Senior Investigator, National Cancer Institute
Pediatric Hematology & Oncology
Dr. Jeffrey A. Moscow, MD
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Jeffrey A. Moscow, MD is an expert in the field of Pediatric Hematology & Oncology. He graduated from Geisel School of Medicine at Dartmouth. Geisel School of Medicine at Dartmouth is ranked 37/29 in Research/PrimaryCare. Jeffrey Moscow is a published physician as well. He has 64 publications published. The latest was: Methotrexate transport and resistance.
Publications
- Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.
- Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy.
- Metabolic effects of Acute thiamine depletion are reversed by rapamycin in breast and leukemia cells.
- The Effect of BCRP, MDR1 and OATP1B3 on the Antitumor Efficacy of the Lipophilic Camptothecin AR-67 In Vitro.
- Low-Thiamine Diet Increases Mammary Tumor Latency in FVB/N-Tg(MMTVneu) Mice.
- Pharmacologic properties of polyethylene glycol-modified Bacillus thiaminolyticus thiaminase I enzyme.
- Linear chain PEGylated recombinant Bacillus thiaminolyticus thiaminase I enzyme has growth inhibitory activity against lymphoid Leukemia cell lines.
- 2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: Implications for the reactive oxygen species-mediated...
- Configuration and rearrangement of the human GAGE gene clusters.
- Can an enzyme cofactor be a factor in malignant progression?
- A phase I study of 7-t-butyldimethylsilyl-10-hydroxycamptothecin in adult patients with refractory or metastatic solid malignancies.
- Chemo Brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction.
- Human rRNA gene clusters are recombinational hotspots in Cancer.
- Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa Cells.
- Transfusion management strategies: a survey of practicing pediatric hematology/oncology specialists.
- A survey of clinical productivity and current procedural terminology (CPT) coding patterns of pediatric hematologist/oncologists.
- Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaGlandin metabolism in breast cancer cells.
- Down-regulation of thiamine transporter THTR2 gene expression in breast Cancer and its association with resistance to apoptosis.
- Basolateral active uptake of nitrofurantoin in the CIT3 Cell culture model of lactation.
- Specific association of thiamine-coated gadolinium nanoparticles with human breast Cancer cells expressing thiamine transporters.
- Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy.
- The murine-reduced folate carrier gene can act as a selectable marker and a suicide gene in hematopoietic Cells in vivo.
- Correlation of nucleoside and nucleobase transporter gene expression with antimetabolite drug cytotoxicity.
- Selectivity and Potency of Microcystin Congeners against OATP1B1 and OATP1B3 Expressing Cancer Cells.
- Interstitial nephritis, hepatic failure, and Systemic eosinophilia after minocycline treatment.
- Down-regulation of reduced folate carrier gene (RFC1) expression after exposure to methotrexate in ZR-75-1 breast Cancer cells.
- Interactions between cimetidine, nitrofurantoin, and probenecid active transport into rat milk.
- Langerhans cell histiocytosis after therapy for a malignant germ cell tumor of the central Nervous system.
- Paclitaxel chemotherapy after autologous stem-Cell transplantation and engraftment of hematopoietic Cells transduced with a retrovirus containing the multidrug resista...
- Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast Cancer chemotherapy.
- Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1).
- Methotrexate transport and resistance.
- Concentrating capacity of the human reduced folate carrier (hRFC1) in human ZR-75 breast Cancer cell lines.
- Multidrug resistance.
- Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected Cell lines.
- Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human Leukemia cell line.
- A pilot study of pi-class glutathione S-transferase expression in breast Cancer: correlation with estrogen receptor expression and prognosis in node-negative breast ca...
- Decreased melphalan accumulation in a human breast Cancer cell line selected for resistance to melphalan.
- Examination of human tumors for rhoA mutations.
- Glutathione transferase GST pi in breast tumors evaluated by three techniques.
- Utilization of multiple polyadenylation signals in the human RHOA protooncogene.
- Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung Cancer.
- Expression of the GST pi gene and response to tamoxifen therapy in locally advanced breast carcinomas.
- Glutathione-related enzymes, glutathione and multidrug resistance.
- Characterization of cross-resistance to methotrexate in a human breast Cancer cell line selected for resistance to melphalan.
- Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast Cancer ce...
- Positive direct antiglobulin test results after intravenous Immune globulin administration.
- Altered phenytoin clearance during intensive chemotherapy for Acute lymphoblastic leukemia.
- Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast Cancer.
- Elevation of pi class glutathione S-transferase activity in human breast Cancer cells by transfection of the GST pi gene and its effect on sensitivity to toxins.
- Glutathione S-transferase and drug resistance.
- Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human Tissues and tumors.
- Multidrug resistance in Cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-pi.
- Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma Cell lines.
- Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).
- Reduced folate carrier and dihydrofolate reductase expression in Acute lymphocytic leukemia may predict outcome: a Children''s Cancer Group Study.
- Transporter gene expression in lactating and nonlactating human mammary epithelial Cells using real-time reverse transcription-polymerase chain reaction.
- Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and Leukemias.
- NAD+-linked 15-hydroxyprostaGlandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
- Sensitivity of breast Cancer cell lines to recombinant thiaminase I.
- Spontaneous resolution of a single lesion of myeloid Leukemia cutis in an infant: case report and discussion.
- Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition.
- Addressing the design of in vitro models for the investigation of microcystins: the essential role of transporter-mediated uptake.
Schools
Dartmouth College
Conditions Treated
- Acute Leukemia
- Adrenal Gland Cancer
- Anemia
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
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Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Education
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National Institutes of Health Clinical Center -
Geisel School of Medicine at Dartmouth
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