Professor, Pathology, University of Tennessee Health Science Center College of Medicine

Pathology

James R. Downing is an expert in the field of Pathology. He went to University of Michigan Medical School. He has 1 awards "Elected Member". Doctor James R. Downing, MD is a published MD. He has 38 publications published. The most current publication "Redefining "rare" in paediatric cancers." He is registered with Medicare and accepts Medicare payments.

Publications

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• Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.
• Redefining "rare" in paediatric cancers.
• Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels.
• Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms.
• Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.
• The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.
• Clinical utility of sequential minimal residual disease measurements in the context of risk-based therapy in childhood acute lymphoblastic leukaemia: a prospective study.
• Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations.
• The Genomic Landscape of Childhood and Adolescent Melanoma.
• Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy.
• Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.
• PTEN action in leukaemia dictated by the tissue microenvironment.
• A revised definition for cure of childhood acute lymphoblastic leukemia.
• Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.
• C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.
• LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways.
• RB1 gene inactivation by chromothripsis in human retinoblastoma.
• Targeting oxidative stress in embryonal rhabdomyosarcoma.
• A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia.
• RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients.
• Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.
• Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation.
• Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
• Lmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemia.
• Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.
• The genomic landscape of hypodiploid acute lymphoblastic leukemia.
• Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project.
• Comparative Analysis of Different Approaches to Measure Treatment Response in Acute Myeloid Leukemia.
• Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.
• Treatment Outcomes in Black and White Children With Cancer: Results From the SEER Database and St Jude Children's Research Hospital, 1992 Through 2007.
• Increased risk for CNS relapse in pre-B cell leukemia with the t(1;19)/TCF3-PBX1.
• Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: results of the St Jude AML97 trial.
• Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: recent insights and future directions.
• Acute mixed lineage leukemia in children: the experience of St Jude Children's Research Hospital.
• Genomic landscape of paediatric adrenocortical tumours.
• Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.
• The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.

Schools

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• University of Mi Med Sch

Doctors Specialties

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• Anatomic Pathology
• Pathology

Accepted Insurances

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Awards

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• Elected Member

Education

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• Barnes-Jewish Hospital
• Washington University - Barnes-Jewish Hospital
• University of Michigan Medical School

Hospital

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• University of Tennessee Medical Center

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