Professor, Internal Medicine, Washington University School of Medicine
Cardiology
Dr. Jean E. Schaffer, MD
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Jean Schaffer works in the field of Cardiology. She attended Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School has a rank of 1 in research and a 12 in primary care She has 1 awards "Elected Member". Jean Schaffer is also a published doctor. She has 69 paper published. The most recent paper is: Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transport. She accepts all Medicare patients.
Publications
- A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study.
- RNASET2 is required for ROS propagation during oxidative stress-mediated cell death.
- A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol.
- Cytosolic Accumulation of Small Nucleolar RNAs (snoRNAs) is Dynamically Regulated by NADPH Oxidase.
- Plasma Sphingolipids Associated with COPD Phenotypes.
- Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative Disease Niemann-Pick C1 (NPC1).
- Box C/D snoRNA U60 Regulates Intracellular Cholesterol Trafficking.
- Development and validation of LC-MS/MS method for determination of very long acyl chain (C22:0 and C24:0) ceramides in human plasma.
- Identification of Niemann-Pick C1 (NPC1) Disease biomarkers through sphingolipid profiling.
- TLR4 Activation Under Lipotoxic Conditions Leads to Synergistic Macrophage Cell Death through a TRIF-Dependent Pathway.
- Endothelial Acyl-CoA Synthetase 1 Is Not Required for Inflammatory and Apoptotic Effects of a Saturated Fatty Acid-Rich Environment.
- Metabolic stress in the myocardium: Adaptations of gene expression.
- Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress.
- A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 Disease from human plasma.
- Cholesterol oxidation products are sensitive and specific blood-based biomarkers for Niemann-Pick C1 Disease.
- ApoA-1 in diabetes: damaged goods.
- Diet-induced obesity model: abnormal oocytes and persistent growth abnormalities in the offspring.
- DGAT1 expression increases Heart triglyceride content but ameliorates lipotoxicity.
- As a matter of fat.
- The non-coding RNA gadd7 is a regulator of lipid-induced oxidative and endoplasmic reticulum stress.
- Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions.
- Ca2+-independent alterations in diastolic sarcomere length and relaxation kinetics in a mouse model of lipotoxic diabetic Cardiomyopathy.
- Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.
- Niemann-Pick type C1 I1061T mutant encodes a functional protein that is selected for endoplasmic reticulum-associated degradation due to protein misfolding.
- Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death.
- Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C Disease.
- Alpha-lipoic acid prevents lipotoxic Cardiomyopathy in acyl CoA-synthase transgenic mice.
- A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.
- Fatty acid transport protein 1 and long-chain acyl coenzyme A synthetase 1 interact in adipocytes.
- A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death.
- Measurements of the cyclic variation of myocardial backscatter from two-dimensional echocardiographic images as an approach for characterizing diabetic Cardiomyopathy.
- Lipotoxicity in the Heart.
- The sterol-sensing domain of the Niemann-Pick C1 (NPC1) protein regulates trafficking of low density lipoprotein cholesterol.
- Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic Cardiomyopathy.
- Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.
- Hyperleptinemia prevents lipotoxic Cardiomyopathy in acyl CoA synthase transgenic mice.
- cAMP Dose-dependently prevents palmitate-induced apoptosis by both protein kinase A- and cAMP-guanine nucleotide exchange factor-dependent pathways in beta-cells.
- The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking.
- NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.
- Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development.
- Oligomerization of the murine fatty acid transport protein 1.
- Triglyceride accumulation protects against fatty acid-induced lipotoxicity.
- FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation.
- Mechanisms of lipoapoptosis: implications for human heart Disease.
- Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system.
- Fatty acid transport: the roads taken.
- No evidence of KSHV/HHV-8 in mycosis fungoides or associated disorders.
- Urinary incontinence and pelvic organ prolapse in women with Marfan or Ehlers Danlos Syndrome.
- Incidence, risk factors and morbidity of unintended bladder or ureter injury during hysterectomy.
- Urogenital effects of the menopause.
- Molecular mechanism of long-chain fatty acid uptake.
- Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein.
- A novel adipocyte long chain fatty acid transport protein.
- Limits of a localized magnetic resonance spectroscopy assay for ex vivo Myocardial triacylglycerol.
- Molecular aspects of fatty acid transport: mutations in the IYTSGTTGXPK motif impair fatty acid transport protein function.
- Regulation of the murine adipocyte fatty acid transporter gene by insulin.
- Substitution of alanine for serine 250 in the murine fatty acid transport protein inhibits long chain fatty acid transport.
- Characterization of the murine fatty acid transport protein gene and its insulin response sequence.
- Localization of adipocyte long-chain fatty acyl-CoA synthetase at the plasma membrane.
- Cholesterol overload promotes morphogenesis of a Niemann-Pick C (NPC)-like compartment independent of inhibition of NPC1 or HE1/NPC2 function.
- Membrane topology of the murine fatty acid transport protein 1.
- A novel mouse model of lipotoxic Cardiomyopathy.
- Palmitate-induced apoptosis can occur through a ceramide-independent pathway.
- Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis.
- Lipotoxicity: when tissues overeat.
- Quantitative analysis of the magnitude and time delay of cyclic variation of Myocardial backscatter from asymptomatic type 2 diabetes mellitus subjects.
- Echocardiographic tissue characterization demonstrates differences in the left and right sides of the ventricular septum.
- Bayesian parameter estimation for characterizing the cyclic variation of echocardiographic backscatter to assess the Hearts of asymptomatic type 2 diabetes mellitus su...
Schools
Harvard Medical School
Beth Israel Deaconess Hp M C
Brigham and Women39s Hospital
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomegaly
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Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Elected Member
Education
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Beth Israel Deaconess Medical Center -
Brigham and Women's Hospital -
Harvard Medical School
Hospital
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Barnes-Jewish Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1265450712 |
| Last Name Of The Provider | SCHAFFER |
| First Name Of The Provider | JEAN |
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