Professor, Internal Medicine, Ohio State University College of Medicine
Cardiology
Dr. Jay L. Zweier, MD
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Zweier is an expert in the field of Cardiology. He studied medicine at University of Maryland School of Medicine. University of Maryland School of Medicine has a rank of 37 in research and a 52 in primary care He received awards:"Elected Member" and "Fellow (FACC)". Zweier has written publications. He has 101 publications published with PubMed. The lastest publication is: 'Poly-arginine conjugated triarylmethyl radical as intracellular spin label.'
Publications
- Sulfite Oxidase Activity of Cytochrome c: Role of Hydrogen Peroxide.
- Poly-arginine conjugated triarylmethyl radical as intracellular spin label.
- Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling.
- Fluid Mechanical Forces and Endothelial Mitochondria: A Bioengineering Perspective.
- Endothelial nitric oxide synthase uncoupling: A novel pathway in OSA induced vascular endothelial dysfunction.
- Measurement and characterization of superoxide generation from xanthine dehydrogenase: a redox-regulated pathway of radical generation in ischemic tissues.
- Mitochondrial uncoupling does not decrease reactive oxygen species production after ischemia-reperfusion.
- Proton-Electron Double-Resonance Imaging of pH using phosphonated trityl probe.
- Hypoxia and Reoxygenation Induce Endothelial Nitric Oxide Synthase Uncoupling in Endothelial Cells through Tetrahydrobiopterin Depletion and S-Glutathionylation.
- Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation.
- Effect of temperature, pH and heme ligands on the reduction of Cygb(Fe(3+)) by ascorbate.
- Iron and noncontrast magnetic resonance T2* as a marker of intraplaque iron in human atherosclerosis.
- Fourier Transform EPR Spectroscopy of Trityl Radicals for Multifunctional Assessment of Chemical Microenvironment.
- Reoxygenation-derived toxic reactive oxygen/nitrogen species modulate the contribution of bone marrow progenitor cells to remodeling after myocardial infarction.
- Cardiac mitochondria and reactive oxygen species generation.
- In Vivo Proton-Electron Double-Resonance Imaging of Extracellular Tumor pH Using an Advanced Nitroxide Probe.
- Compressed sensing of spatial electron paramagnetic resonance imaging.
- Redox Modulation of Endothelial Nitric Oxide Synthase by Glutaredoxin-1 through Reversible Oxidative Post-Translational Modification.
- Differences In Oxygen-Dependent Nitric Oxide Metabolism By Cytoglobin And Myoglobin Account For Their Differing Functional Roles.
- Uniform spinning sampling gradient electron paramagnetic resonance imaging.
- Structural Factors Controlling the Spin-Spin Exchange Coupling: EPR Spectroscopic Studies of Highly Asymmetric Trityl-Nitroxide Biradicals.
- Fast gated EPR imaging of the beating heart: Spatiotemporally resolved 3D imaging of free-radical distribution during the cardiac cycle.
- Esterified Dendritic TAM Radicals with Very High Stability and Enhanced Oxygen Sensitivity.
- Tetrathiatriarylmethyl radical with a single aromatic hydrogen as a highly sensitive and specific superoxide probe.
- Myocardial Infarction in Sickle Cell Disease: Use of Translational Imaging to Diagnose an Under-Recognized Problem.
- Cardiomyocyte-specific Overexpression of an Active Form of Rac Predisposes the Heart to Increased Myocardial Stunning and Ischemia/Reperfusion Injury.
- Early Ischemic Preconditioning Requires Akt- and PKA-mediated Activation of eNOS via Serine1176 Phosphorylation.
- Characterization of the mechanism and magnitude of cytoglobin-mediated nitrite reduction and nitric oxide generation under anaerobic conditions.
- Characterization of the function of cytoglobin as an oxygen-dependent regulator of nitric oxide concentration.
- Ischemic preconditioning preserves mitochondrial membrane potential and limits reactive oxygen species production.
- Dual-scan acquisition for accelerated continuous-wave EPR oximetry.
- Aldehyde Oxidase Functions as a Superoxide Generating NADH Oxidase: An Important Redox Regulated Pathway of Cellular Oxygen Radical Formation.
- HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: Application to tetrahydrobiopterin auto...
- Electron paramagnetic resonance monitoring of ischemia-induced myocardial oxygen depletion and acidosis in isolated rat hearts using soluble paramagnetic probes.
- In vivo proton electron double resonance imaging of mice With fast spin echo pulse sequence.
- In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors.
- Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species.
- Cardiac resynchronization therapy and reverse molecular remodeling: importance of mitochondrial redox signaling.
- Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury.
- Celebrating Professor Britton Chance (1913-2010), a Founding Father of Redox Sciences.
- Suppression of eNOS-Derived Superoxide by Caveolin-1: A Biopterin-Dependent Mechanism.
- Standard-based method for proton-electron double resonance imaging of oxygen.
- Reply: Is NOS uncoupling the missing link between atrial fibrillation and chronic non-ischemic cardiomyopathy?
- Superoxide induces eNOS protein Thiyl radical formation: a novel mechanism regulating eNOS function and coupling.
- Vital Organ Tissue Oxygenation After Serial Normovolemic Exchange Transfusion with HBOC-201 in Anesthetized Swine.
- Synthesis of trityl radical-conjugated disulfide biradicals for measurement of thiol concentration.
- S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling.
- Removal of H(2)O(2) and generation of superoxide radical: Role of cytochrome c and NADH.
- Variable radio frequency proton-electron double-resonance imaging: application to pH mapping of aqueous samples.
- Targeting dimethylarginine dimethylaminohydrolases in pulmonary arterial hypertension: a new approach to improve vascular dysfunction?
- Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation c...
- Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway.
- Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion.
- Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice.
- Ischemic preconditioning decreases mitochondrial proton leak and reactive oxygen species production in the postischemic heart.
- Application of carbon fiber composite minielectrodes for measurement of kinetic constants of nitric oxide decay in solution.
- Ischemic postconditioning does not provide cardioprotection from long-term ischemic injury in isolated male or female rat hearts.
- Fast Reactivity of a Cyclic Nitrone-Calix[4]pyrrole Conjugate with Superoxide Radical Anion: Theoretical and Experimental Studies (†).
- Synthesis of (14)N- and (15)N-labeled Trityl-nitroxide Biradicals with Strong Spin-Spin Interaction and Improved Sensitivity to Redox Status and Oxygen.
- eNOS is required for acute in vivo ischemic preconditioning of the heart: effects of ischemic duration and sex.
- A novel variable field system for field-cycled dynamic nuclear polarization spectroscopy.
- Dual frequency resonator for 1.2 GHz EPR/16.2 MHz NMR co-imaging.
- Role of heat shock factor-1 activation in the doxorubicin-induced heart failure in mice.
- Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition.
- Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall.
- Oxygen regulates the effective diffusion distance of nitric oxide in the aortic wall.
- Reactive oxygen and nitrogen species regulate inducible nitric oxide synthase function shifting the balance of nitric oxide and superoxide production.
- Variable Field Proton-Electron Double-Resonance Imaging: Application to pH mapping of aqueous samples.
- Peptide-based antibodies against glutathione-binding domains suppress superoxide production mediated by mitochondrial complex I.
- Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite.
- Nitrate and nitrite in biology, nutrition and therapeutics.
- Direct chemiluminescence detection of nitric oxide in aqueous solutions using the natural nitric oxide target soluble guanylyl cyclase.
- Ox-LDL modifies the behavior of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation.
- MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2.
- Trityl-based EPR probe with enhanced sensitivity to oxygen.
- Lipophilic beta-cyclodextrin cyclic-nitrone conjugate: synthesis and spin trapping studies.
- Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.
- Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase.
- Segmented surface coil resonator for in vivo EPR applications at 1.1GHz.
- The radical trap 5,5-dimethyl-1-pyrroline N-oxide exerts dose-dependent protection against myocardial ischemia-reperfusion injury through preservation of mitochondrial...
- Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.
- Esterified trityl radicals as intracellular oxygen probes.
- Superoxide radical anion adduct of 5,5-dimethyl-1-pyrroline N-oxide. 4. Conformational effects on the EPR hyperfine splitting constants.
- Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase.
- Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition.
- Formation of hydrogen peroxide and reduction of peroxynitrite via dismutation of superoxide at reperfusion enhances myocardial blood flow and oxygen consumption in pos...
- Activation of Hsp90-eNOS and increased NO generation attenuate respiration of hypoxia-treated endothelial cells.
- Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium.
- Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme.
- Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK.
- Synthesis and characterization of amino derivatives of persistent trityl radicals as dual function pH and oxygen paramagnetic probes.
- Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall.
- Regulation of eNOS-derived superoxide by endogenous methylarginines.
- Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite.
- Biphasic effect of SIN-1 is reliant upon cardiomyocyte contractile state.
- Nitric oxide production from nitrite occurs primarily in tissues not in the blood: critical role of xanthine oxidase and aldehyde oxidase.
- Characterization of the structural and functional changes in the myocardium following focal ischemia-reperfusion injury.
- Synthesis and spin-trapping properties of a new spirolactonyl nitrone.
- HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest.
- Dose dependent effects of reactive oxygen and nitrogen species on the function of neuronal nitric oxide synthase.
Schools
University of Maryland At Baltimore Professional Schools
Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Elected Member
- Fellow (FACC)
Education
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Johns Hopkins University -
Sinai Hospital of Baltimore -
University of Maryland -
University of Maryland School of Medicine
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