Professor Emeritus, Hematology and Oncology, Baylor College of Medicine
Hematology
Dr. Joe L. Moake, MD
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Moake practices Hematology. He went to Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical college. Johns Hopkins University School of Medicine is ranked 3/29 in Research/PrimaryCare. Moake is a published doctor. He published 99 publications, including: 'Moschcowitz, multimers, and metalloprotease.'
Publications
- Platelet response to shear stress: changes in serotonin uptake, serotonin release, and ADP induced aggregation.
- Isolation from commercial aurintricarboxylic acid of the most effective polymeric inhibitors of von Willebrand factor interaction with platelet glycoprotein Ib. Compar...
- Effects of PGI2 and di-butyryl cyclic-AMP on platelets exposed to shear stress.
- Solvent/detergent-treated plasma suppresses shear-induced platelet aggregation and prevents episodes of thrombotic thrombocytopenic purpura.
- Aurintricarboxylic acid in a canine model of coronary artery thrombosis.
- Hairy cell leukemia in association with thrombotic thrombocytopenic purpura and factor VIII antibodies.
- ADAMTS-13 activity in plasma is rapidly measured by a new ELISA method that uses recombinant VWF-A2 domain as substrate.
- The incidence and significance of hemostatic abnormalities in patients with head injuries.
- Human endothelial cells synthesize and release ADAMTS-13.
- Attack of the acronyms: TTP, VWF, ADAMTS-13 and SELDI-TOF-MS.
- Conformational stability and domain unfolding of the Von Willebrand factor A domains.
- Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.
- ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals.
- Platelets in bloom.
- Thrombotic microangiopathies: multimers, metalloprotease, and beyond.
- Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies.
- Generation and breakdown of soluble ultralarge von Willebrand factor multimers.
- In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology.
- Measurement of von Willebrand factor cleaving protease (ADAMTS-13): results of an international collaborative study involving 11 methods testing the same set of coded ...
- Defective processing of unusually large von Willebrand factor multimers and thrombotic thrombocytopenic purpura.
- Shear stress-induced binding of large and unusually large von Willebrand factor to human platelet glycoprotein Ibalpha.
- N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice.
- Disulfide bond reduction of von Willebrand factor by ADAMTS-13.
- Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage.
- Protein phosphatase 2B inhibition promotes the secretion of von Willebrand factor from endothelial cells.
- Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (198...
- Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions.
- Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group.
- Journey in reverse: TTP from bedside to blood bank to bench.
- Thrombotic thrombocytopenic purpura: survival by "giving a dam".
- Enhanced platelet adhesion and aggregation by endothelial cell-derived unusually large multimers of von Willebrand factor.
- Novel ADAMTS-13 mutations in an adult with delayed onset thrombotic thrombocytopenic purpura.
- Platelet-derived VWF-cleaving metalloprotease ADAMTS-13.
- Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.
- Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers.
- Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress.
- Recent advances in thrombotic thrombocytopenic purpura.
- Severe hemolysis and red cell fragmentation caused by the combination of a spectrin mutation with a thrombotic microangiopathy.
- Cryosupernatant regulates accumulation of unusually large vWF multimers from endothelial cells.
- Abnormalities of von Willebrand factor multimers in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
- Hypercoagulable states.
- Effectiveness of the cryosupernatant fraction of plasma in the treatment of refractory thrombotic thrombocytopenic purpura.
- von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura.
- P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface.
- A novel flow cytometric analysis for platelet activation on immobilized von Willebrand factor or fibrillar collagen.
- ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.
- Case series of thrombotic thrombocytopenic purpura in children and adolescents.
- Characterization of von Willebrand factor interaction with collagens in real time using surface plasmon resonance.
- Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome.
- ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.
- In vitro comparison of blood pump induced platelet microaggregates between a centrifugal and roller pump during cardiopulmonary bypass.
- Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers.
- Measurement of the binding forces between von Willebrand factor and variants of platelet glycoprotein Ibalpha using optical tweezers.
- Thrombotic thrombocytopenic purpura: the systemic clumping "plague".
- Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow.
- Direct detection of red blood cell fragments: a new flow cytometric method to evaluate hemolysis in blood pumps.
- Report on the workshop: Von Willebrand factor and Thrombotic Thrombocytopenic Purpura.
- Bilateral combined occlusion of the central retinal artery and vein secondary to thrombotic thrombocytopenic purpura.
- Thrombotic thrombocytopenic purpura associated with clopidogrel.
- Antibody inhibitors to von Willebrand factor metalloproteinase and increased binding of von Willebrand factor to platelets in ticlopidine-associated thrombotic thrombo...
- Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
- Thrombotic thrombocytopenic purpura today.
- von Willebrand factor in the pathophysiology of thrombotic thrombocytopenic purpura.
- Moschcowitz, multimers, and metalloprotease.
- Increased von Willebrand factor (vWf) binding to platelets associated with impaired vWf breakdown in thrombotic thrombocytopenic purpura.
- Thrombotic thrombocytopenic purpura: understanding a disease no longer rare.
- Increased von Willebrand factor binding to platelets in single episode and recurrent types of thrombotic thrombocytopenic purpura.
- Fibrillin containing elastic microfibrils support platelet adhesion under dynamic shear conditions.
- Shear stress-induced binding of von Willebrand factor to platelets.
- Studies on the pathophysiology of thrombotic thrombocytopenic purpura.
- Effects of Integrelin on platelet function in flow models of arterial thrombosis.
- Familial infantile thrombotic thrombocytopenic purpura.
- Platelets and shear stress.
- Thrombotic microangiopathies associated with drugs and bone marrow transplantation.
- Direct demonstration of radiolabeled von Willebrand factor binding to platelet glycoprotein Ib and IIb-IIIa in the presence of shear stress.
- Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets.
- Unusually large von Willebrand factor multimers preferentially promote young sickle and nonsickle erythrocyte adhesion to endothelial cells.
- Abnormalities of von Willebrand factor multimers in drug-associated thrombotic microangiopathies.
- von Willebrand factor multimeric levels and patterns in patients with severe preeclampsia.
- Platelet function, surface structure and antigenicity.
- The role of von Willebrand factor (vWF) in thrombotic thrombocytopenic purpura (TTP) and the hemolytic-uremic syndrome (HUS).
- von Willebrand factor in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
- Recent observations on the pathophysiology of thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
- Granulocyte proteases do not process endothelial cell-derived unusually large von Willebrand factor multimers to plasma vWF in vivo.
- TTP--desperation, empiricism, progress.
- Acute renal failure in a female adolescent with leukemia in remission.
- von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.
- Haemolytic-uraemic syndrome: basic science.
- Comparative real-time effects on platelet adhesion and aggregation under flowing conditions of in vivo aspirin, heparin, and monoclonal antibody fragment against glyco...
- Postpartum thrombotic thrombocytopenic purpura complicated by Budd-Chiari syndrome.
- Platelet adhesion and aggregation on human type VI collagen surfaces under physiological flow conditions.
- Fibrinolysis inhibits shear stress-induced platelet aggregation.
- Delayed and recurrent intracranial hematomas related to disseminated intravascular clotting and fibrinolysis in head injury.
- Prothrombin Houston: a dysprothrombin identifiable by crossed immunoelectrofocusing and abnormal Echis carinatus venom activation.
- Metabolic requirements of contractile force generation in platelet rich plasma - a rheological study.
- Bernard-Soulier disease: a study of four patients and their parents.
- Effects of antiplatelet agents on platelets exposed to shear stress.
- Effects of colchicine and vinblastine on platelet contractility and release.
Schools
Johns Hopkins University School of Medicine
Doctors Specialties
- Hematology
Accepted Insurances
Education
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Jackson Memorial Hospital - Jackson Health System -
University of Florida -
Johns Hopkins University School of Medicine
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