine leiomyomata from DNA arrays: the ionotropic glutamate receptor GluR2.
- Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology.
- Microarray analysis in fibroids: which gene list is the correct list?
- A prospective assessment of the predictive value of basal antral follicles in in vitro fertilization cycles.
- Blastocyst transfer decreases multiple pregnancy rates in in vitro fertilization cycles: a randomized controlled trial.
- Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling.
- Estrogen action and cytoplasmic signaling cascades. Part I: membrane-associated signaling complexes.
- Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and...
Schools
Duke University
Doctors Specialties
- Obstetrics
- Gynecology
Accepted Insurances
Awards
- Fellow (FACOG)
Education
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Vanderbilt University -
University of Virginia -
Duke University School of Medicine
Hospital
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Johns Hopkins Hospital -
Johns Hopkins Bayview Medical Center
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